The Role of Cancer-Associated Fibroblasts in Cancer Invasion and Metastasis

Cancer-associated fibroblasts (CAFs) play a key role in cancer progression by contributing to extracellular matrix (ECM) deposition and remodeling, extensive crosstalk with cancer cells, epithelial-to-mesenchymal transition (EMT), invasion, metastasis, and therapy resistance. As metastasis is a main...

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Veröffentlicht in:	Cancers 2021-09, Vol.13 (18), p.4720
Hauptverfasser:	Asif, Paris Jabeen, Longobardi, Ciro, Hahne, Michael, Medema, Jan Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Cancer Cell growth Collagen Colorectal carcinoma Cytokines Enzymes Extracellular matrix Fibroblasts Growth factors Lethality Medical prognosis Mesenchyme Metastases Metastasis Physiology Review Stroma Tumor cells
Online-Zugang:	Volltext
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