Interleukins 4 and 13 drive lipid abnormalities in skin cells through regulation of sex steroid hormone synthesis

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin dryness, inflammation, and itch. A major hallmark of AD is an elevation of the immune cytokines IL-4 and IL-13. These cytokines lead to skin barrier disruption and lipid abnormalities in AD, yet the underlying mechan...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-09, Vol.118 (38), p.1-10
Hauptverfasser:	Zhang, Chenlu, Chinnappan, Mahendran, Prestwood, Courtney A., Edwards, Marshall, Artami, Methinee, Thompson, Bonne M., Eckert, Kaitlyn M., Vale, Goncalo, Zouboulis, Christos C., McDonald, Jeffrey G., Harris-Tryon, Tamia A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Androgens Animals Antibodies, Monoclonal, Humanized - pharmacology Antiinfectives and antibacterials Atopic dermatitis Biological Sciences Cell Line Cytokines Cytokines - metabolism Dermatitis Dermatitis, Atopic - metabolism Disease Models, Animal Epithelial cells Epithelium Gonadal Steroid Hormones - metabolism HaCaT Cells Humans Hydroxysteroids Inflammation - drug therapy Inflammation - metabolism Interleukin 13 Interleukin 4 Interleukin-13 - metabolism Interleukin-4 - metabolism Keratinocytes Keratinocytes - drug effects Keratinocytes - metabolism Lipids Male Mice Mice, Inbred BALB C Monoclonal antibodies Patients Sebaceous gland Sebaceous glands Sebaceous Glands - drug effects Sebaceous Glands - metabolism Sex Skin - drug effects Skin - metabolism Skin diseases Skin Diseases - drug therapy Skin Diseases - metabolism Steroids Synthesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!