Age-Associated Increase in Thrombogenicity and Its Correlation with von Willebrand Factor
Endothelial cells that cover the lumen of all blood vessels have the inherent capacity to express both pro and anticoagulant molecules. However, under normal physiological condition, they generally function to maintain a non-thrombogenic surface for unobstructed blood flow. In response to injury, ce...
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| Veröffentlicht in: | Journal of clinical medicine 2021-09, Vol.10 (18), p.4190 |
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| creator | Alavi, Parnian Rathod, Abhisha M. Jahroudi, Nadia |
| description | Endothelial cells that cover the lumen of all blood vessels have the inherent capacity to express both pro and anticoagulant molecules. However, under normal physiological condition, they generally function to maintain a non-thrombogenic surface for unobstructed blood flow. In response to injury, certain stimuli, or as a result of dysfunction, endothelial cells release a highly adhesive procoagulant protein, von Willebrand factor (VWF), which plays a central role in formation of platelet aggregates and thrombus generation. Since VWF expression is highly restricted to endothelial cells, regulation of its levels is among the most important functions of endothelial cells for maintaining hemostasis. However, with aging, there is a significant increase in VWF levels, which is concomitant with a significant rise in thrombotic events. It is not yet clear why and how aging results in increased VWF levels. In this review, we have aimed to discuss the age-related increase in VWF, its potential mechanisms, and associated coagulopathies as probable consequences. |
| doi_str_mv | 10.3390/jcm10184190 |
| format | Article |
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However, under normal physiological condition, they generally function to maintain a non-thrombogenic surface for unobstructed blood flow. In response to injury, certain stimuli, or as a result of dysfunction, endothelial cells release a highly adhesive procoagulant protein, von Willebrand factor (VWF), which plays a central role in formation of platelet aggregates and thrombus generation. Since VWF expression is highly restricted to endothelial cells, regulation of its levels is among the most important functions of endothelial cells for maintaining hemostasis. However, with aging, there is a significant increase in VWF levels, which is concomitant with a significant rise in thrombotic events. It is not yet clear why and how aging results in increased VWF levels. In this review, we have aimed to discuss the age-related increase in VWF, its potential mechanisms, and associated coagulopathies as probable consequences.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm10184190</identifier><identifier>PMID: 34575297</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Age ; Aging ; Anticoagulants ; Binding sites ; Biosynthesis ; Blood clots ; Blood groups ; Blood platelets ; Clinical medicine ; Enzymes ; Extracellular matrix ; Heart attacks ; Older people ; Physiology ; Plasma ; Population ; Proteins ; Review ; Risk factors ; Thromboembolism ; Thrombosis</subject><ispartof>Journal of clinical medicine, 2021-09, Vol.10 (18), p.4190</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. 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However, under normal physiological condition, they generally function to maintain a non-thrombogenic surface for unobstructed blood flow. In response to injury, certain stimuli, or as a result of dysfunction, endothelial cells release a highly adhesive procoagulant protein, von Willebrand factor (VWF), which plays a central role in formation of platelet aggregates and thrombus generation. Since VWF expression is highly restricted to endothelial cells, regulation of its levels is among the most important functions of endothelial cells for maintaining hemostasis. However, with aging, there is a significant increase in VWF levels, which is concomitant with a significant rise in thrombotic events. It is not yet clear why and how aging results in increased VWF levels. 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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Age Aging Anticoagulants Binding sites Biosynthesis Blood clots Blood groups Blood platelets Clinical medicine Enzymes Extracellular matrix Heart attacks Older people Physiology Plasma Population Proteins Review Risk factors Thromboembolism Thrombosis |
| title | Age-Associated Increase in Thrombogenicity and Its Correlation with von Willebrand Factor |
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