Time-course changes in 5-fluorouracil-induced neural progenitor cell damages in the developing rat brain

5-Fluorouracil (5-Fu) is a DNA-damaging agent and teratogenic in rodents. This study aimed to investigate its influence on neural progenitor cells (NPCs) in the developing fetal rat brain. Dams were intraperitoneally injected with 5-Fu (50 mg/kg b.w.) on gestation day 13 and its effects on fetal NPC...

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Veröffentlicht in:	Journal of Toxicologic Pathology 2021, Vol.34(4), pp.299-308
Hauptverfasser:	Yamaguchi, Yuko, Fukunaga, Yachiyo, Takagi, Mizuho, Saito, Tsubasa, Tamura, Kazutoshi, Hoshiya, Toru
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Apoptosis Brain damage Caspase-3 Cell cycle Cells (biology) DNA damage Fetuses histopathology immunohistochemistry neural progenitor cell damage Neural stem cells Original Progenitor cells Telencephalon Teratogenicity time-course change Ventricle Ventricular zone
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