Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation

Cells organize biochemical processes into biological condensates. P-bodies are cytoplasmic condensates that are enriched in enzymes important for mRNA degradation and have been identified as sites of both storage and decay. How these opposing outcomes can be achieved in condensates remains unresolve...

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Veröffentlicht in:	Nature chemical biology 2021-05, Vol.17 (5), p.615-623
Hauptverfasser:	Tibble, Ryan W., Depaix, Anaïs, Kowalska, Joanna, Jemielity, Jacek, Gross, John D.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/1645 631/45/173 631/535/878 Binding Sites Biochemical Engineering Biochemistry Biological activity Biology Bioorganic Chemistry Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science Cloning, Molecular Condensates Cytoplasmic Granules - chemistry Cytoplasmic Granules - metabolism Degradation Enzymatic activity Enzymes Escherichia coli - genetics Escherichia coli - metabolism Fluorescent Dyes - chemistry Gene Expression Genetic Vectors - chemistry Genetic Vectors - metabolism Localization Models, Molecular mRNA Phase separation Protein Binding Protein Conformation, alpha-Helical Protein Conformation, beta-Strand Protein interaction Protein Interaction Domains and Motifs Proteins Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Regulation Regulatory mechanisms (biology) RNA Caps - chemistry RNA Caps - genetics RNA Caps - metabolism RNA Stability Schizosaccharomyces - chemistry Schizosaccharomyces - metabolism Schizosaccharomyces pombe Proteins - chemistry Schizosaccharomyces pombe Proteins - genetics Schizosaccharomyces pombe Proteins - metabolism Staining and Labeling - methods Substrate Specificity Substrates
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