Alkaline intracellular pH (pHi) activates AMPK–mTORC2 signaling to promote cell survival during growth factor limitation

The mechanistic target of rapamycin (mTOR) complex 2 (mTORC2) signaling controls cell metabolism, promotes cell survival, and contributes to tumorigenesis, yet its upstream regulation remains poorly defined. Although considerable evidence supports the prevailing view that amino acids activate mTOR c...

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Veröffentlicht in:	The Journal of biological chemistry 2021-10, Vol.297 (4), p.101100-101100, Article 101100
Hauptverfasser:	Kazyken, D., Lentz, S.I., Fingar, D.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Accelerated Communication Akt AMPK intracellular pH (pHi) mTORC2
Online-Zugang:	Volltext
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