Genetics of substance use disorders: a review

Substance use disorders (SUDs) are prevalent and result in an array of negative consequences. They are influenced by genetic factors (h2 = ~50%). Recent years have brought substantial progress in our understanding of the genetic etiology of SUDs and related traits. The present review covers the curr...

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Veröffentlicht in:	Psychological medicine 2021-10, Vol.51 (13), p.2189-2200
Hauptverfasser:	Deak, Joseph D., Johnson, Emma C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Alcohol dehydrogenase Alcohol Dehydrogenase - genetics Alcohol use Alcoholism - genetics Aldehyde dehydrogenase Aldehyde Dehydrogenase, Mitochondrial - genetics Cannabis Cannabis - genetics Cocaine Drug abuse Drug use Drug withdrawal Endorsements Epidemiology Etiology Gene-Environment Interaction Genes Genetic factors Genetic relationship Genome-wide association studies Genome-Wide Association Study Genomes Genomics Humans Invited Review Marijuana Mental disorders Molecular Epidemiology Narcotics Nicotine Nicotine - genetics Opioids Polygenic inheritance Public health Quantitative genetics Socioeconomic factors Substance use disorder Substance-Related Disorders - epidemiology Substance-Related Disorders - etiology Substance-Related Disorders - genetics Twins Variants
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