Partially Hydrolysed Whey-Based Infant Formula Improves Skin Barrier Function
Specific partially hydrolysed whey-based infant formulas (pHF-W) have been shown to decrease the risk of atopic dermatitis (AD) in infants. Historically, AD has been associated primarily with milk allergy; however, defective skin barrier function can be a primary cause of AD. We aimed to ascertain w...
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| Veröffentlicht in: | Nutrients 2021-09, Vol.13 (9), p.3113 |
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| creator | Holvoet, Sébastien Nutten, Sophie Dupuis, Lénaïck Donnicola, Dominique Bourdeau, Tristan Hughes-Formella, Betsy Simon, Dagmar Simon, Hans-Uwe Carvalho, Ryan S. Spergel, Jonathan M. Koletzko, Sibylle Blanchard, Carine |
| description | Specific partially hydrolysed whey-based infant formulas (pHF-W) have been shown to decrease the risk of atopic dermatitis (AD) in infants. Historically, AD has been associated primarily with milk allergy; however, defective skin barrier function can be a primary cause of AD. We aimed to ascertain whether oral supplementation with pHF-W can improve skin barrier function. The effect of pHF-W was assessed on transepidermal water loss (TEWL) and antibody productions in mice epicutaneously exposed to Aspergillus fumigatus. Human primary keratinocytes were stimulated in vitro, and the expression of genes related to skin barrier function was measured. Supplementation with pHF-W in neonatal mice led to a significant decrease in TEWL and total IgE, but not in allergen-specific antibody levels. The whey hydrolysate was sufficient to decrease both TEWL and total IgE. Aquaporin-3 gene expression, linked with skin hydration, was modulated in the skin of mice and human primary keratinocytes following protein hydrolysate exposure. Skin barrier improvement may be an additional mechanism by which pHF-W may potentially reduce the risk of AD development in infants. Further human studies are warranted to confirm the clinical efficacy of these observations. |
| doi_str_mv | 10.3390/nu13093113 |
| format | Article |
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Historically, AD has been associated primarily with milk allergy; however, defective skin barrier function can be a primary cause of AD. We aimed to ascertain whether oral supplementation with pHF-W can improve skin barrier function. The effect of pHF-W was assessed on transepidermal water loss (TEWL) and antibody productions in mice epicutaneously exposed to Aspergillus fumigatus. Human primary keratinocytes were stimulated in vitro, and the expression of genes related to skin barrier function was measured. Supplementation with pHF-W in neonatal mice led to a significant decrease in TEWL and total IgE, but not in allergen-specific antibody levels. The whey hydrolysate was sufficient to decrease both TEWL and total IgE. Aquaporin-3 gene expression, linked with skin hydration, was modulated in the skin of mice and human primary keratinocytes following protein hydrolysate exposure. Skin barrier improvement may be an additional mechanism by which pHF-W may potentially reduce the risk of AD development in infants. Further human studies are warranted to confirm the clinical efficacy of these observations.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu13093113</identifier><identifier>PMID: 34578990</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Allergens ; Aquaporins ; Atopic dermatitis ; Babies ; Baby foods ; Dermatitis ; Disease ; Eczema ; Food allergies ; Gene expression ; Hydration ; Hydrolysates ; Hypersensitivity ; Hypotheses ; Immunoglobulin E ; Infant formulas ; Infants ; Keratinocytes ; Lipids ; Milk ; Mutation ; Neonates ; Proteins ; Risk factors ; Risk reduction ; Skin ; Whey</subject><ispartof>Nutrients, 2021-09, Vol.13 (9), p.3113</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-63344e834b47abca7c2f141edf8b15f83626cae06b0043660599237e34abae013</citedby><cites>FETCH-LOGICAL-c383t-63344e834b47abca7c2f141edf8b15f83626cae06b0043660599237e34abae013</cites><orcidid>0000-0003-0481-9286 ; 0000-0002-9404-7736</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472312/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472312/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Holvoet, Sébastien</creatorcontrib><creatorcontrib>Nutten, Sophie</creatorcontrib><creatorcontrib>Dupuis, Lénaïck</creatorcontrib><creatorcontrib>Donnicola, Dominique</creatorcontrib><creatorcontrib>Bourdeau, Tristan</creatorcontrib><creatorcontrib>Hughes-Formella, Betsy</creatorcontrib><creatorcontrib>Simon, Dagmar</creatorcontrib><creatorcontrib>Simon, Hans-Uwe</creatorcontrib><creatorcontrib>Carvalho, Ryan S.</creatorcontrib><creatorcontrib>Spergel, Jonathan M.</creatorcontrib><creatorcontrib>Koletzko, Sibylle</creatorcontrib><creatorcontrib>Blanchard, Carine</creatorcontrib><title>Partially Hydrolysed Whey-Based Infant Formula Improves Skin Barrier Function</title><title>Nutrients</title><description>Specific partially hydrolysed whey-based infant formulas (pHF-W) have been shown to decrease the risk of atopic dermatitis (AD) in infants. Historically, AD has been associated primarily with milk allergy; however, defective skin barrier function can be a primary cause of AD. We aimed to ascertain whether oral supplementation with pHF-W can improve skin barrier function. The effect of pHF-W was assessed on transepidermal water loss (TEWL) and antibody productions in mice epicutaneously exposed to Aspergillus fumigatus. Human primary keratinocytes were stimulated in vitro, and the expression of genes related to skin barrier function was measured. Supplementation with pHF-W in neonatal mice led to a significant decrease in TEWL and total IgE, but not in allergen-specific antibody levels. The whey hydrolysate was sufficient to decrease both TEWL and total IgE. Aquaporin-3 gene expression, linked with skin hydration, was modulated in the skin of mice and human primary keratinocytes following protein hydrolysate exposure. Skin barrier improvement may be an additional mechanism by which pHF-W may potentially reduce the risk of AD development in infants. Further human studies are warranted to confirm the clinical efficacy of these observations.</description><subject>Allergens</subject><subject>Aquaporins</subject><subject>Atopic dermatitis</subject><subject>Babies</subject><subject>Baby foods</subject><subject>Dermatitis</subject><subject>Disease</subject><subject>Eczema</subject><subject>Food allergies</subject><subject>Gene expression</subject><subject>Hydration</subject><subject>Hydrolysates</subject><subject>Hypersensitivity</subject><subject>Hypotheses</subject><subject>Immunoglobulin E</subject><subject>Infant formulas</subject><subject>Infants</subject><subject>Keratinocytes</subject><subject>Lipids</subject><subject>Milk</subject><subject>Mutation</subject><subject>Neonates</subject><subject>Proteins</subject><subject>Risk factors</subject><subject>Risk reduction</subject><subject>Skin</subject><subject>Whey</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkd9LwzAQx4MoTuZe_AsKvohQTXJp0r4Ibjg3mCio-BjSLnWdbTKTdtD_3pYNf93LHXcfvtzdF6Ezgq8AEnxtGgI4AULgAJ1QLGjIOYPDX_UAjbxf4z4EFhyO0QBYJOIkwSfo4Um5ulBl2Qazduls2Xq9DN5Wug3Hqi_nJlemDqbWVU2pgnm1cXarffD8UZhgrJwrtAumjcnqwppTdJSr0uvRPg_R6_TuZTILF4_388ntIswghjrkAIzpGFjKhEozJTKaE0b0Mo9TEuUxcMozpTFPMWbAOY6ShILQwFTatQkM0c1Od9OklV5m2tROlXLjikq5VlpVyL8TU6zku93KmAkKhHYCF3sBZz8b7WtZFT7TZamMto2XNBKCRYRHSYee_0PXtnGmO6-nOOs-CrijLndU5qz3TuffyxAse6Pkj1HwBcVkg3A</recordid><startdate>20210904</startdate><enddate>20210904</enddate><creator>Holvoet, Sébastien</creator><creator>Nutten, Sophie</creator><creator>Dupuis, Lénaïck</creator><creator>Donnicola, Dominique</creator><creator>Bourdeau, Tristan</creator><creator>Hughes-Formella, Betsy</creator><creator>Simon, Dagmar</creator><creator>Simon, Hans-Uwe</creator><creator>Carvalho, Ryan S.</creator><creator>Spergel, Jonathan M.</creator><creator>Koletzko, Sibylle</creator><creator>Blanchard, Carine</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0481-9286</orcidid><orcidid>https://orcid.org/0000-0002-9404-7736</orcidid></search><sort><creationdate>20210904</creationdate><title>Partially Hydrolysed Whey-Based Infant Formula Improves Skin Barrier Function</title><author>Holvoet, Sébastien ; 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Historically, AD has been associated primarily with milk allergy; however, defective skin barrier function can be a primary cause of AD. We aimed to ascertain whether oral supplementation with pHF-W can improve skin barrier function. The effect of pHF-W was assessed on transepidermal water loss (TEWL) and antibody productions in mice epicutaneously exposed to Aspergillus fumigatus. Human primary keratinocytes were stimulated in vitro, and the expression of genes related to skin barrier function was measured. Supplementation with pHF-W in neonatal mice led to a significant decrease in TEWL and total IgE, but not in allergen-specific antibody levels. The whey hydrolysate was sufficient to decrease both TEWL and total IgE. Aquaporin-3 gene expression, linked with skin hydration, was modulated in the skin of mice and human primary keratinocytes following protein hydrolysate exposure. Skin barrier improvement may be an additional mechanism by which pHF-W may potentially reduce the risk of AD development in infants. Further human studies are warranted to confirm the clinical efficacy of these observations.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>34578990</pmid><doi>10.3390/nu13093113</doi><orcidid>https://orcid.org/0000-0003-0481-9286</orcidid><orcidid>https://orcid.org/0000-0002-9404-7736</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Allergens Aquaporins Atopic dermatitis Babies Baby foods Dermatitis Disease Eczema Food allergies Gene expression Hydration Hydrolysates Hypersensitivity Hypotheses Immunoglobulin E Infant formulas Infants Keratinocytes Lipids Milk Mutation Neonates Proteins Risk factors Risk reduction Skin Whey |
| title | Partially Hydrolysed Whey-Based Infant Formula Improves Skin Barrier Function |
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