The Role of Cancer-Associated Fibroblasts in Cancer Invasion and Metastasis
Cancer-associated fibroblasts (CAFs) play a key role in cancer progression by contributing to extracellular matrix (ECM) deposition and remodeling, extensive crosstalk with cancer cells, epithelial-to-mesenchymal transition (EMT), invasion, metastasis, and therapy resistance. As metastasis is a main...
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| Veröffentlicht in: | Cancers 2021-09, Vol.13 (18), p.4720 |
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| creator | Asif, Paris Jabeen Longobardi, Ciro Hahne, Michael Medema, Jan Paul |
| description | Cancer-associated fibroblasts (CAFs) play a key role in cancer progression by contributing to extracellular matrix (ECM) deposition and remodeling, extensive crosstalk with cancer cells, epithelial-to-mesenchymal transition (EMT), invasion, metastasis, and therapy resistance. As metastasis is a main reason for cancer-related deaths, it is crucial to understand the role of CAFs in this process. Colorectal cancer (CRC) is a heterogeneous disease and lethality is especially common in a subtype of CRC with high stromal infiltration. A key component of stroma is cancer-associated fibroblasts (CAFs). To provide new perspectives for research on CAFs and CAF-targeted therapeutics, especially in CRC, we discuss the mechanisms, crosstalk, and functions involved in CAF-mediated cancer invasion, metastasis, and protection. This summary can serve as a framework for future studies elucidating these roles of CAFs. |
| doi_str_mv | 10.3390/cancers13184720 |
| format | Article |
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| subjects | Breast cancer Cancer Cell growth Cellular Biology Collagen Colorectal carcinoma Cytokines Enzymes Extracellular matrix Fibroblasts Growth factors Lethality Life Sciences Medical prognosis Mesenchyme Metastases Metastasis Physiology Review Stroma Tumor cells |
| title | The Role of Cancer-Associated Fibroblasts in Cancer Invasion and Metastasis |
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