Current Challenges in Deciphering Sutton Nevi—Literature Review and Personal Experience
Halo nevi, known as leukoderma acquisitum centrifugum, Sutton nevus, leukopigmentary nevus, perinevoid vitiligo, or perinevoid leukoderma, together with vitiligo and melanoma-associated hypopigmentation, belong to the group of dermatoses designated as immunological leukodermas. The etiology and path...
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| Veröffentlicht in: | Journal of personalized medicine 2021-09, Vol.11 (9), p.904 |
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| creator | Nedelcu, Roxana Dobre, Alexandra Brinzea, Alice Hulea, Ionela Andrei, Razvan Zurac, Sabina Balaban, Mihaela Antohe, Mihaela Manea, Lorena Calinescu, Andreea Coman, Anastasia Pantelimon, Florentina Dobritoiu, Adina Popescu, Catalin Popescu, Raluca Balasescu, Elena Ion, Daniela Turcu, Gabriela |
| description | Halo nevi, known as leukoderma acquisitum centrifugum, Sutton nevus, leukopigmentary nevus, perinevoid vitiligo, or perinevoid leukoderma, together with vitiligo and melanoma-associated hypopigmentation, belong to the group of dermatoses designated as immunological leukodermas. The etiology and pathogenesis of halo nevi has not been fully elucidated. There are several mechanisms through which a lymphocytic infiltrate can induce tumoral regression. In this review, we aimed to update the knowledge about Sutton nevi starting with the clinical appearance and dermoscopic features, continuing with information regarding conventional microscopy, immunohistochemistry, and the immunological mechanisms responsible for the occurrence of halo nevi. We also included in the article original unpublished results when discussing dermoscopic, pathologic and immunohistochemical results in halo nevi. Sutton nevi are valuable models for studying antitumor reactions that the human body can generate. The slow and effective mechanism against a melanocytic skin tumor can teach us important lessons about both autoimmune diseases and anticancer defenses. |
| doi_str_mv | 10.3390/jpm11090904 |
| format | Article |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Autoimmune diseases Etiology Immunohistochemistry Leukoderma Literature reviews Melanoma Nevus Patients Pigmentation Precision medicine Review Vitiligo |
| title | Current Challenges in Deciphering Sutton Nevi—Literature Review and Personal Experience |
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