The Short-Chain Fatty Acid Butyrate Attenuates Pulmonary Vascular Remodeling and Inflammation in Hypoxia-Induced Pulmonary Hypertension

Pulmonary hypertension (PH) is a progressive cardiovascular disorder in which local vascular inflammation leads to increased pulmonary vascular remodeling and ultimately to right heart failure. The HDAC inhibitor butyrate, a product of microbial fermentation, is protective in inflammatory intestinal...

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Veröffentlicht in:	International journal of molecular sciences 2021-09, Vol.22 (18), p.9916
Hauptverfasser:	Karoor, Vijaya, Strassheim, Derek, Sullivan, Timothy, Verin, Alexander, Umapathy, Nagavedi S, Dempsey, Edward C, Frank, Daniel N, Stenmark, Kurt R, Gerasimovskaya, Evgenia
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acetylation - drug effects Alveoli Angiogenesis Animals Blood pressure Blood Pressure - drug effects Butyrates - pharmacology Cardiovascular diseases CD163 antigen Cell cycle Congestive heart failure Cytokines Cytokines - metabolism Disease Endothelial cells Endothelial Cells - drug effects Epigenetics Fatty acids Fermentation Fibroblasts Fractalkine Gene expression Heart Ventricles - drug effects Heart Ventricles - physiopathology Histone deacetylase Histone H3 Histones Hypertension Hypertension, Pulmonary - etiology Hypertension, Pulmonary - physiopathology Hypertrophy Hypertrophy, Right Ventricular - complications Hypertrophy, Right Ventricular - physiopathology Hypoxia Hypoxia - complications Inflammation Lipopolysaccharides Lung - blood supply Lung - drug effects Lung - physiopathology Lungs Lysates Macrophages Macrophages - drug effects Macrophages - pathology Metabolism Metabolites Microbiota Microorganisms Microvasculature Microvessels - pathology Pathogenesis Permeability Pneumonia - complications Pneumonia - physiopathology Proteins Pulmonary hypertension Rats Rats, Sprague-Dawley Systole - drug effects Systolic pressure Tight Junctions - drug effects Tight Junctions - metabolism Tissue inhibitor of metalloproteinase 1 Tubulin Tumor necrosis factor-α Up-Regulation - drug effects Vascular Remodeling - drug effects Ventricle
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