Plant Viral Nanoparticle Conjugated with Anti-PD-1 Peptide for Ovarian Cancer Immunotherapy

Immunotherapy holds tremendous potential in cancer therapy, in particular, when treatment regimens are combined to achieve synergy between pathways along the cancer immunity cycle. In previous works, we demonstrated that in situ vaccination with the plant virus cowpea mosaic virus (CPMV) activates a...

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Veröffentlicht in:	International journal of molecular sciences 2021-09, Vol.22 (18), p.9733
Hauptverfasser:	Gautam, Aayushma, Beiss, Veronique, Wang, Chao, Wang, Lu, Steinmetz, Nicole F
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animal models Animals Antigens Apoptosis B7-H1 Antigen - antagonists & inhibitors Cancer immunotherapy Cancer Vaccines - administration & dosage Cancer Vaccines - immunology Communication Comovirus Cowpeas Disease Models, Animal Effector cells Female Humans Immune checkpoint Immune system Immunotherapy In vivo methods and tests Lymphocytes Lymphocytes T Mammals Melanoma Metastases Metastasis Mice Microenvironments Molecular weight Nanoparticles Neutrophils Ovarian cancer Ovarian Neoplasms - immunology Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy PD-1 protein PD-L1 protein Peptides Peptides - chemistry Peptides - immunology Plant Viruses Proteins Tumor microenvironment Tumors Vaccination Vaccines Vaccines, Virus-Like Particle - administration & dosage Vaccines, Virus-Like Particle - immunology Viruses Xenograft Model Antitumor Assays
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