Effect of Levetiracetam on Cognition in Patients With Alzheimer Disease With and Without Epileptiform Activity: A Randomized Clinical Trial

IMPORTANCE: Network hyperexcitability may contribute to cognitive dysfunction in patients with Alzheimer disease (AD). OBJECTIVE: To determine the ability of the antiseizure drug levetiracetam to improve cognition in persons with AD. DESIGN, SETTING, AND PARTICIPANTS: The Levetiracetam for Alzheimer...

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Veröffentlicht in:	Archives of neurology (Chicago) 2021-11, Vol.78 (11), p.1345-1354
Hauptverfasser:	Vossel, Keith, Ranasinghe, Kamalini G, Beagle, Alexander J, La, Alice, Ah Pook, Kasey, Castro, Madelyn, Mizuiri, Danielle, Honma, Susanne M, Venkateswaran, Nisha, Koestler, Mary, Zhang, Wenbo, Mucke, Lennart, Howell, Michael J, Possin, Katherine L, Kramer, Joel H, Boxer, Adam L, Miller, Bruce L, Nagarajan, Srikantan S, Kirsch, Heidi E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Adverse events Aged Aged, 80 and over Alzheimer Disease - complications Alzheimer Disease - drug therapy Alzheimer's disease Anticonvulsants - therapeutic use Clinical trials Cognition Cognition & reasoning Cognition - drug effects Cognitive ability Comments Cross-Over Studies Dementia disorders Double-Blind Method Drug development EEG Electroencephalography Epilepsy Etiracetam Executive function Executive Function - drug effects Exploratory behavior Female Functional testing Health services Humans Interference Learning Levetiracetam - therapeutic use Magnetoencephalography Male Memory tasks Middle Aged Naming Neurodegenerative diseases Online First Original Investigation Patients Placebos Seizures - etiology Spatial analysis Spatial memory
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