Proteomics: Concepts and applications in human medicine

Proteomics: Concepts and applications in human medicine

Proteomics is the complete evaluation of the function and structure of proteins to understand an organism’s nature. Mass spectrometry is an essential tool that is used for profiling proteins in the cell. However, biomarker discovery remains the major challenge of proteomics because of their complexi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:World journal of biological chemistry 2021-09, Vol.12 (5), p.57-69
Hauptverfasser: Al-Amrani, Safa, Al-Jabri, Zaaima, Al-Zaabi, Adhari, Alshekaili, Jalila, Al-Khabori, Murtadha
Format: Artikel
Sprache:eng
Schlagworte:
Review
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 69
container_issue 5
container_start_page 57
container_title World journal of biological chemistry
container_volume 12
creator Al-Amrani, Safa
Al-Jabri, Zaaima
Al-Zaabi, Adhari
Alshekaili, Jalila
Al-Khabori, Murtadha
description Proteomics is the complete evaluation of the function and structure of proteins to understand an organism’s nature. Mass spectrometry is an essential tool that is used for profiling proteins in the cell. However, biomarker discovery remains the major challenge of proteomics because of their complexity and dynamicity. Therefore, combining the proteomics approach with genomics and bioinformatics will provide an understanding of the information of biological systems and their disease alteration. However, most studies have investigated a small part of the proteins in the blood. This review highlights the types of proteomics, the available proteomic techniques, and their applications in different research fields.
doi_str_mv 10.4331/wjbc.v12.i5.57
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8473418</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2580946031</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2577-6c6290a4dc6109c33a5ac3b63aae58d1a56ac3316cf016d6e737fb0fb291888e3</originalsourceid><addsrcrecordid>eNpVkM1Lw0AQxRdRbKm9es7RS-Ju9jMeBCl-QUEPel4mm43dkuzGbFLxvzelRXQuM495vAc_hC4Jzhil5PprW5psR_LM8YzLEzQnBStSxTg7_XPP0DLGLZ6GcSGoPEczygTFBcFzJF_7MNjQOhNvklXwxnZDTMBXCXRd4wwMLviYOJ9sxhZ80trKGeftBTqroYl2edwL9P5w_7Z6Stcvj8-ru3Vqci5lKozICwysMoLgwlAKHAwtBQWwXFUEuJg0JcLUmIhKWEllXeK6zAuilLJ0gW4Pud1YTt3G-qGHRne9a6H_1gGc_v_xbqM_wk4rJikjagq4Ogb04XO0cdCti8Y2DXgbxqhzrnDBBKZksmYHq-lDjL2tf2sI1nvgeg9cT8C145pL-gNMTHPu</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2580946031</pqid></control><display><type>article</type><title>Proteomics: Concepts and applications in human medicine</title><source>Baishideng "World Journal of" online journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Al-Amrani, Safa ; Al-Jabri, Zaaima ; Al-Zaabi, Adhari ; Alshekaili, Jalila ; Al-Khabori, Murtadha</creator><creatorcontrib>Al-Amrani, Safa ; Al-Jabri, Zaaima ; Al-Zaabi, Adhari ; Alshekaili, Jalila ; Al-Khabori, Murtadha</creatorcontrib><description>Proteomics is the complete evaluation of the function and structure of proteins to understand an organism’s nature. Mass spectrometry is an essential tool that is used for profiling proteins in the cell. However, biomarker discovery remains the major challenge of proteomics because of their complexity and dynamicity. Therefore, combining the proteomics approach with genomics and bioinformatics will provide an understanding of the information of biological systems and their disease alteration. However, most studies have investigated a small part of the proteins in the blood. This review highlights the types of proteomics, the available proteomic techniques, and their applications in different research fields.</description><identifier>ISSN: 1949-8454</identifier><identifier>EISSN: 1949-8454</identifier><identifier>DOI: 10.4331/wjbc.v12.i5.57</identifier><identifier>PMID: 34630910</identifier><language>eng</language><publisher>Baishideng Publishing Group Inc</publisher><subject>Review</subject><ispartof>World journal of biological chemistry, 2021-09, Vol.12 (5), p.57-69</ispartof><rights>The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. 2021</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2577-6c6290a4dc6109c33a5ac3b63aae58d1a56ac3316cf016d6e737fb0fb291888e3</citedby><cites>FETCH-LOGICAL-c2577-6c6290a4dc6109c33a5ac3b63aae58d1a56ac3316cf016d6e737fb0fb291888e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473418/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473418/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids></links><search><creatorcontrib>Al-Amrani, Safa</creatorcontrib><creatorcontrib>Al-Jabri, Zaaima</creatorcontrib><creatorcontrib>Al-Zaabi, Adhari</creatorcontrib><creatorcontrib>Alshekaili, Jalila</creatorcontrib><creatorcontrib>Al-Khabori, Murtadha</creatorcontrib><title>Proteomics: Concepts and applications in human medicine</title><title>World journal of biological chemistry</title><description>Proteomics is the complete evaluation of the function and structure of proteins to understand an organism’s nature. Mass spectrometry is an essential tool that is used for profiling proteins in the cell. However, biomarker discovery remains the major challenge of proteomics because of their complexity and dynamicity. Therefore, combining the proteomics approach with genomics and bioinformatics will provide an understanding of the information of biological systems and their disease alteration. However, most studies have investigated a small part of the proteins in the blood. This review highlights the types of proteomics, the available proteomic techniques, and their applications in different research fields.</description><subject>Review</subject><issn>1949-8454</issn><issn>1949-8454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpVkM1Lw0AQxRdRbKm9es7RS-Ju9jMeBCl-QUEPel4mm43dkuzGbFLxvzelRXQuM495vAc_hC4Jzhil5PprW5psR_LM8YzLEzQnBStSxTg7_XPP0DLGLZ6GcSGoPEczygTFBcFzJF_7MNjQOhNvklXwxnZDTMBXCXRd4wwMLviYOJ9sxhZ80trKGeftBTqroYl2edwL9P5w_7Z6Stcvj8-ru3Vqci5lKozICwysMoLgwlAKHAwtBQWwXFUEuJg0JcLUmIhKWEllXeK6zAuilLJ0gW4Pud1YTt3G-qGHRne9a6H_1gGc_v_xbqM_wk4rJikjagq4Ogb04XO0cdCti8Y2DXgbxqhzrnDBBKZksmYHq-lDjL2tf2sI1nvgeg9cT8C145pL-gNMTHPu</recordid><startdate>20210927</startdate><enddate>20210927</enddate><creator>Al-Amrani, Safa</creator><creator>Al-Jabri, Zaaima</creator><creator>Al-Zaabi, Adhari</creator><creator>Alshekaili, Jalila</creator><creator>Al-Khabori, Murtadha</creator><general>Baishideng Publishing Group Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210927</creationdate><title>Proteomics: Concepts and applications in human medicine</title><author>Al-Amrani, Safa ; Al-Jabri, Zaaima ; Al-Zaabi, Adhari ; Alshekaili, Jalila ; Al-Khabori, Murtadha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2577-6c6290a4dc6109c33a5ac3b63aae58d1a56ac3316cf016d6e737fb0fb291888e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Review</topic><toplevel>online_resources</toplevel><creatorcontrib>Al-Amrani, Safa</creatorcontrib><creatorcontrib>Al-Jabri, Zaaima</creatorcontrib><creatorcontrib>Al-Zaabi, Adhari</creatorcontrib><creatorcontrib>Alshekaili, Jalila</creatorcontrib><creatorcontrib>Al-Khabori, Murtadha</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al-Amrani, Safa</au><au>Al-Jabri, Zaaima</au><au>Al-Zaabi, Adhari</au><au>Alshekaili, Jalila</au><au>Al-Khabori, Murtadha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proteomics: Concepts and applications in human medicine</atitle><jtitle>World journal of biological chemistry</jtitle><date>2021-09-27</date><risdate>2021</risdate><volume>12</volume><issue>5</issue><spage>57</spage><epage>69</epage><pages>57-69</pages><issn>1949-8454</issn><eissn>1949-8454</eissn><abstract>Proteomics is the complete evaluation of the function and structure of proteins to understand an organism’s nature. Mass spectrometry is an essential tool that is used for profiling proteins in the cell. However, biomarker discovery remains the major challenge of proteomics because of their complexity and dynamicity. Therefore, combining the proteomics approach with genomics and bioinformatics will provide an understanding of the information of biological systems and their disease alteration. However, most studies have investigated a small part of the proteins in the blood. This review highlights the types of proteomics, the available proteomic techniques, and their applications in different research fields.</abstract><pub>Baishideng Publishing Group Inc</pub><pmid>34630910</pmid><doi>10.4331/wjbc.v12.i5.57</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1949-8454
ispartof World journal of biological chemistry, 2021-09, Vol.12 (5), p.57-69
issn 1949-8454
1949-8454
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8473418
source Baishideng "World Journal of" online journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central
subjects Review
title Proteomics: Concepts and applications in human medicine
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T19%3A32%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Proteomics:%20Concepts%20and%20applications%20in%20human%20medicine&rft.jtitle=World%20journal%20of%20biological%20chemistry&rft.au=Al-Amrani,%20Safa&rft.date=2021-09-27&rft.volume=12&rft.issue=5&rft.spage=57&rft.epage=69&rft.pages=57-69&rft.issn=1949-8454&rft.eissn=1949-8454&rft_id=info:doi/10.4331/wjbc.v12.i5.57&rft_dat=%3Cproquest_pubme%3E2580946031%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2580946031&rft_id=info:pmid/34630910&rfr_iscdi=true