The microglial NLRP3 inflammasome is involved in human SARS-CoV-2 cerebral pathogenicity: A report of three post-mortem cases

We herein report, by using confocal immunofluorescence, the colocalization of the SARS-CoV-2 nucleocapsid within neurons, astrocytes, oligodendrocytes and microglia in three deceased COVID-19 cases, of between 78 and 85 years of age at death. The viral nucleocapsid was detected together with its ACE...

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Veröffentlicht in:	Journal of neuroimmunology 2021-12, Vol.361, p.577728-577728, Article 577728
Hauptverfasser:	Cama, Viviana Falcón, Marín-Prida, Javier, Acosta-Rivero, Nelson, Acosta, Emilio F., Díaz, Leonardo Oramas, Casadesús, Ana V., Fernández-Marrero, Briandy, Gilva-Rodríguez, Nathalie, Cremata-García, Daina, Cervantes-Llanos, Majel, Piniella-Matamoros, Beatriz, Sánchez, Daisy, del Rosario-Cruz, Leticia, Borrajero, Israel, Díaz, Angelina, González, Yorexis, Pentón-Arias, Eduardo, Montero-González, Teresita, Guillen-Nieto, Gerardo, Pentón-Rol, Giselle
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Astrocytes - virology Autopsy Brain - immunology Brain - pathology Brain - virology COVID-19 COVID-19 - immunology COVID-19 - pathology COVID-19 - virology Female Human brain Humans Inflammasomes - immunology Macrophages Male Microglia - immunology Microglia - virology Neurons - virology NLR Family, Pyrin Domain-Containing 3 Protein - immunology NLRP3 inflammasome Nucleocapsid Oligodendroglia - virology SARS-CoV-2 SARS-CoV-2 - pathogenicity Short Communication
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