Livin/BIRC7 gene expression as a possible diagnostic biomarker for endometrial hyperplasia and carcinoma
Background Livin/BIRC7 is a member of the inhibitors of apoptosis proteins family which are implicated in development of cancer through the inhibition of apoptosis process. This case-control study was intended to investigate livin/BIRC7 gene expression in endometrial hyperplasia and carcinoma and it...
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| Veröffentlicht in: | Journal of Genetic Engineering and Biotechnology 2021-09, Vol.19 (1), p.141-8, Article 141 |
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| creator | Elmekkawy, Basma K. Shoaib, Rasha M. S. Seleem, Amal K. Shaalan, Dalia Saad, Entsar A. |
| description | Background
Livin/BIRC7
is a member of the inhibitors of apoptosis proteins family which are implicated in development of cancer through the inhibition of apoptosis process. This case-control study was intended to investigate
livin/BIRC7
gene expression in endometrial hyperplasia and carcinoma and its correlation to some oxidative stress markers in addition to its possible diagnostic performance.
Methods
This study included 90 participants [30 endometrial hyperplasia patients, 30 endometrial carcinoma patients, and 30 healthy controls].
Livin/BIRC7
gene expression was analyzed using quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). Serum catalase activity was assessed by enzyme-linked immunosorbent assay (ELISA) and malondialdehyde level was measured by the colorimetric method.
Results
Livin/BIRC7
gene expression was significantly (
p
< 0.001) higher in endometrial carcinoma from patients with endometrial hyperplasia when compared to controls. A positive correlation was found between
livin/BIRC7
expression and serum catalase activity and malondialdehyde level in endometrial hyperplasia and carcinoma. The detection of
livin/BIRC7
in endometrial carcinoma has excellent sensitivity and specificity.
Conclusions
Livin/BIRC7
was overexpressed in endometrial carcinoma with excellent power to differentiate endometrial carcinoma from endometrial hyperplasia or healthy subjects, suggesting that it might be a useful molecular marker for endometrial carcinoma diagnosis. |
| doi_str_mv | 10.1186/s43141-021-00244-w |
| format | Article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8473530</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A679537990</galeid><doaj_id>oai_doaj_org_article_d6225b1f321e46a6a08e1693b4728a59</doaj_id><sourcerecordid>A679537990</sourcerecordid><originalsourceid>FETCH-LOGICAL-c607t-1b8b788e42d6b670db49f21f21682006521b29ffd03ab126b180e7758f488fc93</originalsourceid><addsrcrecordid>eNp9kl1rFDEUhgdR7FL7B7yQgNfT5muSzI1Ql6oLCwVR8C4kMyezWWeTMdlt7b83261tF8R8EJLznodzyFtVbwk-J0SJi8wZ4aTGtGxMOa9vX1QziltcNy3FL6sZEUrWpJE_TqqznNe4jIYr0pDX1QnjjVCtYrNqtfQ3Plx8XHydSzRAAAS_pwQ5-xiQycigKZaLHQH13gwh5q3vkPVxY9JPSMjFhCD0cQPb5M2IVncTpGk02RtkQo86kzofivpN9cqZMcPZw3laff909W3-pV5ef17ML5d1J7Dc1sQqK5UCTnthhcS95a2jpCyhKMaiocTS1rkeM2MJFZYoDFI2ynGlXNey02px4PbRrPWUfCn0Tkfj9f1DTIM2qfQwgu4FpY0ljlECXBhhsAIiWma5pMo0e9aHA2va2Q30HYRtMuMR9DgS_EoP8UYrLlnDcAG8fwCk-GsHeavXcZdC6V9TRSjjrAifVIMpVfngYoF1G587fSlk2zDZtnvW-T9UZfaw8V0M4Hx5P0qgh4QulS9M4B4LJ1jvPaQPHtLFQ_reQ_q2JL173vJjyl_HFAE7CHIJhQHSU0v_wf4BYgfQ-w</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2812343473</pqid></control><display><type>article</type><title>Livin/BIRC7 gene expression as a possible diagnostic biomarker for endometrial hyperplasia and carcinoma</title><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Elmekkawy, Basma K. ; Shoaib, Rasha M. S. ; Seleem, Amal K. ; Shaalan, Dalia ; Saad, Entsar A.</creator><creatorcontrib>Elmekkawy, Basma K. ; Shoaib, Rasha M. S. ; Seleem, Amal K. ; Shaalan, Dalia ; Saad, Entsar A.</creatorcontrib><description>Background
Livin/BIRC7
is a member of the inhibitors of apoptosis proteins family which are implicated in development of cancer through the inhibition of apoptosis process. This case-control study was intended to investigate
livin/BIRC7
gene expression in endometrial hyperplasia and carcinoma and its correlation to some oxidative stress markers in addition to its possible diagnostic performance.
Methods
This study included 90 participants [30 endometrial hyperplasia patients, 30 endometrial carcinoma patients, and 30 healthy controls].
Livin/BIRC7
gene expression was analyzed using quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). Serum catalase activity was assessed by enzyme-linked immunosorbent assay (ELISA) and malondialdehyde level was measured by the colorimetric method.
Results
Livin/BIRC7
gene expression was significantly (
p
< 0.001) higher in endometrial carcinoma from patients with endometrial hyperplasia when compared to controls. A positive correlation was found between
livin/BIRC7
expression and serum catalase activity and malondialdehyde level in endometrial hyperplasia and carcinoma. The detection of
livin/BIRC7
in endometrial carcinoma has excellent sensitivity and specificity.
Conclusions
Livin/BIRC7
was overexpressed in endometrial carcinoma with excellent power to differentiate endometrial carcinoma from endometrial hyperplasia or healthy subjects, suggesting that it might be a useful molecular marker for endometrial carcinoma diagnosis.</description><identifier>ISSN: 1687-157X</identifier><identifier>EISSN: 2090-5920</identifier><identifier>DOI: 10.1186/s43141-021-00244-w</identifier><identifier>PMID: 34568983</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Age ; Analysis ; Apoptosis ; Biomarkers ; Biomedical Engineering and Bioengineering ; BIRC7 ; Cancer ; Cancer therapies ; Carcinoma ; Catalase ; Cell cycle ; Colorimetry ; Development and progression ; Diagnostic systems ; DNA polymerases ; Endometrial cancer ; Endometrial carcinoma ; Endometrial hyperplasia ; Endometrium ; Engineering ; Enzyme-linked immunosorbent assay ; Enzymes ; Estrogens ; Gene expression ; Genes ; Genetic aspects ; Gynecology ; Hyperplasia ; IAP protein ; Livin ; Malondialdehyde ; Medical prognosis ; Menopause ; Obstetrics ; Oxidative stress ; Polymerase chain reaction ; Prevention ; Proteins ; RNA-directed DNA polymerase ; Signal transduction ; Uterine cancer</subject><ispartof>Journal of Genetic Engineering and Biotechnology, 2021-09, Vol.19 (1), p.141-8, Article 141</ispartof><rights>The Author(s) 2021. corrected publication 2022</rights><rights>2021. The Author(s).</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s) 2021. corrected publication 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2021, corrected publication 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c607t-1b8b788e42d6b670db49f21f21682006521b29ffd03ab126b180e7758f488fc93</citedby><cites>FETCH-LOGICAL-c607t-1b8b788e42d6b670db49f21f21682006521b29ffd03ab126b180e7758f488fc93</cites><orcidid>0000-0001-6477-8098</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473530/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473530/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34568983$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elmekkawy, Basma K.</creatorcontrib><creatorcontrib>Shoaib, Rasha M. S.</creatorcontrib><creatorcontrib>Seleem, Amal K.</creatorcontrib><creatorcontrib>Shaalan, Dalia</creatorcontrib><creatorcontrib>Saad, Entsar A.</creatorcontrib><title>Livin/BIRC7 gene expression as a possible diagnostic biomarker for endometrial hyperplasia and carcinoma</title><title>Journal of Genetic Engineering and Biotechnology</title><addtitle>J Genet Eng Biotechnol</addtitle><addtitle>J Genet Eng Biotechnol</addtitle><description>Background
Livin/BIRC7
is a member of the inhibitors of apoptosis proteins family which are implicated in development of cancer through the inhibition of apoptosis process. This case-control study was intended to investigate
livin/BIRC7
gene expression in endometrial hyperplasia and carcinoma and its correlation to some oxidative stress markers in addition to its possible diagnostic performance.
Methods
This study included 90 participants [30 endometrial hyperplasia patients, 30 endometrial carcinoma patients, and 30 healthy controls].
Livin/BIRC7
gene expression was analyzed using quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). Serum catalase activity was assessed by enzyme-linked immunosorbent assay (ELISA) and malondialdehyde level was measured by the colorimetric method.
Results
Livin/BIRC7
gene expression was significantly (
p
< 0.001) higher in endometrial carcinoma from patients with endometrial hyperplasia when compared to controls. A positive correlation was found between
livin/BIRC7
expression and serum catalase activity and malondialdehyde level in endometrial hyperplasia and carcinoma. The detection of
livin/BIRC7
in endometrial carcinoma has excellent sensitivity and specificity.
Conclusions
Livin/BIRC7
was overexpressed in endometrial carcinoma with excellent power to differentiate endometrial carcinoma from endometrial hyperplasia or healthy subjects, suggesting that it might be a useful molecular marker for endometrial carcinoma diagnosis.</description><subject>Age</subject><subject>Analysis</subject><subject>Apoptosis</subject><subject>Biomarkers</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>BIRC7</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Carcinoma</subject><subject>Catalase</subject><subject>Cell cycle</subject><subject>Colorimetry</subject><subject>Development and progression</subject><subject>Diagnostic systems</subject><subject>DNA polymerases</subject><subject>Endometrial cancer</subject><subject>Endometrial carcinoma</subject><subject>Endometrial hyperplasia</subject><subject>Endometrium</subject><subject>Engineering</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Enzymes</subject><subject>Estrogens</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Gynecology</subject><subject>Hyperplasia</subject><subject>IAP protein</subject><subject>Livin</subject><subject>Malondialdehyde</subject><subject>Medical prognosis</subject><subject>Menopause</subject><subject>Obstetrics</subject><subject>Oxidative stress</subject><subject>Polymerase chain reaction</subject><subject>Prevention</subject><subject>Proteins</subject><subject>RNA-directed DNA polymerase</subject><subject>Signal transduction</subject><subject>Uterine cancer</subject><issn>1687-157X</issn><issn>2090-5920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNp9kl1rFDEUhgdR7FL7B7yQgNfT5muSzI1Ql6oLCwVR8C4kMyezWWeTMdlt7b83261tF8R8EJLznodzyFtVbwk-J0SJi8wZ4aTGtGxMOa9vX1QziltcNy3FL6sZEUrWpJE_TqqznNe4jIYr0pDX1QnjjVCtYrNqtfQ3Plx8XHydSzRAAAS_pwQ5-xiQycigKZaLHQH13gwh5q3vkPVxY9JPSMjFhCD0cQPb5M2IVncTpGk02RtkQo86kzofivpN9cqZMcPZw3laff909W3-pV5ef17ML5d1J7Dc1sQqK5UCTnthhcS95a2jpCyhKMaiocTS1rkeM2MJFZYoDFI2ynGlXNey02px4PbRrPWUfCn0Tkfj9f1DTIM2qfQwgu4FpY0ljlECXBhhsAIiWma5pMo0e9aHA2va2Q30HYRtMuMR9DgS_EoP8UYrLlnDcAG8fwCk-GsHeavXcZdC6V9TRSjjrAifVIMpVfngYoF1G587fSlk2zDZtnvW-T9UZfaw8V0M4Hx5P0qgh4QulS9M4B4LJ1jvPaQPHtLFQ_reQ_q2JL173vJjyl_HFAE7CHIJhQHSU0v_wf4BYgfQ-w</recordid><startdate>20210926</startdate><enddate>20210926</enddate><creator>Elmekkawy, Basma K.</creator><creator>Shoaib, Rasha M. S.</creator><creator>Seleem, Amal K.</creator><creator>Shaalan, Dalia</creator><creator>Saad, Entsar A.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><general>Elsevier</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>L6V</scope><scope>LK8</scope><scope>M7P</scope><scope>M7S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6477-8098</orcidid></search><sort><creationdate>20210926</creationdate><title>Livin/BIRC7 gene expression as a possible diagnostic biomarker for endometrial hyperplasia and carcinoma</title><author>Elmekkawy, Basma K. ; Shoaib, Rasha M. S. ; Seleem, Amal K. ; Shaalan, Dalia ; Saad, Entsar A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c607t-1b8b788e42d6b670db49f21f21682006521b29ffd03ab126b180e7758f488fc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>Analysis</topic><topic>Apoptosis</topic><topic>Biomarkers</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>BIRC7</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Carcinoma</topic><topic>Catalase</topic><topic>Cell cycle</topic><topic>Colorimetry</topic><topic>Development and progression</topic><topic>Diagnostic systems</topic><topic>DNA polymerases</topic><topic>Endometrial cancer</topic><topic>Endometrial carcinoma</topic><topic>Endometrial hyperplasia</topic><topic>Endometrium</topic><topic>Engineering</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Enzymes</topic><topic>Estrogens</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Gynecology</topic><topic>Hyperplasia</topic><topic>IAP protein</topic><topic>Livin</topic><topic>Malondialdehyde</topic><topic>Medical prognosis</topic><topic>Menopause</topic><topic>Obstetrics</topic><topic>Oxidative stress</topic><topic>Polymerase chain reaction</topic><topic>Prevention</topic><topic>Proteins</topic><topic>RNA-directed DNA polymerase</topic><topic>Signal transduction</topic><topic>Uterine cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elmekkawy, Basma K.</creatorcontrib><creatorcontrib>Shoaib, Rasha M. S.</creatorcontrib><creatorcontrib>Seleem, Amal K.</creatorcontrib><creatorcontrib>Shaalan, Dalia</creatorcontrib><creatorcontrib>Saad, Entsar A.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of Genetic Engineering and Biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elmekkawy, Basma K.</au><au>Shoaib, Rasha M. S.</au><au>Seleem, Amal K.</au><au>Shaalan, Dalia</au><au>Saad, Entsar A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Livin/BIRC7 gene expression as a possible diagnostic biomarker for endometrial hyperplasia and carcinoma</atitle><jtitle>Journal of Genetic Engineering and Biotechnology</jtitle><stitle>J Genet Eng Biotechnol</stitle><addtitle>J Genet Eng Biotechnol</addtitle><date>2021-09-26</date><risdate>2021</risdate><volume>19</volume><issue>1</issue><spage>141</spage><epage>8</epage><pages>141-8</pages><artnum>141</artnum><issn>1687-157X</issn><eissn>2090-5920</eissn><abstract>Background
Livin/BIRC7
is a member of the inhibitors of apoptosis proteins family which are implicated in development of cancer through the inhibition of apoptosis process. This case-control study was intended to investigate
livin/BIRC7
gene expression in endometrial hyperplasia and carcinoma and its correlation to some oxidative stress markers in addition to its possible diagnostic performance.
Methods
This study included 90 participants [30 endometrial hyperplasia patients, 30 endometrial carcinoma patients, and 30 healthy controls].
Livin/BIRC7
gene expression was analyzed using quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). Serum catalase activity was assessed by enzyme-linked immunosorbent assay (ELISA) and malondialdehyde level was measured by the colorimetric method.
Results
Livin/BIRC7
gene expression was significantly (
p
< 0.001) higher in endometrial carcinoma from patients with endometrial hyperplasia when compared to controls. A positive correlation was found between
livin/BIRC7
expression and serum catalase activity and malondialdehyde level in endometrial hyperplasia and carcinoma. The detection of
livin/BIRC7
in endometrial carcinoma has excellent sensitivity and specificity.
Conclusions
Livin/BIRC7
was overexpressed in endometrial carcinoma with excellent power to differentiate endometrial carcinoma from endometrial hyperplasia or healthy subjects, suggesting that it might be a useful molecular marker for endometrial carcinoma diagnosis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34568983</pmid><doi>10.1186/s43141-021-00244-w</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-6477-8098</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1687-157X |
| ispartof | Journal of Genetic Engineering and Biotechnology, 2021-09, Vol.19 (1), p.141-8, Article 141 |
| issn | 1687-157X 2090-5920 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8473530 |
| source | DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Age Analysis Apoptosis Biomarkers Biomedical Engineering and Bioengineering BIRC7 Cancer Cancer therapies Carcinoma Catalase Cell cycle Colorimetry Development and progression Diagnostic systems DNA polymerases Endometrial cancer Endometrial carcinoma Endometrial hyperplasia Endometrium Engineering Enzyme-linked immunosorbent assay Enzymes Estrogens Gene expression Genes Genetic aspects Gynecology Hyperplasia IAP protein Livin Malondialdehyde Medical prognosis Menopause Obstetrics Oxidative stress Polymerase chain reaction Prevention Proteins RNA-directed DNA polymerase Signal transduction Uterine cancer |
| title | Livin/BIRC7 gene expression as a possible diagnostic biomarker for endometrial hyperplasia and carcinoma |
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