Associations between Postprandial Gut Hormones and Markers of Bone Remodeling
Gut-derived hormones have been suggested to play a role in bone homeostasis following food intake, although the associations are highly complex and not fully understood. In a randomized, two-day cross-over study on 14 healthy individuals, we performed postprandial time-course studies to examine the...
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Veröffentlicht in: | Nutrients 2021-09, Vol.13 (9), p.3197 |
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description | Gut-derived hormones have been suggested to play a role in bone homeostasis following food intake, although the associations are highly complex and not fully understood. In a randomized, two-day cross-over study on 14 healthy individuals, we performed postprandial time-course studies to examine the associations of the bone remodeling markers carboxyl-terminal collagen type I crosslinks (CTX) and procollagen type 1 N-terminal propeptide (P1NP) with the gut hormones glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1), and peptide YY (PYY) using two different meal types—a standardized mixed meal (498 kcal) or a granola bar (260 kcal). Plasma concentrations of total GIP, total GLP-1, total PYY, CTX, and P1NP were measured up to 240 min after meal intake, and the incremental area under the curve (iAUC) for each marker was calculated. The iAUC of CTX and P1NP were used to assess associations with the iAUC of GIP, GLP-1, and PYY in linear mixed effect models adjusted for meal type. CTX was positively associated with GIP and GLP-1, and it was inversely associated with PYY (all p < 0.001). No associations of P1NP with GIP or GLP-1 and PYY were found. In conclusion, the postprandial responses of the gut hormones GIP, GLP-1, and PYY are associated with the bone resorption marker CTX, supporting a link between gut hormones and bone homeostasis following food intake. |
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In a randomized, two-day cross-over study on 14 healthy individuals, we performed postprandial time-course studies to examine the associations of the bone remodeling markers carboxyl-terminal collagen type I crosslinks (CTX) and procollagen type 1 N-terminal propeptide (P1NP) with the gut hormones glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1), and peptide YY (PYY) using two different meal types—a standardized mixed meal (498 kcal) or a granola bar (260 kcal). Plasma concentrations of total GIP, total GLP-1, total PYY, CTX, and P1NP were measured up to 240 min after meal intake, and the incremental area under the curve (iAUC) for each marker was calculated. The iAUC of CTX and P1NP were used to assess associations with the iAUC of GIP, GLP-1, and PYY in linear mixed effect models adjusted for meal type. CTX was positively associated with GIP and GLP-1, and it was inversely associated with PYY (all p < 0.001). No associations of P1NP with GIP or GLP-1 and PYY were found. In conclusion, the postprandial responses of the gut hormones GIP, GLP-1, and PYY are associated with the bone resorption marker CTX, supporting a link between gut hormones and bone homeostasis following food intake.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu13093197</identifier><identifier>PMID: 34579074</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Biomarkers ; Body mass index ; Bone remodeling ; Bone resorption ; Bone turnover ; Bones ; Collagen (type I) ; Diabetes ; Food intake ; Gastrointestinal surgery ; GIP protein ; Glucagon ; Glucagon-like peptide 1 ; Homeostasis ; Hormones ; Immunoassay ; Markers ; Meals ; Metabolism ; Peptides ; Plasma ; Polypeptides ; Procollagen ; Substance abuse treatment</subject><ispartof>Nutrients, 2021-09, Vol.13 (9), p.3197</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-1d37762467e6deb4423a23361e8aa913f39aebe4b8de56793d0d85ea32edbbae3</citedby><cites>FETCH-LOGICAL-c383t-1d37762467e6deb4423a23361e8aa913f39aebe4b8de56793d0d85ea32edbbae3</cites><orcidid>0000-0002-4530-1945 ; 0000-0001-6036-0962 ; 0000-0001-7913-7373 ; 0000-0003-2660-3240 ; 0000-0002-6127-0448</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467604/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467604/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids></links><search><creatorcontrib>Jensen, Nina</creatorcontrib><creatorcontrib>Clemmensen, Kim</creatorcontrib><creatorcontrib>Jensen, Marie</creatorcontrib><creatorcontrib>Pedersen, Hanne</creatorcontrib><creatorcontrib>Færch, Kristine</creatorcontrib><creatorcontrib>Diaz, Lars</creatorcontrib><creatorcontrib>Quist, Jonas</creatorcontrib><creatorcontrib>Størling, Joachim</creatorcontrib><title>Associations between Postprandial Gut Hormones and Markers of Bone Remodeling</title><title>Nutrients</title><description>Gut-derived hormones have been suggested to play a role in bone homeostasis following food intake, although the associations are highly complex and not fully understood. In a randomized, two-day cross-over study on 14 healthy individuals, we performed postprandial time-course studies to examine the associations of the bone remodeling markers carboxyl-terminal collagen type I crosslinks (CTX) and procollagen type 1 N-terminal propeptide (P1NP) with the gut hormones glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1), and peptide YY (PYY) using two different meal types—a standardized mixed meal (498 kcal) or a granola bar (260 kcal). Plasma concentrations of total GIP, total GLP-1, total PYY, CTX, and P1NP were measured up to 240 min after meal intake, and the incremental area under the curve (iAUC) for each marker was calculated. The iAUC of CTX and P1NP were used to assess associations with the iAUC of GIP, GLP-1, and PYY in linear mixed effect models adjusted for meal type. CTX was positively associated with GIP and GLP-1, and it was inversely associated with PYY (all p < 0.001). No associations of P1NP with GIP or GLP-1 and PYY were found. In conclusion, the postprandial responses of the gut hormones GIP, GLP-1, and PYY are associated with the bone resorption marker CTX, supporting a link between gut hormones and bone homeostasis following food intake.</description><subject>Biomarkers</subject><subject>Body mass index</subject><subject>Bone remodeling</subject><subject>Bone resorption</subject><subject>Bone turnover</subject><subject>Bones</subject><subject>Collagen (type I)</subject><subject>Diabetes</subject><subject>Food intake</subject><subject>Gastrointestinal surgery</subject><subject>GIP protein</subject><subject>Glucagon</subject><subject>Glucagon-like peptide 1</subject><subject>Homeostasis</subject><subject>Hormones</subject><subject>Immunoassay</subject><subject>Markers</subject><subject>Meals</subject><subject>Metabolism</subject><subject>Peptides</subject><subject>Plasma</subject><subject>Polypeptides</subject><subject>Procollagen</subject><subject>Substance abuse treatment</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkd9LwzAQx4Mobsy9-BcEfBGhmvaypH0R5tBNcCiizyFtbrOzTWbSKv73dmz4617u-N6H791xhBzH7BwgYxe2jYFlEGdyj_QTJpNICA77v-oeGYawYpuQTAo4JD3gI5kxyftkPg7BFaVuSmcDzbH5QLT0wYVm7bU1pa7otG3ozPnaWQy00-hc-1f0gboFvepE-oi1M1iVdnlEDha6Cjjc5QF5vrl-msyiu_vp7WR8FxWQQhPFBqQUCRcShcGc8wR0AiBiTLXOYlhApjFHnqcGR0JmYJhJR6ghQZPnGmFALre-6zav0RRoG68rtfZlrf2ncrpUfzu2fFFL967SbqZgvDM43Rl499ZiaFRdhgKrSlt0bVDJSErOZcrSDj35h65c62133oYSHSSTuKPOtlThXQgeF9_LxExtHqV-HgVfznCEtQ</recordid><startdate>20210914</startdate><enddate>20210914</enddate><creator>Jensen, Nina</creator><creator>Clemmensen, Kim</creator><creator>Jensen, Marie</creator><creator>Pedersen, Hanne</creator><creator>Færch, Kristine</creator><creator>Diaz, Lars</creator><creator>Quist, Jonas</creator><creator>Størling, Joachim</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4530-1945</orcidid><orcidid>https://orcid.org/0000-0001-6036-0962</orcidid><orcidid>https://orcid.org/0000-0001-7913-7373</orcidid><orcidid>https://orcid.org/0000-0003-2660-3240</orcidid><orcidid>https://orcid.org/0000-0002-6127-0448</orcidid></search><sort><creationdate>20210914</creationdate><title>Associations between Postprandial Gut Hormones and Markers of Bone Remodeling</title><author>Jensen, Nina ; Clemmensen, Kim ; Jensen, Marie ; Pedersen, Hanne ; Færch, Kristine ; Diaz, Lars ; Quist, Jonas ; Størling, Joachim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-1d37762467e6deb4423a23361e8aa913f39aebe4b8de56793d0d85ea32edbbae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biomarkers</topic><topic>Body mass index</topic><topic>Bone remodeling</topic><topic>Bone resorption</topic><topic>Bone turnover</topic><topic>Bones</topic><topic>Collagen (type I)</topic><topic>Diabetes</topic><topic>Food intake</topic><topic>Gastrointestinal surgery</topic><topic>GIP protein</topic><topic>Glucagon</topic><topic>Glucagon-like peptide 1</topic><topic>Homeostasis</topic><topic>Hormones</topic><topic>Immunoassay</topic><topic>Markers</topic><topic>Meals</topic><topic>Metabolism</topic><topic>Peptides</topic><topic>Plasma</topic><topic>Polypeptides</topic><topic>Procollagen</topic><topic>Substance abuse treatment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jensen, Nina</creatorcontrib><creatorcontrib>Clemmensen, Kim</creatorcontrib><creatorcontrib>Jensen, Marie</creatorcontrib><creatorcontrib>Pedersen, Hanne</creatorcontrib><creatorcontrib>Færch, Kristine</creatorcontrib><creatorcontrib>Diaz, Lars</creatorcontrib><creatorcontrib>Quist, Jonas</creatorcontrib><creatorcontrib>Størling, Joachim</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jensen, Nina</au><au>Clemmensen, Kim</au><au>Jensen, Marie</au><au>Pedersen, Hanne</au><au>Færch, Kristine</au><au>Diaz, Lars</au><au>Quist, Jonas</au><au>Størling, Joachim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations between Postprandial Gut Hormones and Markers of Bone Remodeling</atitle><jtitle>Nutrients</jtitle><date>2021-09-14</date><risdate>2021</risdate><volume>13</volume><issue>9</issue><spage>3197</spage><pages>3197-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Gut-derived hormones have been suggested to play a role in bone homeostasis following food intake, although the associations are highly complex and not fully understood. In a randomized, two-day cross-over study on 14 healthy individuals, we performed postprandial time-course studies to examine the associations of the bone remodeling markers carboxyl-terminal collagen type I crosslinks (CTX) and procollagen type 1 N-terminal propeptide (P1NP) with the gut hormones glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1), and peptide YY (PYY) using two different meal types—a standardized mixed meal (498 kcal) or a granola bar (260 kcal). Plasma concentrations of total GIP, total GLP-1, total PYY, CTX, and P1NP were measured up to 240 min after meal intake, and the incremental area under the curve (iAUC) for each marker was calculated. The iAUC of CTX and P1NP were used to assess associations with the iAUC of GIP, GLP-1, and PYY in linear mixed effect models adjusted for meal type. CTX was positively associated with GIP and GLP-1, and it was inversely associated with PYY (all p < 0.001). No associations of P1NP with GIP or GLP-1 and PYY were found. In conclusion, the postprandial responses of the gut hormones GIP, GLP-1, and PYY are associated with the bone resorption marker CTX, supporting a link between gut hormones and bone homeostasis following food intake.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>34579074</pmid><doi>10.3390/nu13093197</doi><orcidid>https://orcid.org/0000-0002-4530-1945</orcidid><orcidid>https://orcid.org/0000-0001-6036-0962</orcidid><orcidid>https://orcid.org/0000-0001-7913-7373</orcidid><orcidid>https://orcid.org/0000-0003-2660-3240</orcidid><orcidid>https://orcid.org/0000-0002-6127-0448</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Biomarkers Body mass index Bone remodeling Bone resorption Bone turnover Bones Collagen (type I) Diabetes Food intake Gastrointestinal surgery GIP protein Glucagon Glucagon-like peptide 1 Homeostasis Hormones Immunoassay Markers Meals Metabolism Peptides Plasma Polypeptides Procollagen Substance abuse treatment |
title | Associations between Postprandial Gut Hormones and Markers of Bone Remodeling |
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