Mitochondria-Rich Extracellular Vesicles Rescue Patient-Specific Cardiomyocytes From Doxorubicin Injury: Insights Into the SENECA Trial

Anthracycline-induced cardiomyopathy (AIC) is a significant source of morbidity and mortality in cancer survivors. The role of mesenchymal stem cells (MSCs) in treating AIC was evaluated in the SENECA trial, a Phase 1 National Heart, Lung, and Blood Institute-sponsored study, but the mechanisms unde...

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Veröffentlicht in:JACC CardioOncology 2021-09, Vol.3 (3), p.428-440
Hauptverfasser: O'Brien, Connor G, Ozen, Mehmet Ozgun, Ikeda, Gentaro, Vaskova, Evgeniya, Jung, Ji Hye, Bayardo, Nathan, Santoso, Michelle Rai, Shi, Liye, Wahlquist, Christine, Jiang, Zewen, Jung, Yunshin, Zeng, Yitian, Egan, Elizabeth, Sinclair, Robert, Gee, Adrian, Witteles, Ronald, Mercola, Mark, Svensson, Katrin J, Demirci, Utkan, Yang, Phillip C
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Sprache:eng
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