Associated Factors With Uremic Pruritus in Chronic Hemodialysis Patients: A Single-Center Observational Study

Background and objectives Uremic pruritus is a recurrent and delicate manifestation in patients suffering from end-stage renal disease. It is a consequence of multiple factors, primarily comprising of metabolic factors and complement activation along with interleukins. The objective of our study was...

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Veröffentlicht in:Curēus (Palo Alto, CA) CA), 2021-08, Vol.13 (8), p.e17559-e17559
Hauptverfasser: Asghar, Muhammad Sohaib, Avinash, FNU, Singh, Manjeet, Siddiqui, Muhammad Ali, Hassan, Syed Adeel, Iqbal, Shahid, Irshad, Syeda Ghazala, Zehra, Mahrukh, Siddiqui, Kainat, Rasheed, Uzma
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container_issue 8
container_start_page e17559
container_title Curēus (Palo Alto, CA)
container_volume 13
creator Asghar, Muhammad Sohaib
Avinash, FNU
Singh, Manjeet
Siddiqui, Muhammad Ali
Hassan, Syed Adeel
Iqbal, Shahid
Irshad, Syeda Ghazala
Zehra, Mahrukh
Siddiqui, Kainat
Rasheed, Uzma
description Background and objectives Uremic pruritus is a recurrent and delicate manifestation in patients suffering from end-stage renal disease. It is a consequence of multiple factors, primarily comprising of metabolic factors and complement activation along with interleukins. The objective of our study was to find out the associated factors of uremic pruritus in chronic hemodialysis patients. The secondary aim was to obtain cut-off values of all the markers predicting pruritus. Materials and methods A cross-sectional observational study was conducted in the nephrology department of a tertiary care hospital including 135 patients. The current occurrence of pruritus was diagnosed on the basis of a validated and reliable scale of pruritus among chronic kidney disease (CKD) patients in the local language. Multivariate logistic regression and receiver operating characteristic analysis were conducted to decipher the required objectives. Results Study participants had a mean age of 56.29 ± 10.51 years with 56.3% males and 43.7% females. Hypertension was frequent comorbidity (75.6%) followed by diabetes (51.9%). Mean body mass index (BMI), duration of CKD diagnosis, and hemodialysis onset were 26.55 ± 5.37 kg/m 2 , 6.58 ± 3.65 years, and 3.32 ± 2.09 years respectively. Pruritus was reported in 37.0% of the study participants. On multivariate logistic regression, presence of skin allergy (aOR: 8.100 [2.926-22.420], p4.5 mg/dL (aOR: 3.889 [1.118-15.532], p=0.033), female gender (aOR: 3.592 [1.337-9.655], p=0.011), albumin 5.1 mEq/L (aOR: 2.934 [1.030-8.355], p=0.044) were found significantly associated with pruritus. Conclusion Many factors were linked to pruritus in hemodialysis patients in the current study. The current study also significantly correlated certain factors with pruritus independently.
doi_str_mv 10.7759/cureus.17559
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It is a consequence of multiple factors, primarily comprising of metabolic factors and complement activation along with interleukins. The objective of our study was to find out the associated factors of uremic pruritus in chronic hemodialysis patients. The secondary aim was to obtain cut-off values of all the markers predicting pruritus. Materials and methods A cross-sectional observational study was conducted in the nephrology department of a tertiary care hospital including 135 patients. The current occurrence of pruritus was diagnosed on the basis of a validated and reliable scale of pruritus among chronic kidney disease (CKD) patients in the local language. Multivariate logistic regression and receiver operating characteristic analysis were conducted to decipher the required objectives. Results Study participants had a mean age of 56.29 ± 10.51 years with 56.3% males and 43.7% females. Hypertension was frequent comorbidity (75.6%) followed by diabetes (51.9%). Mean body mass index (BMI), duration of CKD diagnosis, and hemodialysis onset were 26.55 ± 5.37 kg/m 2 , 6.58 ± 3.65 years, and 3.32 ± 2.09 years respectively. Pruritus was reported in 37.0% of the study participants. On multivariate logistic regression, presence of skin allergy (aOR: 8.100 [2.926-22.420], p&lt;0.001), phosphate &gt;4.5 mg/dL (aOR: 3.889 [1.118-15.532], p=0.033), female gender (aOR: 3.592 [1.337-9.655], p=0.011), albumin &lt;3.5 g/dL (aOR: 2.987 [1.156-7.716], p=0.024) and potassium &gt;5.1 mEq/L (aOR: 2.934 [1.030-8.355], p=0.044) were found significantly associated with pruritus. Conclusion Many factors were linked to pruritus in hemodialysis patients in the current study. The current study also significantly correlated certain factors with pruritus independently.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.17559</identifier><identifier>PMID: 34646616</identifier><language>eng</language><publisher>Palo Alto (CA): Cureus</publisher><subject>Allergy/Immunology ; Internal Medicine ; Nephrology</subject><ispartof>Curēus (Palo Alto, CA), 2021-08, Vol.13 (8), p.e17559-e17559</ispartof><rights>Copyright © 2021, Asghar et al. 2021 Asghar et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c248t-83d6c9a01a43ec00e7074df7ac7561747f550d561bdbac05f2fc198ab6cc97a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481143/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481143/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Asghar, Muhammad Sohaib</creatorcontrib><creatorcontrib>Avinash, FNU</creatorcontrib><creatorcontrib>Singh, Manjeet</creatorcontrib><creatorcontrib>Siddiqui, Muhammad Ali</creatorcontrib><creatorcontrib>Hassan, Syed Adeel</creatorcontrib><creatorcontrib>Iqbal, Shahid</creatorcontrib><creatorcontrib>Irshad, Syeda Ghazala</creatorcontrib><creatorcontrib>Zehra, Mahrukh</creatorcontrib><creatorcontrib>Siddiqui, Kainat</creatorcontrib><creatorcontrib>Rasheed, Uzma</creatorcontrib><title>Associated Factors With Uremic Pruritus in Chronic Hemodialysis Patients: A Single-Center Observational Study</title><title>Curēus (Palo Alto, CA)</title><description>Background and objectives Uremic pruritus is a recurrent and delicate manifestation in patients suffering from end-stage renal disease. It is a consequence of multiple factors, primarily comprising of metabolic factors and complement activation along with interleukins. The objective of our study was to find out the associated factors of uremic pruritus in chronic hemodialysis patients. The secondary aim was to obtain cut-off values of all the markers predicting pruritus. Materials and methods A cross-sectional observational study was conducted in the nephrology department of a tertiary care hospital including 135 patients. The current occurrence of pruritus was diagnosed on the basis of a validated and reliable scale of pruritus among chronic kidney disease (CKD) patients in the local language. Multivariate logistic regression and receiver operating characteristic analysis were conducted to decipher the required objectives. Results Study participants had a mean age of 56.29 ± 10.51 years with 56.3% males and 43.7% females. Hypertension was frequent comorbidity (75.6%) followed by diabetes (51.9%). Mean body mass index (BMI), duration of CKD diagnosis, and hemodialysis onset were 26.55 ± 5.37 kg/m 2 , 6.58 ± 3.65 years, and 3.32 ± 2.09 years respectively. Pruritus was reported in 37.0% of the study participants. On multivariate logistic regression, presence of skin allergy (aOR: 8.100 [2.926-22.420], p&lt;0.001), phosphate &gt;4.5 mg/dL (aOR: 3.889 [1.118-15.532], p=0.033), female gender (aOR: 3.592 [1.337-9.655], p=0.011), albumin &lt;3.5 g/dL (aOR: 2.987 [1.156-7.716], p=0.024) and potassium &gt;5.1 mEq/L (aOR: 2.934 [1.030-8.355], p=0.044) were found significantly associated with pruritus. Conclusion Many factors were linked to pruritus in hemodialysis patients in the current study. The current study also significantly correlated certain factors with pruritus independently.</description><subject>Allergy/Immunology</subject><subject>Internal Medicine</subject><subject>Nephrology</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpVUcFKxDAUDKK4onvzA3L0YDVp0yb1ICxFXWFhBV08hjRNdyNto3mJsH9v1xXR05v3Zph5MAidU3LFeV5e6-hNhCvK87w8QCcpLUQiqGCHf_AETQHeCCGU8JRwcowmGStYUdDiBPUzAKetCqbB90oH5wG_2rDBK296q_GTj96GCNgOuNp4N4y3ueldY1W3BQv4SQVrhgA3eIaf7bDuTFKNu_F4WYPxnyPtBtXh5xCb7Rk6alUHZvozT9Hq_u6lmieL5cNjNVskOmUiJCJrCl0qQhXLjCbEcMJZ03KleV5Qznib56QZYd3USpO8TVtNS6HqQuuSqyw7Rbd73_dY96bR40NedfLd2175rXTKyv_MYDdy7T6lYIJStjO4-DHw7iMaCLK3oE3XqcG4CDLNRUpJmZVilF7updo7AG_a3xhK5K4kuS9JfpeUfQHx1Idn</recordid><startdate>20210830</startdate><enddate>20210830</enddate><creator>Asghar, Muhammad Sohaib</creator><creator>Avinash, FNU</creator><creator>Singh, Manjeet</creator><creator>Siddiqui, Muhammad Ali</creator><creator>Hassan, Syed Adeel</creator><creator>Iqbal, Shahid</creator><creator>Irshad, Syeda Ghazala</creator><creator>Zehra, Mahrukh</creator><creator>Siddiqui, Kainat</creator><creator>Rasheed, Uzma</creator><general>Cureus</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210830</creationdate><title>Associated Factors With Uremic Pruritus in Chronic Hemodialysis Patients: A Single-Center Observational Study</title><author>Asghar, Muhammad Sohaib ; Avinash, FNU ; Singh, Manjeet ; Siddiqui, Muhammad Ali ; Hassan, Syed Adeel ; Iqbal, Shahid ; Irshad, Syeda Ghazala ; Zehra, Mahrukh ; Siddiqui, Kainat ; Rasheed, Uzma</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c248t-83d6c9a01a43ec00e7074df7ac7561747f550d561bdbac05f2fc198ab6cc97a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Allergy/Immunology</topic><topic>Internal Medicine</topic><topic>Nephrology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asghar, Muhammad Sohaib</creatorcontrib><creatorcontrib>Avinash, FNU</creatorcontrib><creatorcontrib>Singh, Manjeet</creatorcontrib><creatorcontrib>Siddiqui, Muhammad Ali</creatorcontrib><creatorcontrib>Hassan, Syed Adeel</creatorcontrib><creatorcontrib>Iqbal, Shahid</creatorcontrib><creatorcontrib>Irshad, Syeda Ghazala</creatorcontrib><creatorcontrib>Zehra, Mahrukh</creatorcontrib><creatorcontrib>Siddiqui, Kainat</creatorcontrib><creatorcontrib>Rasheed, Uzma</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asghar, Muhammad Sohaib</au><au>Avinash, FNU</au><au>Singh, Manjeet</au><au>Siddiqui, Muhammad Ali</au><au>Hassan, Syed Adeel</au><au>Iqbal, Shahid</au><au>Irshad, Syeda Ghazala</au><au>Zehra, Mahrukh</au><au>Siddiqui, Kainat</au><au>Rasheed, Uzma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associated Factors With Uremic Pruritus in Chronic Hemodialysis Patients: A Single-Center Observational Study</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><date>2021-08-30</date><risdate>2021</risdate><volume>13</volume><issue>8</issue><spage>e17559</spage><epage>e17559</epage><pages>e17559-e17559</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Background and objectives Uremic pruritus is a recurrent and delicate manifestation in patients suffering from end-stage renal disease. It is a consequence of multiple factors, primarily comprising of metabolic factors and complement activation along with interleukins. The objective of our study was to find out the associated factors of uremic pruritus in chronic hemodialysis patients. The secondary aim was to obtain cut-off values of all the markers predicting pruritus. Materials and methods A cross-sectional observational study was conducted in the nephrology department of a tertiary care hospital including 135 patients. The current occurrence of pruritus was diagnosed on the basis of a validated and reliable scale of pruritus among chronic kidney disease (CKD) patients in the local language. Multivariate logistic regression and receiver operating characteristic analysis were conducted to decipher the required objectives. Results Study participants had a mean age of 56.29 ± 10.51 years with 56.3% males and 43.7% females. Hypertension was frequent comorbidity (75.6%) followed by diabetes (51.9%). Mean body mass index (BMI), duration of CKD diagnosis, and hemodialysis onset were 26.55 ± 5.37 kg/m 2 , 6.58 ± 3.65 years, and 3.32 ± 2.09 years respectively. Pruritus was reported in 37.0% of the study participants. On multivariate logistic regression, presence of skin allergy (aOR: 8.100 [2.926-22.420], p&lt;0.001), phosphate &gt;4.5 mg/dL (aOR: 3.889 [1.118-15.532], p=0.033), female gender (aOR: 3.592 [1.337-9.655], p=0.011), albumin &lt;3.5 g/dL (aOR: 2.987 [1.156-7.716], p=0.024) and potassium &gt;5.1 mEq/L (aOR: 2.934 [1.030-8.355], p=0.044) were found significantly associated with pruritus. Conclusion Many factors were linked to pruritus in hemodialysis patients in the current study. The current study also significantly correlated certain factors with pruritus independently.</abstract><cop>Palo Alto (CA)</cop><pub>Cureus</pub><pmid>34646616</pmid><doi>10.7759/cureus.17559</doi><oa>free_for_read</oa></addata></record>
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subjects Allergy/Immunology
Internal Medicine
Nephrology
title Associated Factors With Uremic Pruritus in Chronic Hemodialysis Patients: A Single-Center Observational Study
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