Aerobic Exercise Improves Microvascular Function in Older Adults
Microvascular function is reduced with age, disease, and inactivity. Exercise is well known to improve vascular health and has the potential to improve microvascular function in aging and disease. PURPOSEThe study aimed to assess changes in peripheral microvascular function in sedentary older adults...
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| Veröffentlicht in: | Medicine and science in sports and exercise 2019-04, Vol.51 (4), p.773-781 |
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| creator | HURLEY, DAVID M WILLIAMS, EWAN R CROSS, JEFF M RIEDINGER, BRADLEY R MEYER, RONALD A ABELA, GEORGE S SLADE, JILL M |
| description | Microvascular function is reduced with age, disease, and inactivity. Exercise is well known to improve vascular health and has the potential to improve microvascular function in aging and disease.
PURPOSEThe study aimed to assess changes in peripheral microvascular function in sedentary older adults after aerobic exercise training.
METHODSTwenty-three sedentary older adults (67 ± 5 yr, body mass index = 29 ± 5, mean ± SD) successfully completed a randomized 12-wk graded treadmill walking intervention. The exercise group (EX) performed 40 min of uphill walking 4 d·wk at 70% heart rate reserve. The control group (CON) maintained a sedentary lifestyle for 12 wk. Blood oxygen level–dependent (BOLD) responses of the soleus measured by magnetic resonance imaging were used to evaluate microvascular function; brief (1 s) maximal plantarflexion contractions were performed. Separately, blood flow in the popliteal artery was measured by ultrasound after brief contraction. Phosphorus magnetic resonance spectroscopy of the calf was used to examine muscle oxidative capacity, and whole-body peak oxygen consumption (V˙O2peak) was used to confirm training-induced cardiorespiratory adaptations.
RESULTSPeak postcontraction BOLD response increased by 33% in EX (PRE, 3.3% ± 1.0%; POST, 4.4% ± 1.4%) compared with CON (PRE, 3.0% ± 1.3%; POST, 3.2% ± 1.5%), P < 0.05. EX with hypertension tended to show a blunted peak BOLD increase (n = 6, 15%) compared with EX normotensive (n = 7, 50%), P = 0.056. Peak postcontraction blood flow increased by 39% in EX (PRE, 217 ± 88 mL·min; POST, 302 ± 167 mL·min) compared with CON (PRE, 188 ± 54 mL·min; POST, 184 ± 44 mL·min), P < 0.05. EX muscle oxidative capacity (kPCr) improved by 40% (PRE, 1.60 ± 0.57 min; POST, 2.25 ± 0.80 min) compared with CON (PRE, 1.69 ± 0.28 min; POST, 1.76 ± 0.52 min), P < 0.05. V˙O2peak increased by 9% for EX (PRE, 19.0 ± 3.1 mL·kg·min; POST, 20.8 ± 2.9 mL·kg·min) compared with a 7% loss in CON (PRE, 21.9 ± 3.6 mL·kg·min; POST, 20.4 ± 3.5 mL·kg·min), P < 0.05.
CONCLUSIONModerate aerobic exercise significantly improved microvascular function of the leg in older adults. |
| doi_str_mv | 10.1249/MSS.0000000000001854 |
| format | Article |
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PURPOSEThe study aimed to assess changes in peripheral microvascular function in sedentary older adults after aerobic exercise training.
METHODSTwenty-three sedentary older adults (67 ± 5 yr, body mass index = 29 ± 5, mean ± SD) successfully completed a randomized 12-wk graded treadmill walking intervention. The exercise group (EX) performed 40 min of uphill walking 4 d·wk at 70% heart rate reserve. The control group (CON) maintained a sedentary lifestyle for 12 wk. Blood oxygen level–dependent (BOLD) responses of the soleus measured by magnetic resonance imaging were used to evaluate microvascular function; brief (1 s) maximal plantarflexion contractions were performed. Separately, blood flow in the popliteal artery was measured by ultrasound after brief contraction. Phosphorus magnetic resonance spectroscopy of the calf was used to examine muscle oxidative capacity, and whole-body peak oxygen consumption (V˙O2peak) was used to confirm training-induced cardiorespiratory adaptations.
RESULTSPeak postcontraction BOLD response increased by 33% in EX (PRE, 3.3% ± 1.0%; POST, 4.4% ± 1.4%) compared with CON (PRE, 3.0% ± 1.3%; POST, 3.2% ± 1.5%), P < 0.05. EX with hypertension tended to show a blunted peak BOLD increase (n = 6, 15%) compared with EX normotensive (n = 7, 50%), P = 0.056. Peak postcontraction blood flow increased by 39% in EX (PRE, 217 ± 88 mL·min; POST, 302 ± 167 mL·min) compared with CON (PRE, 188 ± 54 mL·min; POST, 184 ± 44 mL·min), P < 0.05. EX muscle oxidative capacity (kPCr) improved by 40% (PRE, 1.60 ± 0.57 min; POST, 2.25 ± 0.80 min) compared with CON (PRE, 1.69 ± 0.28 min; POST, 1.76 ± 0.52 min), P < 0.05. V˙O2peak increased by 9% for EX (PRE, 19.0 ± 3.1 mL·kg·min; POST, 20.8 ± 2.9 mL·kg·min) compared with a 7% loss in CON (PRE, 21.9 ± 3.6 mL·kg·min; POST, 20.4 ± 3.5 mL·kg·min), P < 0.05.
CONCLUSIONModerate aerobic exercise significantly improved microvascular function of the leg in older adults.</description><identifier>ISSN: 0195-9131</identifier><identifier>EISSN: 1530-0315</identifier><identifier>DOI: 10.1249/MSS.0000000000001854</identifier><identifier>PMID: 30489496</identifier><language>eng</language><publisher>United States: American College of Sports Medicine</publisher><subject>Aged - physiology ; Aged, 80 and over ; Exercise - physiology ; Humans ; Leg - blood supply ; Leg - physiology ; Magnetic Resonance Spectroscopy ; Microcirculation - physiology ; Middle Aged ; Muscle Contraction - physiology ; Muscle, Skeletal - blood supply ; Oxygen Consumption ; Physical Conditioning, Human ; Popliteal Artery - diagnostic imaging ; Popliteal Artery - physiology ; Regional Blood Flow ; Sedentary Behavior ; Ultrasonography ; Vasodilation - physiology</subject><ispartof>Medicine and science in sports and exercise, 2019-04, Vol.51 (4), p.773-781</ispartof><rights>2019 American College of Sports Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4574-e035eb80612642d73711adb916e64c7fc82733fb59938dd80453b064e197660c3</citedby><cites>FETCH-LOGICAL-c4574-e035eb80612642d73711adb916e64c7fc82733fb59938dd80453b064e197660c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30489496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HURLEY, DAVID M</creatorcontrib><creatorcontrib>WILLIAMS, EWAN R</creatorcontrib><creatorcontrib>CROSS, JEFF M</creatorcontrib><creatorcontrib>RIEDINGER, BRADLEY R</creatorcontrib><creatorcontrib>MEYER, RONALD A</creatorcontrib><creatorcontrib>ABELA, GEORGE S</creatorcontrib><creatorcontrib>SLADE, JILL M</creatorcontrib><title>Aerobic Exercise Improves Microvascular Function in Older Adults</title><title>Medicine and science in sports and exercise</title><addtitle>Med Sci Sports Exerc</addtitle><description>Microvascular function is reduced with age, disease, and inactivity. Exercise is well known to improve vascular health and has the potential to improve microvascular function in aging and disease.
PURPOSEThe study aimed to assess changes in peripheral microvascular function in sedentary older adults after aerobic exercise training.
METHODSTwenty-three sedentary older adults (67 ± 5 yr, body mass index = 29 ± 5, mean ± SD) successfully completed a randomized 12-wk graded treadmill walking intervention. The exercise group (EX) performed 40 min of uphill walking 4 d·wk at 70% heart rate reserve. The control group (CON) maintained a sedentary lifestyle for 12 wk. Blood oxygen level–dependent (BOLD) responses of the soleus measured by magnetic resonance imaging were used to evaluate microvascular function; brief (1 s) maximal plantarflexion contractions were performed. Separately, blood flow in the popliteal artery was measured by ultrasound after brief contraction. Phosphorus magnetic resonance spectroscopy of the calf was used to examine muscle oxidative capacity, and whole-body peak oxygen consumption (V˙O2peak) was used to confirm training-induced cardiorespiratory adaptations.
RESULTSPeak postcontraction BOLD response increased by 33% in EX (PRE, 3.3% ± 1.0%; POST, 4.4% ± 1.4%) compared with CON (PRE, 3.0% ± 1.3%; POST, 3.2% ± 1.5%), P < 0.05. EX with hypertension tended to show a blunted peak BOLD increase (n = 6, 15%) compared with EX normotensive (n = 7, 50%), P = 0.056. Peak postcontraction blood flow increased by 39% in EX (PRE, 217 ± 88 mL·min; POST, 302 ± 167 mL·min) compared with CON (PRE, 188 ± 54 mL·min; POST, 184 ± 44 mL·min), P < 0.05. EX muscle oxidative capacity (kPCr) improved by 40% (PRE, 1.60 ± 0.57 min; POST, 2.25 ± 0.80 min) compared with CON (PRE, 1.69 ± 0.28 min; POST, 1.76 ± 0.52 min), P < 0.05. V˙O2peak increased by 9% for EX (PRE, 19.0 ± 3.1 mL·kg·min; POST, 20.8 ± 2.9 mL·kg·min) compared with a 7% loss in CON (PRE, 21.9 ± 3.6 mL·kg·min; POST, 20.4 ± 3.5 mL·kg·min), P < 0.05.
CONCLUSIONModerate aerobic exercise significantly improved microvascular function of the leg in older adults.</description><subject>Aged - physiology</subject><subject>Aged, 80 and over</subject><subject>Exercise - physiology</subject><subject>Humans</subject><subject>Leg - blood supply</subject><subject>Leg - physiology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Microcirculation - physiology</subject><subject>Middle Aged</subject><subject>Muscle Contraction - physiology</subject><subject>Muscle, Skeletal - blood supply</subject><subject>Oxygen Consumption</subject><subject>Physical Conditioning, Human</subject><subject>Popliteal Artery - diagnostic imaging</subject><subject>Popliteal Artery - physiology</subject><subject>Regional Blood Flow</subject><subject>Sedentary Behavior</subject><subject>Ultrasonography</subject><subject>Vasodilation - physiology</subject><issn>0195-9131</issn><issn>1530-0315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EglL4BwhlZEmxYzuxF0RVUUBqxQDMluNcqMFNip3w8e8xKlTAgJezdM-9d3oQOiJ4RDImT-e3tyP84xHB2RYaEE5xiinh22iAieSpJJTsof0QHiNUUEp20R7FTEgm8wE6H4NvS2uSizfwxgZIrpcr375ASObWxI8OpnfaJ9O-MZ1tm8Q2yY2rwCfjqnddOEA7tXYBDr_qEN1PL-4mV-ns5vJ6Mp6lhvGCpYAph1LgnGQ5y6qCFoToqpQkh5yZojYii7fVJZeSiqoSmHFa4pwBkUWeY0OH6Gydu-rLJVQGms5rp1beLrV_V6226nensQv10L4owUTUUcSAk68A3z73EDq1tMGAc7qBtg8qI1RyQWkmIsrWaBQQgod6s4Zg9SlfRfnqr_w4dvzzxM3Qt-0IiDXw2roOfHhy_St4tQDtusX_2R8jwJBL</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>HURLEY, DAVID M</creator><creator>WILLIAMS, EWAN R</creator><creator>CROSS, JEFF M</creator><creator>RIEDINGER, BRADLEY R</creator><creator>MEYER, RONALD A</creator><creator>ABELA, GEORGE S</creator><creator>SLADE, JILL M</creator><general>American College of Sports Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201904</creationdate><title>Aerobic Exercise Improves Microvascular Function in Older Adults</title><author>HURLEY, DAVID M ; WILLIAMS, EWAN R ; CROSS, JEFF M ; RIEDINGER, BRADLEY R ; MEYER, RONALD A ; ABELA, GEORGE S ; SLADE, JILL M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4574-e035eb80612642d73711adb916e64c7fc82733fb59938dd80453b064e197660c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged - physiology</topic><topic>Aged, 80 and over</topic><topic>Exercise - physiology</topic><topic>Humans</topic><topic>Leg - blood supply</topic><topic>Leg - physiology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Microcirculation - physiology</topic><topic>Middle Aged</topic><topic>Muscle Contraction - physiology</topic><topic>Muscle, Skeletal - blood supply</topic><topic>Oxygen Consumption</topic><topic>Physical Conditioning, Human</topic><topic>Popliteal Artery - diagnostic imaging</topic><topic>Popliteal Artery - physiology</topic><topic>Regional Blood Flow</topic><topic>Sedentary Behavior</topic><topic>Ultrasonography</topic><topic>Vasodilation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HURLEY, DAVID M</creatorcontrib><creatorcontrib>WILLIAMS, EWAN R</creatorcontrib><creatorcontrib>CROSS, JEFF M</creatorcontrib><creatorcontrib>RIEDINGER, BRADLEY R</creatorcontrib><creatorcontrib>MEYER, RONALD A</creatorcontrib><creatorcontrib>ABELA, GEORGE S</creatorcontrib><creatorcontrib>SLADE, JILL M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine and science in sports and exercise</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HURLEY, DAVID M</au><au>WILLIAMS, EWAN R</au><au>CROSS, JEFF M</au><au>RIEDINGER, BRADLEY R</au><au>MEYER, RONALD A</au><au>ABELA, GEORGE S</au><au>SLADE, JILL M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aerobic Exercise Improves Microvascular Function in Older Adults</atitle><jtitle>Medicine and science in sports and exercise</jtitle><addtitle>Med Sci Sports Exerc</addtitle><date>2019-04</date><risdate>2019</risdate><volume>51</volume><issue>4</issue><spage>773</spage><epage>781</epage><pages>773-781</pages><issn>0195-9131</issn><eissn>1530-0315</eissn><abstract>Microvascular function is reduced with age, disease, and inactivity. Exercise is well known to improve vascular health and has the potential to improve microvascular function in aging and disease.
PURPOSEThe study aimed to assess changes in peripheral microvascular function in sedentary older adults after aerobic exercise training.
METHODSTwenty-three sedentary older adults (67 ± 5 yr, body mass index = 29 ± 5, mean ± SD) successfully completed a randomized 12-wk graded treadmill walking intervention. The exercise group (EX) performed 40 min of uphill walking 4 d·wk at 70% heart rate reserve. The control group (CON) maintained a sedentary lifestyle for 12 wk. Blood oxygen level–dependent (BOLD) responses of the soleus measured by magnetic resonance imaging were used to evaluate microvascular function; brief (1 s) maximal plantarflexion contractions were performed. Separately, blood flow in the popliteal artery was measured by ultrasound after brief contraction. Phosphorus magnetic resonance spectroscopy of the calf was used to examine muscle oxidative capacity, and whole-body peak oxygen consumption (V˙O2peak) was used to confirm training-induced cardiorespiratory adaptations.
RESULTSPeak postcontraction BOLD response increased by 33% in EX (PRE, 3.3% ± 1.0%; POST, 4.4% ± 1.4%) compared with CON (PRE, 3.0% ± 1.3%; POST, 3.2% ± 1.5%), P < 0.05. EX with hypertension tended to show a blunted peak BOLD increase (n = 6, 15%) compared with EX normotensive (n = 7, 50%), P = 0.056. Peak postcontraction blood flow increased by 39% in EX (PRE, 217 ± 88 mL·min; POST, 302 ± 167 mL·min) compared with CON (PRE, 188 ± 54 mL·min; POST, 184 ± 44 mL·min), P < 0.05. EX muscle oxidative capacity (kPCr) improved by 40% (PRE, 1.60 ± 0.57 min; POST, 2.25 ± 0.80 min) compared with CON (PRE, 1.69 ± 0.28 min; POST, 1.76 ± 0.52 min), P < 0.05. V˙O2peak increased by 9% for EX (PRE, 19.0 ± 3.1 mL·kg·min; POST, 20.8 ± 2.9 mL·kg·min) compared with a 7% loss in CON (PRE, 21.9 ± 3.6 mL·kg·min; POST, 20.4 ± 3.5 mL·kg·min), P < 0.05.
CONCLUSIONModerate aerobic exercise significantly improved microvascular function of the leg in older adults.</abstract><cop>United States</cop><pub>American College of Sports Medicine</pub><pmid>30489496</pmid><doi>10.1249/MSS.0000000000001854</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete |
| subjects | Aged - physiology Aged, 80 and over Exercise - physiology Humans Leg - blood supply Leg - physiology Magnetic Resonance Spectroscopy Microcirculation - physiology Middle Aged Muscle Contraction - physiology Muscle, Skeletal - blood supply Oxygen Consumption Physical Conditioning, Human Popliteal Artery - diagnostic imaging Popliteal Artery - physiology Regional Blood Flow Sedentary Behavior Ultrasonography Vasodilation - physiology |
| title | Aerobic Exercise Improves Microvascular Function in Older Adults |
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