Diagnostic value of [18F]FDG-PET/CT for treatment monitoring in large vessel vasculitis: a systematic review and meta-analysis
Purpose Monitoring disease activity in patients with large vessel vasculitis (LVV) can be challenging. [18F]FDG-PET/CT is increasingly used to evaluate treatment response in LVV. In this systematic review and meta-analysis, we aimed to summarize the current evidence on the value of [18F]FDG-PET/CT f...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2021-11, Vol.48 (12), p.3886-3902 |
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| creator | van der Geest, K. S. M. Treglia, G. Glaudemans, A. W. J. M. Brouwer, E. Sandovici, M. Jamar, F. Gheysens, O. Slart, R. H. J. A. |
| description | Purpose
Monitoring disease activity in patients with large vessel vasculitis (LVV) can be challenging. [18F]FDG-PET/CT is increasingly used to evaluate treatment response in LVV. In this systematic review and meta-analysis, we aimed to summarize the current evidence on the value of [18F]FDG-PET/CT for treatment monitoring in LVV.
Methods
PubMed/MEDLINE and the Cochrane library database were searched from inception through October 21, 2020. Studies containing patients with LVV (i.e. giant cell arteritis, Takayasu arteritis and isolated aortitis) that received treatment and underwent [18F]FDG-PET/CT were included. Screening, full-text review and data extraction were performed by 2 investigators. The risk of bias was examined with the QUADAS-2 tool. Meta-analysis of proportions and diagnostic test accuracy was performed by a random-effects model and bivariate model, respectively.
Results
Twenty-one studies were included in the systematic review, of which 8 studies were eligible for meta-analysis. Arterial [18F]FDG uptake decreased upon clinical remission in longitudinal studies. High heterogeneity (
I
2
statistic 94%) precluded meta-analysis of the proportion of patients in which the scan normalized during clinical remission. Meta-analysis of cross-sectional studies indicated that [18F]FDG-PET/CT may detect relapsing/refractory disease with a sensitivity of 77% (95%CI 57–90%) and specificity of 71% (95%CI 47–87%). Substantial heterogeneity was observed among the cross-sectional studies. Both variation in clinical aspects and imaging procedures contributed to the heterogeneity.
Conclusion
Treatment of LVV leads to reduction of arterial [18F]FDG uptake during clinical remission. [18F]FDG-PET/CT has moderate diagnostic accuracy for detecting active LVV. [18F]FDG-PET/CT may aid treatment monitoring in LVV, but its findings should be interpreted in the context of the clinical suspicion of disease activity. This study underlines the relevance of published procedural recommendations for the use of [18F]FDG-PET/CT in LVV. |
| doi_str_mv | 10.1007/s00259-021-05362-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8484162</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2577917135</sourcerecordid><originalsourceid>FETCH-LOGICAL-c491t-3797b9e0e0fe862be35c365f5856368aec6013e410761f68b307efb3b122b4f3</originalsourceid><addsrcrecordid>eNp9kU1v1DAQhiMEoqXwBzggS1y4hHrsxHY4IFXbbkGqBIe9IWQ56WRxlcSLx1m0F347XrYsHwdOtuRnXs-rpyieA38NnOtz4lzUTckFlLyWSpTmQXEKCppSc9M8PN41PymeEN1xDkaY5nFxImVTCajgtPh-6d16CpR8x7ZumJGFnn0Cs_y8vLwuP16tzhcr1ofIUkSXRpwSG8PkU4h-WjM_scHFNbItEuGQE6ibB588vWGO0Y4Sjm4fHXHr8Rtz0y0bMbnSTW7YkaenxaPeDYTP7s-zYrW8Wi3elTcfrt8vLm7KrmoglVI3um2QI-_RKNGirDup6r42tZLKOOwUB4kVcK2gV6aVXGPfyhaEaKtenhVvD7GbuR3xtss1ohvsJvrRxZ0Nztu_Xyb_xa7D1prKVKBEDnh1HxDD1xkp2dFTh8PgJgwzWVELAQ3oSmb05T_oXZhj7runtM4QyDpT4kB1MRBF7I_LALd7u_Zg12a79qdda_LQiz9rHEd-6cyAPAC02fvB-Pvv_8T-AJw6sNQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2577917135</pqid></control><display><type>article</type><title>Diagnostic value of [18F]FDG-PET/CT for treatment monitoring in large vessel vasculitis: a systematic review and meta-analysis</title><source>MEDLINE</source><source>SpringerLink_现刊</source><creator>van der Geest, K. S. M. ; Treglia, G. ; Glaudemans, A. W. J. M. ; Brouwer, E. ; Sandovici, M. ; Jamar, F. ; Gheysens, O. ; Slart, R. H. J. A.</creator><creatorcontrib>van der Geest, K. S. M. ; Treglia, G. ; Glaudemans, A. W. J. M. ; Brouwer, E. ; Sandovici, M. ; Jamar, F. ; Gheysens, O. ; Slart, R. H. J. A.</creatorcontrib><description>Purpose
Monitoring disease activity in patients with large vessel vasculitis (LVV) can be challenging. [18F]FDG-PET/CT is increasingly used to evaluate treatment response in LVV. In this systematic review and meta-analysis, we aimed to summarize the current evidence on the value of [18F]FDG-PET/CT for treatment monitoring in LVV.
Methods
PubMed/MEDLINE and the Cochrane library database were searched from inception through October 21, 2020. Studies containing patients with LVV (i.e. giant cell arteritis, Takayasu arteritis and isolated aortitis) that received treatment and underwent [18F]FDG-PET/CT were included. Screening, full-text review and data extraction were performed by 2 investigators. The risk of bias was examined with the QUADAS-2 tool. Meta-analysis of proportions and diagnostic test accuracy was performed by a random-effects model and bivariate model, respectively.
Results
Twenty-one studies were included in the systematic review, of which 8 studies were eligible for meta-analysis. Arterial [18F]FDG uptake decreased upon clinical remission in longitudinal studies. High heterogeneity (
I
2
statistic 94%) precluded meta-analysis of the proportion of patients in which the scan normalized during clinical remission. Meta-analysis of cross-sectional studies indicated that [18F]FDG-PET/CT may detect relapsing/refractory disease with a sensitivity of 77% (95%CI 57–90%) and specificity of 71% (95%CI 47–87%). Substantial heterogeneity was observed among the cross-sectional studies. Both variation in clinical aspects and imaging procedures contributed to the heterogeneity.
Conclusion
Treatment of LVV leads to reduction of arterial [18F]FDG uptake during clinical remission. [18F]FDG-PET/CT has moderate diagnostic accuracy for detecting active LVV. [18F]FDG-PET/CT may aid treatment monitoring in LVV, but its findings should be interpreted in the context of the clinical suspicion of disease activity. This study underlines the relevance of published procedural recommendations for the use of [18F]FDG-PET/CT in LVV.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-021-05362-8</identifier><identifier>PMID: 33942141</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Arteritis ; Bivariate analysis ; Cardiology ; Clinical aspects ; Computed tomography ; Cross-Sectional Studies ; Fluorine isotopes ; Fluorodeoxyglucose F18 ; Health services ; Heterogeneity ; Humans ; Imaging ; Infection and inflammation ; Medical diagnosis ; Medicine ; Medicine & Public Health ; Meta-analysis ; Monitoring ; Nuclear Medicine ; Oncology ; Orthopedics ; Patients ; Positron emission ; Positron emission tomography ; Positron Emission Tomography Computed Tomography ; Radiology ; Radiopharmaceuticals ; Remission ; Remission (Medicine) ; Review ; Review Article ; Systematic review ; Takayasu's disease ; Telemedicine ; Tomography ; Vasculitis ; Vein & artery diseases</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2021-11, Vol.48 (12), p.3886-3902</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c491t-3797b9e0e0fe862be35c365f5856368aec6013e410761f68b307efb3b122b4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00259-021-05362-8$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00259-021-05362-8$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33942141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van der Geest, K. S. M.</creatorcontrib><creatorcontrib>Treglia, G.</creatorcontrib><creatorcontrib>Glaudemans, A. W. J. M.</creatorcontrib><creatorcontrib>Brouwer, E.</creatorcontrib><creatorcontrib>Sandovici, M.</creatorcontrib><creatorcontrib>Jamar, F.</creatorcontrib><creatorcontrib>Gheysens, O.</creatorcontrib><creatorcontrib>Slart, R. H. J. A.</creatorcontrib><title>Diagnostic value of [18F]FDG-PET/CT for treatment monitoring in large vessel vasculitis: a systematic review and meta-analysis</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Purpose
Monitoring disease activity in patients with large vessel vasculitis (LVV) can be challenging. [18F]FDG-PET/CT is increasingly used to evaluate treatment response in LVV. In this systematic review and meta-analysis, we aimed to summarize the current evidence on the value of [18F]FDG-PET/CT for treatment monitoring in LVV.
Methods
PubMed/MEDLINE and the Cochrane library database were searched from inception through October 21, 2020. Studies containing patients with LVV (i.e. giant cell arteritis, Takayasu arteritis and isolated aortitis) that received treatment and underwent [18F]FDG-PET/CT were included. Screening, full-text review and data extraction were performed by 2 investigators. The risk of bias was examined with the QUADAS-2 tool. Meta-analysis of proportions and diagnostic test accuracy was performed by a random-effects model and bivariate model, respectively.
Results
Twenty-one studies were included in the systematic review, of which 8 studies were eligible for meta-analysis. Arterial [18F]FDG uptake decreased upon clinical remission in longitudinal studies. High heterogeneity (
I
2
statistic 94%) precluded meta-analysis of the proportion of patients in which the scan normalized during clinical remission. Meta-analysis of cross-sectional studies indicated that [18F]FDG-PET/CT may detect relapsing/refractory disease with a sensitivity of 77% (95%CI 57–90%) and specificity of 71% (95%CI 47–87%). Substantial heterogeneity was observed among the cross-sectional studies. Both variation in clinical aspects and imaging procedures contributed to the heterogeneity.
Conclusion
Treatment of LVV leads to reduction of arterial [18F]FDG uptake during clinical remission. [18F]FDG-PET/CT has moderate diagnostic accuracy for detecting active LVV. [18F]FDG-PET/CT may aid treatment monitoring in LVV, but its findings should be interpreted in the context of the clinical suspicion of disease activity. This study underlines the relevance of published procedural recommendations for the use of [18F]FDG-PET/CT in LVV.</description><subject>Arteritis</subject><subject>Bivariate analysis</subject><subject>Cardiology</subject><subject>Clinical aspects</subject><subject>Computed tomography</subject><subject>Cross-Sectional Studies</subject><subject>Fluorine isotopes</subject><subject>Fluorodeoxyglucose F18</subject><subject>Health services</subject><subject>Heterogeneity</subject><subject>Humans</subject><subject>Imaging</subject><subject>Infection and inflammation</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Monitoring</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Orthopedics</subject><subject>Patients</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Positron Emission Tomography Computed Tomography</subject><subject>Radiology</subject><subject>Radiopharmaceuticals</subject><subject>Remission</subject><subject>Remission (Medicine)</subject><subject>Review</subject><subject>Review Article</subject><subject>Systematic review</subject><subject>Takayasu's disease</subject><subject>Telemedicine</subject><subject>Tomography</subject><subject>Vasculitis</subject><subject>Vein & artery diseases</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1v1DAQhiMEoqXwBzggS1y4hHrsxHY4IFXbbkGqBIe9IWQ56WRxlcSLx1m0F347XrYsHwdOtuRnXs-rpyieA38NnOtz4lzUTckFlLyWSpTmQXEKCppSc9M8PN41PymeEN1xDkaY5nFxImVTCajgtPh-6d16CpR8x7ZumJGFnn0Cs_y8vLwuP16tzhcr1ofIUkSXRpwSG8PkU4h-WjM_scHFNbItEuGQE6ibB588vWGO0Y4Sjm4fHXHr8Rtz0y0bMbnSTW7YkaenxaPeDYTP7s-zYrW8Wi3elTcfrt8vLm7KrmoglVI3um2QI-_RKNGirDup6r42tZLKOOwUB4kVcK2gV6aVXGPfyhaEaKtenhVvD7GbuR3xtss1ohvsJvrRxZ0Nztu_Xyb_xa7D1prKVKBEDnh1HxDD1xkp2dFTh8PgJgwzWVELAQ3oSmb05T_oXZhj7runtM4QyDpT4kB1MRBF7I_LALd7u_Zg12a79qdda_LQiz9rHEd-6cyAPAC02fvB-Pvv_8T-AJw6sNQ</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>van der Geest, K. S. M.</creator><creator>Treglia, G.</creator><creator>Glaudemans, A. W. J. M.</creator><creator>Brouwer, E.</creator><creator>Sandovici, M.</creator><creator>Jamar, F.</creator><creator>Gheysens, O.</creator><creator>Slart, R. H. J. A.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211101</creationdate><title>Diagnostic value of [18F]FDG-PET/CT for treatment monitoring in large vessel vasculitis: a systematic review and meta-analysis</title><author>van der Geest, K. S. M. ; Treglia, G. ; Glaudemans, A. W. J. M. ; Brouwer, E. ; Sandovici, M. ; Jamar, F. ; Gheysens, O. ; Slart, R. H. J. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-3797b9e0e0fe862be35c365f5856368aec6013e410761f68b307efb3b122b4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Arteritis</topic><topic>Bivariate analysis</topic><topic>Cardiology</topic><topic>Clinical aspects</topic><topic>Computed tomography</topic><topic>Cross-Sectional Studies</topic><topic>Fluorine isotopes</topic><topic>Fluorodeoxyglucose F18</topic><topic>Health services</topic><topic>Heterogeneity</topic><topic>Humans</topic><topic>Imaging</topic><topic>Infection and inflammation</topic><topic>Medical diagnosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Monitoring</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Orthopedics</topic><topic>Patients</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Positron Emission Tomography Computed Tomography</topic><topic>Radiology</topic><topic>Radiopharmaceuticals</topic><topic>Remission</topic><topic>Remission (Medicine)</topic><topic>Review</topic><topic>Review Article</topic><topic>Systematic review</topic><topic>Takayasu's disease</topic><topic>Telemedicine</topic><topic>Tomography</topic><topic>Vasculitis</topic><topic>Vein & artery diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van der Geest, K. S. M.</creatorcontrib><creatorcontrib>Treglia, G.</creatorcontrib><creatorcontrib>Glaudemans, A. W. J. M.</creatorcontrib><creatorcontrib>Brouwer, E.</creatorcontrib><creatorcontrib>Sandovici, M.</creatorcontrib><creatorcontrib>Jamar, F.</creatorcontrib><creatorcontrib>Gheysens, O.</creatorcontrib><creatorcontrib>Slart, R. H. J. A.</creatorcontrib><collection>Springer_OA刊</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database (ProQuest)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Database (1962 - current)</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van der Geest, K. S. M.</au><au>Treglia, G.</au><au>Glaudemans, A. W. J. M.</au><au>Brouwer, E.</au><au>Sandovici, M.</au><au>Jamar, F.</au><au>Gheysens, O.</au><au>Slart, R. H. J. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic value of [18F]FDG-PET/CT for treatment monitoring in large vessel vasculitis: a systematic review and meta-analysis</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><stitle>Eur J Nucl Med Mol Imaging</stitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>48</volume><issue>12</issue><spage>3886</spage><epage>3902</epage><pages>3886-3902</pages><issn>1619-7070</issn><eissn>1619-7089</eissn><abstract>Purpose
Monitoring disease activity in patients with large vessel vasculitis (LVV) can be challenging. [18F]FDG-PET/CT is increasingly used to evaluate treatment response in LVV. In this systematic review and meta-analysis, we aimed to summarize the current evidence on the value of [18F]FDG-PET/CT for treatment monitoring in LVV.
Methods
PubMed/MEDLINE and the Cochrane library database were searched from inception through October 21, 2020. Studies containing patients with LVV (i.e. giant cell arteritis, Takayasu arteritis and isolated aortitis) that received treatment and underwent [18F]FDG-PET/CT were included. Screening, full-text review and data extraction were performed by 2 investigators. The risk of bias was examined with the QUADAS-2 tool. Meta-analysis of proportions and diagnostic test accuracy was performed by a random-effects model and bivariate model, respectively.
Results
Twenty-one studies were included in the systematic review, of which 8 studies were eligible for meta-analysis. Arterial [18F]FDG uptake decreased upon clinical remission in longitudinal studies. High heterogeneity (
I
2
statistic 94%) precluded meta-analysis of the proportion of patients in which the scan normalized during clinical remission. Meta-analysis of cross-sectional studies indicated that [18F]FDG-PET/CT may detect relapsing/refractory disease with a sensitivity of 77% (95%CI 57–90%) and specificity of 71% (95%CI 47–87%). Substantial heterogeneity was observed among the cross-sectional studies. Both variation in clinical aspects and imaging procedures contributed to the heterogeneity.
Conclusion
Treatment of LVV leads to reduction of arterial [18F]FDG uptake during clinical remission. [18F]FDG-PET/CT has moderate diagnostic accuracy for detecting active LVV. [18F]FDG-PET/CT may aid treatment monitoring in LVV, but its findings should be interpreted in the context of the clinical suspicion of disease activity. This study underlines the relevance of published procedural recommendations for the use of [18F]FDG-PET/CT in LVV.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33942141</pmid><doi>10.1007/s00259-021-05362-8</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | European journal of nuclear medicine and molecular imaging, 2021-11, Vol.48 (12), p.3886-3902 |
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| source | MEDLINE; SpringerLink_现刊 |
| subjects | Arteritis Bivariate analysis Cardiology Clinical aspects Computed tomography Cross-Sectional Studies Fluorine isotopes Fluorodeoxyglucose F18 Health services Heterogeneity Humans Imaging Infection and inflammation Medical diagnosis Medicine Medicine & Public Health Meta-analysis Monitoring Nuclear Medicine Oncology Orthopedics Patients Positron emission Positron emission tomography Positron Emission Tomography Computed Tomography Radiology Radiopharmaceuticals Remission Remission (Medicine) Review Review Article Systematic review Takayasu's disease Telemedicine Tomography Vasculitis Vein & artery diseases |
| title | Diagnostic value of [18F]FDG-PET/CT for treatment monitoring in large vessel vasculitis: a systematic review and meta-analysis |
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