Associations between Postprandial Gut Hormones and Markers of Bone Remodeling

Gut-derived hormones have been suggested to play a role in bone homeostasis following food intake, although the associations are highly complex and not fully understood. In a randomized, two-day cross-over study on 14 healthy individuals, we performed postprandial time-course studies to examine the...

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Veröffentlicht in:Nutrients 2021-09, Vol.13 (9), p.3197
Hauptverfasser: Jensen, Nina, Clemmensen, Kim, Jensen, Marie, Pedersen, Hanne, Færch, Kristine, Diaz, Lars, Quist, Jonas, Størling, Joachim
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container_end_page
container_issue 9
container_start_page 3197
container_title Nutrients
container_volume 13
creator Jensen, Nina
Clemmensen, Kim
Jensen, Marie
Pedersen, Hanne
Færch, Kristine
Diaz, Lars
Quist, Jonas
Størling, Joachim
description Gut-derived hormones have been suggested to play a role in bone homeostasis following food intake, although the associations are highly complex and not fully understood. In a randomized, two-day cross-over study on 14 healthy individuals, we performed postprandial time-course studies to examine the associations of the bone remodeling markers carboxyl-terminal collagen type I crosslinks (CTX) and procollagen type 1 N-terminal propeptide (P1NP) with the gut hormones glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1), and peptide YY (PYY) using two different meal types—a standardized mixed meal (498 kcal) or a granola bar (260 kcal). Plasma concentrations of total GIP, total GLP-1, total PYY, CTX, and P1NP were measured up to 240 min after meal intake, and the incremental area under the curve (iAUC) for each marker was calculated. The iAUC of CTX and P1NP were used to assess associations with the iAUC of GIP, GLP-1, and PYY in linear mixed effect models adjusted for meal type. CTX was positively associated with GIP and GLP-1, and it was inversely associated with PYY (all p < 0.001). No associations of P1NP with GIP or GLP-1 and PYY were found. In conclusion, the postprandial responses of the gut hormones GIP, GLP-1, and PYY are associated with the bone resorption marker CTX, supporting a link between gut hormones and bone homeostasis following food intake.
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source PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects Biomarkers
Body mass index
Bone remodeling
Bone resorption
Bone turnover
Bones
Collagen (type I)
Diabetes
Food intake
Gastrointestinal surgery
GIP protein
Glucagon
Glucagon-like peptide 1
Homeostasis
Hormones
Immunoassay
Markers
Meals
Metabolism
Peptides
Plasma
Polypeptides
Procollagen
Substance abuse treatment
title Associations between Postprandial Gut Hormones and Markers of Bone Remodeling
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