In-hospital use of ACE inhibitors/angiotensin receptor blockers associates with COVID-19 outcomes in African American patients

BACKGROUNDThe angiotensin-converting enzyme (ACE) D allele is more prevalent among African Americans compared with other races and ethnicities and has previously been associated with severe coronavirus disease 2019 (COVID-19) pathogenesis through excessive ACE1 activity. ACE inhibitors/angiotensin r...

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Veröffentlicht in:	The Journal of clinical investigation 2021-10, Vol.131 (19)
Hauptverfasser:	Li, Shilong, Sarangarajan, Rangaprasad, Jun, Tomi, Kao, Yu-Han, Wang, Zichen, Hao, Ke, Schadt, Emilio, Kiebish, Michael A, Granger, Elder, Narain, Niven R, Chen, Rong, Schadt, Eric E, Li, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE inhibitors African Americans Aged Angiotensin Receptor Antagonists - administration & dosage Angiotensin-Converting Enzyme Inhibitors - administration & dosage Clinical Medicine COVID-19 - drug therapy COVID-19 - ethnology COVID-19 - metabolism COVID-19 - mortality Disease-Free Survival Drug therapy Female Hospital Mortality - ethnology Hospital patients Humans Male Middle Aged Peptidyl-Dipeptidase A - metabolism Retrospective Studies SARS-CoV-2 - metabolism Survival Rate
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