RANTES 59029A/G Polymorphisms Associated with Diabetic Compilations in Korean Patients with Type 2 Diabetes for over 15 Years
Polymorphisms in the RANTES gene are known to be associated with several diseases related to insulin resistance. In this study, we investigated the association between RANTES 59029A/G polymorphisms and the prevalence of diabetic complications relative to obesity in Korean patients who had type 2 dia...
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| Veröffentlicht in: | Genes 2021-09, Vol.12 (9), p.1445 |
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| description | Polymorphisms in the RANTES gene are known to be associated with several diseases related to insulin resistance. In this study, we investigated the association between RANTES 59029A/G polymorphisms and the prevalence of diabetic complications relative to obesity in Korean patients who had type 2 diabetes (T2D) for over 15 years.
A single-center, retrospective case-control study was performed. We included 271 patients with a duration of diabetes greater than 15 years. Polymerase chain reaction-restriction fragment length polymorphism was used to analyze RANTES polymorphisms, identifying genotypes as GG, AG, or AA. Obesity was defined using the body mass index with a cutoff value of 25 kg/m
. Both microvascular (retinopathy and nephropathy) and macrovascular (coronary artery disease and cerebrovascular disease) complications were evaluated.
The duration of T2D and hemoglobin A1c values at enrollment were 24.4 ± 5.0 years and 7.8 ± 1.6%, respectively, in the non-obese group, and 25.4 ± 6.1 years and 7.7 ± 1.7%, respectively, in the obese group. The prevalence of microvascular complications was significantly higher in the obese group compared with that in the non-obese group (83.5% vs. 72.0%,
= 0.039). Compared to the non-obese group, the obese group showed a higher proportion of the patients with AA or AG genotypes (64.3% vs. 84.5%,
= 0.001).
The A allele of the RANTES gene is associated with obesity and may affect diabetic microvascular complications in patients with T2D for over 15 years. |
| doi_str_mv | 10.3390/genes12091445 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8468929</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2577460398</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-7910a96f270a72a696ce58f38f8af6ee7f6750f6ac91c5864343315326fe3d9a3</originalsourceid><addsrcrecordid>eNpdkU1PGzEQhq2qCBBw5FpZ4tLLFn97fUGKUqBVEaA2PfRkGWdMjHbXW3sDyqH_vRslIGAuM5p55tWMXoSOKfnCuSGn99BBoYwYKoT8gPYZ0bwSgsmPr-o9dFTKAxlDEEaI3EV7XEjNBdP76N_PyfXs_BeWhjAzOb3Et6lZtSn3i1jagielJB_dAHP8FIcF_hrdHQzR42lq-9i4Iaau4NjhHymD6_Dt2IFuKBt6tuoBs-0SFBxSxukRMqYS_wGXyyHaCa4pcLTNB-j3xfls-q26urn8Pp1cVV5QOVTaUOKMCkwTp5lTRnmQdeB1qF1QADooLUlQzhvqZa0EF5xTyZkKwOfG8QN0ttHtl3ctzP14YnaN7XNsXV7Z5KJ9O-niwt6nR1sLVRtmRoHPW4Gc_i6hDLaNxUPTuA7SslgmtRaKcFOP6Mk79CEtcze-t6aUoLSWa8FqQ_mcSskQXo6hxK69tW-8HflPrz94oZ-d5P8Bs0WeyA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2576411859</pqid></control><display><type>article</type><title>RANTES 59029A/G Polymorphisms Associated with Diabetic Compilations in Korean Patients with Type 2 Diabetes for over 15 Years</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Lee, Dong-Hwa ; Ku, Eu-Jeong ; Oh, Tae-Keun ; Jeon, Hyun-Jeong</creator><creatorcontrib>Lee, Dong-Hwa ; Ku, Eu-Jeong ; Oh, Tae-Keun ; Jeon, Hyun-Jeong</creatorcontrib><description>Polymorphisms in the RANTES gene are known to be associated with several diseases related to insulin resistance. In this study, we investigated the association between RANTES 59029A/G polymorphisms and the prevalence of diabetic complications relative to obesity in Korean patients who had type 2 diabetes (T2D) for over 15 years.
A single-center, retrospective case-control study was performed. We included 271 patients with a duration of diabetes greater than 15 years. Polymerase chain reaction-restriction fragment length polymorphism was used to analyze RANTES polymorphisms, identifying genotypes as GG, AG, or AA. Obesity was defined using the body mass index with a cutoff value of 25 kg/m
. Both microvascular (retinopathy and nephropathy) and macrovascular (coronary artery disease and cerebrovascular disease) complications were evaluated.
The duration of T2D and hemoglobin A1c values at enrollment were 24.4 ± 5.0 years and 7.8 ± 1.6%, respectively, in the non-obese group, and 25.4 ± 6.1 years and 7.7 ± 1.7%, respectively, in the obese group. The prevalence of microvascular complications was significantly higher in the obese group compared with that in the non-obese group (83.5% vs. 72.0%,
= 0.039). Compared to the non-obese group, the obese group showed a higher proportion of the patients with AA or AG genotypes (64.3% vs. 84.5%,
= 0.001).
The A allele of the RANTES gene is associated with obesity and may affect diabetic microvascular complications in patients with T2D for over 15 years.</description><identifier>ISSN: 2073-4425</identifier><identifier>EISSN: 2073-4425</identifier><identifier>DOI: 10.3390/genes12091445</identifier><identifier>PMID: 34573427</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adults ; Aged ; Angina pectoris ; Asians - genetics ; Body Mass Index ; Cardiovascular disease ; Case-Control Studies ; Cerebrovascular diseases ; Chemokine CCL5 - genetics ; Coronary artery ; Coronary vessels ; Diabetes ; Diabetes Complications - genetics ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - genetics ; Female ; Gene polymorphism ; Genotype & phenotype ; Heart diseases ; Hemoglobin ; Humans ; Insulin ; Insulin resistance ; Male ; Medical records ; Metabolism ; Microvasculature ; Middle Aged ; Nephropathy ; Obesity ; Obesity - genetics ; Patients ; Polymerase chain reaction ; Polymorphism ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Population ; RANTES ; Restriction fragment length polymorphism ; Retinopathy ; Retrospective Studies</subject><ispartof>Genes, 2021-09, Vol.12 (9), p.1445</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-7910a96f270a72a696ce58f38f8af6ee7f6750f6ac91c5864343315326fe3d9a3</citedby><cites>FETCH-LOGICAL-c415t-7910a96f270a72a696ce58f38f8af6ee7f6750f6ac91c5864343315326fe3d9a3</cites><orcidid>0000-0002-1552-3205</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468929/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468929/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34573427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Dong-Hwa</creatorcontrib><creatorcontrib>Ku, Eu-Jeong</creatorcontrib><creatorcontrib>Oh, Tae-Keun</creatorcontrib><creatorcontrib>Jeon, Hyun-Jeong</creatorcontrib><title>RANTES 59029A/G Polymorphisms Associated with Diabetic Compilations in Korean Patients with Type 2 Diabetes for over 15 Years</title><title>Genes</title><addtitle>Genes (Basel)</addtitle><description>Polymorphisms in the RANTES gene are known to be associated with several diseases related to insulin resistance. In this study, we investigated the association between RANTES 59029A/G polymorphisms and the prevalence of diabetic complications relative to obesity in Korean patients who had type 2 diabetes (T2D) for over 15 years.
A single-center, retrospective case-control study was performed. We included 271 patients with a duration of diabetes greater than 15 years. Polymerase chain reaction-restriction fragment length polymorphism was used to analyze RANTES polymorphisms, identifying genotypes as GG, AG, or AA. Obesity was defined using the body mass index with a cutoff value of 25 kg/m
. Both microvascular (retinopathy and nephropathy) and macrovascular (coronary artery disease and cerebrovascular disease) complications were evaluated.
The duration of T2D and hemoglobin A1c values at enrollment were 24.4 ± 5.0 years and 7.8 ± 1.6%, respectively, in the non-obese group, and 25.4 ± 6.1 years and 7.7 ± 1.7%, respectively, in the obese group. The prevalence of microvascular complications was significantly higher in the obese group compared with that in the non-obese group (83.5% vs. 72.0%,
= 0.039). Compared to the non-obese group, the obese group showed a higher proportion of the patients with AA or AG genotypes (64.3% vs. 84.5%,
= 0.001).
The A allele of the RANTES gene is associated with obesity and may affect diabetic microvascular complications in patients with T2D for over 15 years.</description><subject>Adults</subject><subject>Aged</subject><subject>Angina pectoris</subject><subject>Asians - genetics</subject><subject>Body Mass Index</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Cerebrovascular diseases</subject><subject>Chemokine CCL5 - genetics</subject><subject>Coronary artery</subject><subject>Coronary vessels</subject><subject>Diabetes</subject><subject>Diabetes Complications - genetics</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Genotype & phenotype</subject><subject>Heart diseases</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Male</subject><subject>Medical records</subject><subject>Metabolism</subject><subject>Microvasculature</subject><subject>Middle Aged</subject><subject>Nephropathy</subject><subject>Obesity</subject><subject>Obesity - genetics</subject><subject>Patients</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Population</subject><subject>RANTES</subject><subject>Restriction fragment length polymorphism</subject><subject>Retinopathy</subject><subject>Retrospective Studies</subject><issn>2073-4425</issn><issn>2073-4425</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkU1PGzEQhq2qCBBw5FpZ4tLLFn97fUGKUqBVEaA2PfRkGWdMjHbXW3sDyqH_vRslIGAuM5p55tWMXoSOKfnCuSGn99BBoYwYKoT8gPYZ0bwSgsmPr-o9dFTKAxlDEEaI3EV7XEjNBdP76N_PyfXs_BeWhjAzOb3Et6lZtSn3i1jagielJB_dAHP8FIcF_hrdHQzR42lq-9i4Iaau4NjhHymD6_Dt2IFuKBt6tuoBs-0SFBxSxukRMqYS_wGXyyHaCa4pcLTNB-j3xfls-q26urn8Pp1cVV5QOVTaUOKMCkwTp5lTRnmQdeB1qF1QADooLUlQzhvqZa0EF5xTyZkKwOfG8QN0ttHtl3ctzP14YnaN7XNsXV7Z5KJ9O-niwt6nR1sLVRtmRoHPW4Gc_i6hDLaNxUPTuA7SslgmtRaKcFOP6Mk79CEtcze-t6aUoLSWa8FqQ_mcSskQXo6hxK69tW-8HflPrz94oZ-d5P8Bs0WeyA</recordid><startdate>20210919</startdate><enddate>20210919</enddate><creator>Lee, Dong-Hwa</creator><creator>Ku, Eu-Jeong</creator><creator>Oh, Tae-Keun</creator><creator>Jeon, Hyun-Jeong</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1552-3205</orcidid></search><sort><creationdate>20210919</creationdate><title>RANTES 59029A/G Polymorphisms Associated with Diabetic Compilations in Korean Patients with Type 2 Diabetes for over 15 Years</title><author>Lee, Dong-Hwa ; Ku, Eu-Jeong ; Oh, Tae-Keun ; Jeon, Hyun-Jeong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-7910a96f270a72a696ce58f38f8af6ee7f6750f6ac91c5864343315326fe3d9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adults</topic><topic>Aged</topic><topic>Angina pectoris</topic><topic>Asians - genetics</topic><topic>Body Mass Index</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>Cerebrovascular diseases</topic><topic>Chemokine CCL5 - genetics</topic><topic>Coronary artery</topic><topic>Coronary vessels</topic><topic>Diabetes</topic><topic>Diabetes Complications - genetics</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>Genotype & phenotype</topic><topic>Heart diseases</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Male</topic><topic>Medical records</topic><topic>Metabolism</topic><topic>Microvasculature</topic><topic>Middle Aged</topic><topic>Nephropathy</topic><topic>Obesity</topic><topic>Obesity - genetics</topic><topic>Patients</topic><topic>Polymerase chain reaction</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Population</topic><topic>RANTES</topic><topic>Restriction fragment length polymorphism</topic><topic>Retinopathy</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Dong-Hwa</creatorcontrib><creatorcontrib>Ku, Eu-Jeong</creatorcontrib><creatorcontrib>Oh, Tae-Keun</creatorcontrib><creatorcontrib>Jeon, Hyun-Jeong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Dong-Hwa</au><au>Ku, Eu-Jeong</au><au>Oh, Tae-Keun</au><au>Jeon, Hyun-Jeong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RANTES 59029A/G Polymorphisms Associated with Diabetic Compilations in Korean Patients with Type 2 Diabetes for over 15 Years</atitle><jtitle>Genes</jtitle><addtitle>Genes (Basel)</addtitle><date>2021-09-19</date><risdate>2021</risdate><volume>12</volume><issue>9</issue><spage>1445</spage><pages>1445-</pages><issn>2073-4425</issn><eissn>2073-4425</eissn><abstract>Polymorphisms in the RANTES gene are known to be associated with several diseases related to insulin resistance. In this study, we investigated the association between RANTES 59029A/G polymorphisms and the prevalence of diabetic complications relative to obesity in Korean patients who had type 2 diabetes (T2D) for over 15 years.
A single-center, retrospective case-control study was performed. We included 271 patients with a duration of diabetes greater than 15 years. Polymerase chain reaction-restriction fragment length polymorphism was used to analyze RANTES polymorphisms, identifying genotypes as GG, AG, or AA. Obesity was defined using the body mass index with a cutoff value of 25 kg/m
. Both microvascular (retinopathy and nephropathy) and macrovascular (coronary artery disease and cerebrovascular disease) complications were evaluated.
The duration of T2D and hemoglobin A1c values at enrollment were 24.4 ± 5.0 years and 7.8 ± 1.6%, respectively, in the non-obese group, and 25.4 ± 6.1 years and 7.7 ± 1.7%, respectively, in the obese group. The prevalence of microvascular complications was significantly higher in the obese group compared with that in the non-obese group (83.5% vs. 72.0%,
= 0.039). Compared to the non-obese group, the obese group showed a higher proportion of the patients with AA or AG genotypes (64.3% vs. 84.5%,
= 0.001).
The A allele of the RANTES gene is associated with obesity and may affect diabetic microvascular complications in patients with T2D for over 15 years.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>34573427</pmid><doi>10.3390/genes12091445</doi><orcidid>https://orcid.org/0000-0002-1552-3205</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Adults Aged Angina pectoris Asians - genetics Body Mass Index Cardiovascular disease Case-Control Studies Cerebrovascular diseases Chemokine CCL5 - genetics Coronary artery Coronary vessels Diabetes Diabetes Complications - genetics Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - genetics Female Gene polymorphism Genotype & phenotype Heart diseases Hemoglobin Humans Insulin Insulin resistance Male Medical records Metabolism Microvasculature Middle Aged Nephropathy Obesity Obesity - genetics Patients Polymerase chain reaction Polymorphism Polymorphism, Genetic Polymorphism, Restriction Fragment Length Population RANTES Restriction fragment length polymorphism Retinopathy Retrospective Studies |
| title | RANTES 59029A/G Polymorphisms Associated with Diabetic Compilations in Korean Patients with Type 2 Diabetes for over 15 Years |
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