The effect of 24-week continuous intake of quercetin-rich onion on age-related cognitive decline in healthy elderly people: a randomized, double-blind, placebo-controlled, parallel-group comparative clinical trial
Quercetin, a type of flavonoid, is believed to reduce age-related cognitive decline. To elucidate its potential function, we carried out a randomized, double-blind, placebo-controlled, parallel-group comparative clinical trial involving 24-week continuous intake of quercetin-rich onion compared to q...
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| Veröffentlicht in: | Journal of Clinical Biochemistry and Nutrition 2021, Vol.69(2), pp.203-215 |
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| container_title | Journal of Clinical Biochemistry and Nutrition |
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| creator | Nishihira, Jun Nishimura, Mie Kurimoto, Masanori Kagami-Katsuyama, Hiroyo Hattori, Hiroki Nakagawa, Toshiyuki Muro, Takato Kobori, Masuko |
| description | Quercetin, a type of flavonoid, is believed to reduce age-related cognitive decline. To elucidate its potential function, we carried out a randomized, double-blind, placebo-controlled, parallel-group comparative clinical trial involving 24-week continuous intake of quercetin-rich onion compared to quercetin-free onion as a placebo. Seventy healthy Japanese individuals (aged 60 to 79 years old) were enrolled in this study. We examined the effect of quercetin-rich onion (the active test food) on cognitive function using the Mini-Mental State Examination, Cognitive Assessment for Dementia iPad version, and Neuropsychiatric Inventory Nursing Home version. The Mini-Mental State Examination scores were significantly improved in the active test food group (daily quercetin intake, 50 mg as aglycone equivalent) compared to the placebo food group after 24 weeks. On the Cognitive Assessment for Dementia iPad version for emotional function evaluation, we found that the scores of the active test food group were significantly improved, suggesting that quercetin prevents cognitive decline by improving depressive symptoms and elevating motivation. On the Neuropsychiatric Inventory Nursing Home version, we found significant effects on reducing the burden on study partners. Taking all the data together, we concluded that 24-week continuous intake of quercetin-rich onion reduces age-related cognitive decline, possibly by improving emotional conditions. Clinical trial register and their clinical registration number: This study was registered with UMIN (approval number UMIN000036276, 5 April 2019). |
| doi_str_mv | 10.3164/jcbn.21-17 |
| format | Article |
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To elucidate its potential function, we carried out a randomized, double-blind, placebo-controlled, parallel-group comparative clinical trial involving 24-week continuous intake of quercetin-rich onion compared to quercetin-free onion as a placebo. Seventy healthy Japanese individuals (aged 60 to 79 years old) were enrolled in this study. We examined the effect of quercetin-rich onion (the active test food) on cognitive function using the Mini-Mental State Examination, Cognitive Assessment for Dementia iPad version, and Neuropsychiatric Inventory Nursing Home version. The Mini-Mental State Examination scores were significantly improved in the active test food group (daily quercetin intake, 50 mg as aglycone equivalent) compared to the placebo food group after 24 weeks. On the Cognitive Assessment for Dementia iPad version for emotional function evaluation, we found that the scores of the active test food group were significantly improved, suggesting that quercetin prevents cognitive decline by improving depressive symptoms and elevating motivation. On the Neuropsychiatric Inventory Nursing Home version, we found significant effects on reducing the burden on study partners. Taking all the data together, we concluded that 24-week continuous intake of quercetin-rich onion reduces age-related cognitive decline, possibly by improving emotional conditions. Clinical trial register and their clinical registration number: This study was registered with UMIN (approval number UMIN000036276, 5 April 2019).</description><identifier>ISSN: 0912-0009</identifier><identifier>EISSN: 1880-5086</identifier><identifier>DOI: 10.3164/jcbn.21-17</identifier><identifier>PMID: 34616111</identifier><language>eng</language><publisher>Gifu: SOCIETY FOR FREE RADICAL RESEARCH JAPAN</publisher><subject>Age ; CADi2 ; clinical trial ; Clinical trials ; Cognitive ability ; cognitive function ; Dementia ; Dementia disorders ; Double-blind studies ; Emotions ; Flavonoids ; Food ; Food intake ; MMSE ; Motivation ; NPI-NH ; Nursing homes ; onion ; Onions ; Original ; Placebos ; Quercetin ; Vegetables</subject><ispartof>Journal of Clinical Biochemistry and Nutrition, 2021, Vol.69(2), pp.203-215</ispartof><rights>2021 JCBN</rights><rights>2021. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2021 JCBN 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c595t-8041ea6e59ac47e6cefb66d95667efe3a852a171e1d42c8eb1f052c83492d2f13</citedby><cites>FETCH-LOGICAL-c595t-8041ea6e59ac47e6cefb66d95667efe3a852a171e1d42c8eb1f052c83492d2f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482389/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482389/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1876,4009,27902,27903,27904,53770,53772</link.rule.ids></links><search><creatorcontrib>Nishihira, Jun</creatorcontrib><creatorcontrib>Nishimura, Mie</creatorcontrib><creatorcontrib>Kurimoto, Masanori</creatorcontrib><creatorcontrib>Kagami-Katsuyama, Hiroyo</creatorcontrib><creatorcontrib>Hattori, Hiroki</creatorcontrib><creatorcontrib>Nakagawa, Toshiyuki</creatorcontrib><creatorcontrib>Muro, Takato</creatorcontrib><creatorcontrib>Kobori, Masuko</creatorcontrib><title>The effect of 24-week continuous intake of quercetin-rich onion on age-related cognitive decline in healthy elderly people: a randomized, double-blind, placebo-controlled, parallel-group comparative clinical trial</title><title>Journal of Clinical Biochemistry and Nutrition</title><addtitle>J. Clin. Biochem. Nutr.</addtitle><description>Quercetin, a type of flavonoid, is believed to reduce age-related cognitive decline. To elucidate its potential function, we carried out a randomized, double-blind, placebo-controlled, parallel-group comparative clinical trial involving 24-week continuous intake of quercetin-rich onion compared to quercetin-free onion as a placebo. Seventy healthy Japanese individuals (aged 60 to 79 years old) were enrolled in this study. We examined the effect of quercetin-rich onion (the active test food) on cognitive function using the Mini-Mental State Examination, Cognitive Assessment for Dementia iPad version, and Neuropsychiatric Inventory Nursing Home version. The Mini-Mental State Examination scores were significantly improved in the active test food group (daily quercetin intake, 50 mg as aglycone equivalent) compared to the placebo food group after 24 weeks. On the Cognitive Assessment for Dementia iPad version for emotional function evaluation, we found that the scores of the active test food group were significantly improved, suggesting that quercetin prevents cognitive decline by improving depressive symptoms and elevating motivation. On the Neuropsychiatric Inventory Nursing Home version, we found significant effects on reducing the burden on study partners. Taking all the data together, we concluded that 24-week continuous intake of quercetin-rich onion reduces age-related cognitive decline, possibly by improving emotional conditions. Clinical trial register and their clinical registration number: This study was registered with UMIN (approval number UMIN000036276, 5 April 2019).</description><subject>Age</subject><subject>CADi2</subject><subject>clinical trial</subject><subject>Clinical trials</subject><subject>Cognitive ability</subject><subject>cognitive function</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Double-blind studies</subject><subject>Emotions</subject><subject>Flavonoids</subject><subject>Food</subject><subject>Food intake</subject><subject>MMSE</subject><subject>Motivation</subject><subject>NPI-NH</subject><subject>Nursing homes</subject><subject>onion</subject><subject>Onions</subject><subject>Original</subject><subject>Placebos</subject><subject>Quercetin</subject><subject>Vegetables</subject><issn>0912-0009</issn><issn>1880-5086</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdks1u1DAQgCMEokvhwhNY4oIQLraTOA6HClTxJ1XiUs7WxJlsvPXawXGKlvfkfXC61UpwGY9nvvnxeIriJWcXJZfVu53p_IXglDePig1XitGaKfm42LCWC8oYa8-KZ_O8Y6yStayeFmdlJbnknG-KPzcjEhwGNImEgYiK_kK8JSb4ZP0SlplYn-AWV-fPBaPBbKfRmpEEb4PPksAWaUQHCfscuPU22TskPRpnPeZ4MiK4NB4Iuh6jO5AJw-TwPQESwfdhb39j_5b0Yekc0i5H5dvkwGAX6NpJDM6txAQRsuboNoZlyrX2q-W-2lrLGnAkRQvuefFkADfji4fzvPjx-dPN1Vd6_f3Lt6uP19TUbZ2oYhVHkFi3YKoGpcGhk7JvaykbHLAEVQvgDUfeV8Io7PjA6qyUVSt6MfDyvLg85p2Wbo-9wdwrOD1Fu4d40AGs_tfj7ai34U6rSolStTnB64cEMeTxzknv7WzQOfCYh69FrRjLQqqMvvoP3YUl-vy8TGU_Y7WqM_XmSJkY5jnicGqGM71ui163RQuueZPhD0d4N6f8iScUYrLG4RGVrRb3Yg05ucwIUaMv_wKcdM6B</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Nishihira, Jun</creator><creator>Nishimura, Mie</creator><creator>Kurimoto, Masanori</creator><creator>Kagami-Katsuyama, Hiroyo</creator><creator>Hattori, Hiroki</creator><creator>Nakagawa, Toshiyuki</creator><creator>Muro, Takato</creator><creator>Kobori, Masuko</creator><general>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</general><general>Japan Science and Technology Agency</general><general>the Society for Free Radical Research Japan</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2021</creationdate><title>The effect of 24-week continuous intake of quercetin-rich onion on age-related cognitive decline in healthy elderly people: a randomized, double-blind, placebo-controlled, parallel-group comparative clinical trial</title><author>Nishihira, Jun ; Nishimura, Mie ; Kurimoto, Masanori ; Kagami-Katsuyama, Hiroyo ; Hattori, Hiroki ; Nakagawa, Toshiyuki ; Muro, Takato ; Kobori, Masuko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c595t-8041ea6e59ac47e6cefb66d95667efe3a852a171e1d42c8eb1f052c83492d2f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>CADi2</topic><topic>clinical trial</topic><topic>Clinical trials</topic><topic>Cognitive ability</topic><topic>cognitive function</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>Double-blind studies</topic><topic>Emotions</topic><topic>Flavonoids</topic><topic>Food</topic><topic>Food intake</topic><topic>MMSE</topic><topic>Motivation</topic><topic>NPI-NH</topic><topic>Nursing homes</topic><topic>onion</topic><topic>Onions</topic><topic>Original</topic><topic>Placebos</topic><topic>Quercetin</topic><topic>Vegetables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishihira, Jun</creatorcontrib><creatorcontrib>Nishimura, Mie</creatorcontrib><creatorcontrib>Kurimoto, Masanori</creatorcontrib><creatorcontrib>Kagami-Katsuyama, Hiroyo</creatorcontrib><creatorcontrib>Hattori, Hiroki</creatorcontrib><creatorcontrib>Nakagawa, Toshiyuki</creatorcontrib><creatorcontrib>Muro, Takato</creatorcontrib><creatorcontrib>Kobori, Masuko</creatorcontrib><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishihira, Jun</au><au>Nishimura, Mie</au><au>Kurimoto, Masanori</au><au>Kagami-Katsuyama, Hiroyo</au><au>Hattori, Hiroki</au><au>Nakagawa, Toshiyuki</au><au>Muro, Takato</au><au>Kobori, Masuko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of 24-week continuous intake of quercetin-rich onion on age-related cognitive decline in healthy elderly people: a randomized, double-blind, placebo-controlled, parallel-group comparative clinical trial</atitle><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle><addtitle>J. Clin. Biochem. Nutr.</addtitle><date>2021</date><risdate>2021</risdate><volume>69</volume><issue>2</issue><spage>203</spage><epage>215</epage><pages>203-215</pages><artnum>21-17</artnum><issn>0912-0009</issn><eissn>1880-5086</eissn><abstract>Quercetin, a type of flavonoid, is believed to reduce age-related cognitive decline. To elucidate its potential function, we carried out a randomized, double-blind, placebo-controlled, parallel-group comparative clinical trial involving 24-week continuous intake of quercetin-rich onion compared to quercetin-free onion as a placebo. Seventy healthy Japanese individuals (aged 60 to 79 years old) were enrolled in this study. We examined the effect of quercetin-rich onion (the active test food) on cognitive function using the Mini-Mental State Examination, Cognitive Assessment for Dementia iPad version, and Neuropsychiatric Inventory Nursing Home version. The Mini-Mental State Examination scores were significantly improved in the active test food group (daily quercetin intake, 50 mg as aglycone equivalent) compared to the placebo food group after 24 weeks. On the Cognitive Assessment for Dementia iPad version for emotional function evaluation, we found that the scores of the active test food group were significantly improved, suggesting that quercetin prevents cognitive decline by improving depressive symptoms and elevating motivation. On the Neuropsychiatric Inventory Nursing Home version, we found significant effects on reducing the burden on study partners. Taking all the data together, we concluded that 24-week continuous intake of quercetin-rich onion reduces age-related cognitive decline, possibly by improving emotional conditions. Clinical trial register and their clinical registration number: This study was registered with UMIN (approval number UMIN000036276, 5 April 2019).</abstract><cop>Gifu</cop><pub>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</pub><pmid>34616111</pmid><doi>10.3164/jcbn.21-17</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age CADi2 clinical trial Clinical trials Cognitive ability cognitive function Dementia Dementia disorders Double-blind studies Emotions Flavonoids Food Food intake MMSE Motivation NPI-NH Nursing homes onion Onions Original Placebos Quercetin Vegetables |
| title | The effect of 24-week continuous intake of quercetin-rich onion on age-related cognitive decline in healthy elderly people: a randomized, double-blind, placebo-controlled, parallel-group comparative clinical trial |
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