Evolution of delayed resistance to immunotherapy in a melanoma responder

Despite initial responses 1 – 3 , most melanoma patients develop resistance 4 to immune checkpoint blockade (ICB). To understand the evolution of resistance, we studied 37 tumor samples over 9 years from a patient with metastatic melanoma with complete clinical response to ICB followed by delayed re...

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Veröffentlicht in:	Nature medicine 2021-06, Vol.27 (6), p.985-992
Hauptverfasser:	Liu, David, Lin, Jia-Ren, Robitschek, Emily J., Kasumova, Gyulnara G., Heyde, Alex, Shi, Alvin, Kraya, Adam, Zhang, Gao, Moll, Tabea, Frederick, Dennie T., Chen, Yu-An, Wang, Shu, Schapiro, Denis, Ho, Li-Lun, Bi, Kevin, Sahu, Avinash, Mei, Shaolin, Miao, Benchun, Sharova, Tatyana, Alvarez-Breckenridge, Christopher, Stocking, Jackson H., Kim, Tommy, Fadden, Riley, Lawrence, Donald, Hoang, Mai P., Cahill, Daniel P., Malehmir, Mohsen, Nowak, Martin A., Brastianos, Priscilla K., Lian, Christine G., Ruppin, Eytan, Izar, Benjamin, Herlyn, Meenhard, Van Allen, Eliezer M., Nathanson, Katherine, Flaherty, Keith T., Sullivan, Ryan J., Kellis, Manolis, Sorger, Peter K., Boland, Genevieve M.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/2325 631/67/1059/2326 631/67/1813/1634 631/67/69 Autopsies Autopsy B7-H1 Antigen - antagonists & inhibitors B7-H1 Antigen - genetics B7-H1 Antigen - immunology Biochemistry & Molecular Biology Biomedical and Life Sciences Biomedicine Cancer Research Cell Biology Chromosome 15 Chromosomes, Human, Pair 15 - genetics Coevolution Drug Resistance, Neoplasm - drug effects Evolution Female Gene Expression Regulation, Neoplastic Gene sequencing Genetic analysis Humans Immune checkpoint inhibitors Immune Checkpoint Inhibitors - adverse effects Immune Checkpoint Inhibitors - therapeutic use Immune system Immunofluorescence Immunotherapy Immunotherapy - adverse effects Infectious Diseases Letter Life Sciences & Biomedicine Male Medicine, Research & Experimental Melanoma Melanoma - genetics Melanoma - immunology Melanoma - pathology Melanoma - therapy Metabolic Diseases Metastases Microenvironments Mimicry Molecular Medicine Neoplasm Metastasis Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - immunology Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - therapy Nerve growth factor receptors Nerve Tissue Proteins - genetics Nerve Tissue Proteins - immunology Neurosciences Patients PD-L1 protein Phenotypes Phylogeny Polarity Receptors, Nerve Growth Factor - genetics Receptors, Nerve Growth Factor - immunology Research & Experimental Medicine Science & Technology Tumor cells Tumor microenvironment Tumor Microenvironment - drug effects Tumors
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