Low endogenous testosterone levels are associated with the extend of lymphnodal invasion at radical prostatectomy and extended pelvic lymph node dissection

Objective To investigate clinical factors associated to lymphnodal metastasis load in patients who underwent to radical prostatectomy (RP) and extended pelvic lymph node dissection (ePLND). Materials and methods Between November 2014 and December 2019, ET was measured in 617 consecutive patients not...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:International urology and nephrology 2021-10, Vol.53 (10), p.2027-2039
Hauptverfasser: Porcaro, Antonio Benito, Cerrato, Clara, Tafuri, Alessandro, Bianchi, Alberto, Gallina, Sebastian, Orlando, Rossella, Amigoni, Nelia, Rizzetto, Riccardo, Gozzo, Alessandra, Migliorini, Filippo, Zecchini Antoniolli, Stefano, Monaco, Carmelo, Brunelli, Matteo, Cerruto, Maria Angela, Antonelli, Alessandro
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 2039
container_issue 10
container_start_page 2027
container_title International urology and nephrology
container_volume 53
creator Porcaro, Antonio Benito
Cerrato, Clara
Tafuri, Alessandro
Bianchi, Alberto
Gallina, Sebastian
Orlando, Rossella
Amigoni, Nelia
Rizzetto, Riccardo
Gozzo, Alessandra
Migliorini, Filippo
Zecchini Antoniolli, Stefano
Monaco, Carmelo
Brunelli, Matteo
Cerruto, Maria Angela
Antonelli, Alessandro
description Objective To investigate clinical factors associated to lymphnodal metastasis load in patients who underwent to radical prostatectomy (RP) and extended pelvic lymph node dissection (ePLND). Materials and methods Between November 2014 and December 2019, ET was measured in 617 consecutive patients not under androgen deprivation therapy who underwent RP and ePLND. Lymphnode invasion (LNI) was codified as not present ( N  = 0) or with one ( N  = 1) or more than one metastatic node ( N  > 1). The risk of multiple pelvic lymph node metastasis ( N  > 1, mPLNM) was assessed by comparing it to the other two groups ( N  > 1 vs. N  = 0 and N  > 1 vs. N  = 1). Then, we assessed the association between ET and lymphnode invasion for standard predictors, such as PSA, percentage of biopsy positive cores (BPC), tumor stage greater than 1 (cT > 1) and tumor grade group greater than two (ISUP > 2). Results Overall, LNI was detected in 70 patients (11.3%) of whom 39 (6.3%) with N  = 1 and 31 (5%) with N  > 1. On multivariate analysis, ET was inversely associated with the risk of N  > 1 when compared to both N  = 0 (odds ratio, OR 0.997; CI 0.994–1; p  = 0.027) as well as with N  = 1 cases (OR 0.994; 95% CI 0.989–1.000; p  = 0.015). Conclusions In clinical PCa, the risk of mPLNM was increased by low ET levels. As ET decreased, patients had an increased likelihood of mPLNM. Because of the inverse association between ET and mPLNM, higher ET levels were protective against aggressive disease. The influence of locally advanced PCa with high metastatic load on ET levels needs to be explored by controlled trials.
doi_str_mv 10.1007/s11255-021-02938-z
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8463355</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2548907373</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-83127c6b6794e19c09e2b9911ef3b1a555d0f13c15705cbdf7090c485b9404ec3</originalsourceid><addsrcrecordid>eNp9kUtv1DAUhSMEokPhD7BAltiwCfiZxBskVPGSRmIDa8txbmZcJXawPdNO_wp_lgsp5bFgYVnyPeezfU5VPWX0JaO0fZUZ40rVlDNcWnT1zb1qw1Qraq46eb_aUEFZzRouzqpHOV9SSnVH6cPqTEjOO97QTfVtG68IhCHuIMRDJgVyiblAigHIBEeYMrEJiM05Om8LDOTKlz0peyBwXdBJ4kim07zsQxzsRHw42uxjILaQZAfv8GxJiESvK3E-EYue1YqwBaajdyuAIAHI4HNGJSIeVw9GO2V4crufV1_evf188aHefnr_8eLNtnaylaXuBOOta_qm1RKYdlQD77VmDEbRM6uUGujIhMNkqHL9MLZUUyc71WtJJThxXr1eucuhn2FwEEqyk1mSn206mWi9-XsS_N7s4tF0shFCKQS8uAWk-PWACZrZZwfTZANgqIYr2Wnailag9Pk_0st4SAG_h6q2YZJpzlDFV5XD5HKC8e4xjJof3Zu1e4Pdm5_dmxs0PfvzG3eWX2WjQKyCjKOwg_T77v9gvwPFcL80</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2576141921</pqid></control><display><type>article</type><title>Low endogenous testosterone levels are associated with the extend of lymphnodal invasion at radical prostatectomy and extended pelvic lymph node dissection</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Porcaro, Antonio Benito ; Cerrato, Clara ; Tafuri, Alessandro ; Bianchi, Alberto ; Gallina, Sebastian ; Orlando, Rossella ; Amigoni, Nelia ; Rizzetto, Riccardo ; Gozzo, Alessandra ; Migliorini, Filippo ; Zecchini Antoniolli, Stefano ; Monaco, Carmelo ; Brunelli, Matteo ; Cerruto, Maria Angela ; Antonelli, Alessandro</creator><creatorcontrib>Porcaro, Antonio Benito ; Cerrato, Clara ; Tafuri, Alessandro ; Bianchi, Alberto ; Gallina, Sebastian ; Orlando, Rossella ; Amigoni, Nelia ; Rizzetto, Riccardo ; Gozzo, Alessandra ; Migliorini, Filippo ; Zecchini Antoniolli, Stefano ; Monaco, Carmelo ; Brunelli, Matteo ; Cerruto, Maria Angela ; Antonelli, Alessandro</creatorcontrib><description>Objective To investigate clinical factors associated to lymphnodal metastasis load in patients who underwent to radical prostatectomy (RP) and extended pelvic lymph node dissection (ePLND). Materials and methods Between November 2014 and December 2019, ET was measured in 617 consecutive patients not under androgen deprivation therapy who underwent RP and ePLND. Lymphnode invasion (LNI) was codified as not present ( N  = 0) or with one ( N  = 1) or more than one metastatic node ( N  &gt; 1). The risk of multiple pelvic lymph node metastasis ( N  &gt; 1, mPLNM) was assessed by comparing it to the other two groups ( N  &gt; 1 vs. N  = 0 and N  &gt; 1 vs. N  = 1). Then, we assessed the association between ET and lymphnode invasion for standard predictors, such as PSA, percentage of biopsy positive cores (BPC), tumor stage greater than 1 (cT &gt; 1) and tumor grade group greater than two (ISUP &gt; 2). Results Overall, LNI was detected in 70 patients (11.3%) of whom 39 (6.3%) with N  = 1 and 31 (5%) with N  &gt; 1. On multivariate analysis, ET was inversely associated with the risk of N  &gt; 1 when compared to both N  = 0 (odds ratio, OR 0.997; CI 0.994–1; p  = 0.027) as well as with N  = 1 cases (OR 0.994; 95% CI 0.989–1.000; p  = 0.015). Conclusions In clinical PCa, the risk of mPLNM was increased by low ET levels. As ET decreased, patients had an increased likelihood of mPLNM. Because of the inverse association between ET and mPLNM, higher ET levels were protective against aggressive disease. The influence of locally advanced PCa with high metastatic load on ET levels needs to be explored by controlled trials.</description><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-021-02938-z</identifier><identifier>PMID: 34228260</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Aged ; Biopsy ; Cancer surgery ; Clinical trials ; Humans ; Lymph Node Excision - methods ; Lymph nodes ; Lymphatic Metastasis ; Lymphatic system ; Male ; Medicine ; Medicine &amp; Public Health ; Metastases ; Metastasis ; Middle Aged ; Multivariate analysis ; Nephrology ; Patients ; Pelvis ; Prostate cancer ; Prostatectomy ; Prostatectomy - methods ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - surgery ; Retrospective Studies ; Testosterone ; Testosterone - blood ; Urological surgery ; Urology ; Urology - Original Paper</subject><ispartof>International urology and nephrology, 2021-10, Vol.53 (10), p.2027-2039</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-83127c6b6794e19c09e2b9911ef3b1a555d0f13c15705cbdf7090c485b9404ec3</citedby><cites>FETCH-LOGICAL-c474t-83127c6b6794e19c09e2b9911ef3b1a555d0f13c15705cbdf7090c485b9404ec3</cites><orcidid>0000-0002-7890-040X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11255-021-02938-z$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11255-021-02938-z$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34228260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Porcaro, Antonio Benito</creatorcontrib><creatorcontrib>Cerrato, Clara</creatorcontrib><creatorcontrib>Tafuri, Alessandro</creatorcontrib><creatorcontrib>Bianchi, Alberto</creatorcontrib><creatorcontrib>Gallina, Sebastian</creatorcontrib><creatorcontrib>Orlando, Rossella</creatorcontrib><creatorcontrib>Amigoni, Nelia</creatorcontrib><creatorcontrib>Rizzetto, Riccardo</creatorcontrib><creatorcontrib>Gozzo, Alessandra</creatorcontrib><creatorcontrib>Migliorini, Filippo</creatorcontrib><creatorcontrib>Zecchini Antoniolli, Stefano</creatorcontrib><creatorcontrib>Monaco, Carmelo</creatorcontrib><creatorcontrib>Brunelli, Matteo</creatorcontrib><creatorcontrib>Cerruto, Maria Angela</creatorcontrib><creatorcontrib>Antonelli, Alessandro</creatorcontrib><title>Low endogenous testosterone levels are associated with the extend of lymphnodal invasion at radical prostatectomy and extended pelvic lymph node dissection</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description>Objective To investigate clinical factors associated to lymphnodal metastasis load in patients who underwent to radical prostatectomy (RP) and extended pelvic lymph node dissection (ePLND). Materials and methods Between November 2014 and December 2019, ET was measured in 617 consecutive patients not under androgen deprivation therapy who underwent RP and ePLND. Lymphnode invasion (LNI) was codified as not present ( N  = 0) or with one ( N  = 1) or more than one metastatic node ( N  &gt; 1). The risk of multiple pelvic lymph node metastasis ( N  &gt; 1, mPLNM) was assessed by comparing it to the other two groups ( N  &gt; 1 vs. N  = 0 and N  &gt; 1 vs. N  = 1). Then, we assessed the association between ET and lymphnode invasion for standard predictors, such as PSA, percentage of biopsy positive cores (BPC), tumor stage greater than 1 (cT &gt; 1) and tumor grade group greater than two (ISUP &gt; 2). Results Overall, LNI was detected in 70 patients (11.3%) of whom 39 (6.3%) with N  = 1 and 31 (5%) with N  &gt; 1. On multivariate analysis, ET was inversely associated with the risk of N  &gt; 1 when compared to both N  = 0 (odds ratio, OR 0.997; CI 0.994–1; p  = 0.027) as well as with N  = 1 cases (OR 0.994; 95% CI 0.989–1.000; p  = 0.015). Conclusions In clinical PCa, the risk of mPLNM was increased by low ET levels. As ET decreased, patients had an increased likelihood of mPLNM. Because of the inverse association between ET and mPLNM, higher ET levels were protective against aggressive disease. The influence of locally advanced PCa with high metastatic load on ET levels needs to be explored by controlled trials.</description><subject>Aged</subject><subject>Biopsy</subject><subject>Cancer surgery</subject><subject>Clinical trials</subject><subject>Humans</subject><subject>Lymph Node Excision - methods</subject><subject>Lymph nodes</subject><subject>Lymphatic Metastasis</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Nephrology</subject><subject>Patients</subject><subject>Pelvis</subject><subject>Prostate cancer</subject><subject>Prostatectomy</subject><subject>Prostatectomy - methods</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Retrospective Studies</subject><subject>Testosterone</subject><subject>Testosterone - blood</subject><subject>Urological surgery</subject><subject>Urology</subject><subject>Urology - Original Paper</subject><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUtv1DAUhSMEokPhD7BAltiwCfiZxBskVPGSRmIDa8txbmZcJXawPdNO_wp_lgsp5bFgYVnyPeezfU5VPWX0JaO0fZUZ40rVlDNcWnT1zb1qw1Qraq46eb_aUEFZzRouzqpHOV9SSnVH6cPqTEjOO97QTfVtG68IhCHuIMRDJgVyiblAigHIBEeYMrEJiM05Om8LDOTKlz0peyBwXdBJ4kim07zsQxzsRHw42uxjILaQZAfv8GxJiESvK3E-EYue1YqwBaajdyuAIAHI4HNGJSIeVw9GO2V4crufV1_evf188aHefnr_8eLNtnaylaXuBOOta_qm1RKYdlQD77VmDEbRM6uUGujIhMNkqHL9MLZUUyc71WtJJThxXr1eucuhn2FwEEqyk1mSn206mWi9-XsS_N7s4tF0shFCKQS8uAWk-PWACZrZZwfTZANgqIYr2Wnailag9Pk_0st4SAG_h6q2YZJpzlDFV5XD5HKC8e4xjJof3Zu1e4Pdm5_dmxs0PfvzG3eWX2WjQKyCjKOwg_T77v9gvwPFcL80</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Porcaro, Antonio Benito</creator><creator>Cerrato, Clara</creator><creator>Tafuri, Alessandro</creator><creator>Bianchi, Alberto</creator><creator>Gallina, Sebastian</creator><creator>Orlando, Rossella</creator><creator>Amigoni, Nelia</creator><creator>Rizzetto, Riccardo</creator><creator>Gozzo, Alessandra</creator><creator>Migliorini, Filippo</creator><creator>Zecchini Antoniolli, Stefano</creator><creator>Monaco, Carmelo</creator><creator>Brunelli, Matteo</creator><creator>Cerruto, Maria Angela</creator><creator>Antonelli, Alessandro</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7890-040X</orcidid></search><sort><creationdate>20211001</creationdate><title>Low endogenous testosterone levels are associated with the extend of lymphnodal invasion at radical prostatectomy and extended pelvic lymph node dissection</title><author>Porcaro, Antonio Benito ; Cerrato, Clara ; Tafuri, Alessandro ; Bianchi, Alberto ; Gallina, Sebastian ; Orlando, Rossella ; Amigoni, Nelia ; Rizzetto, Riccardo ; Gozzo, Alessandra ; Migliorini, Filippo ; Zecchini Antoniolli, Stefano ; Monaco, Carmelo ; Brunelli, Matteo ; Cerruto, Maria Angela ; Antonelli, Alessandro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-83127c6b6794e19c09e2b9911ef3b1a555d0f13c15705cbdf7090c485b9404ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Biopsy</topic><topic>Cancer surgery</topic><topic>Clinical trials</topic><topic>Humans</topic><topic>Lymph Node Excision - methods</topic><topic>Lymph nodes</topic><topic>Lymphatic Metastasis</topic><topic>Lymphatic system</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Nephrology</topic><topic>Patients</topic><topic>Pelvis</topic><topic>Prostate cancer</topic><topic>Prostatectomy</topic><topic>Prostatectomy - methods</topic><topic>Prostatic Neoplasms - blood</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Retrospective Studies</topic><topic>Testosterone</topic><topic>Testosterone - blood</topic><topic>Urological surgery</topic><topic>Urology</topic><topic>Urology - Original Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Porcaro, Antonio Benito</creatorcontrib><creatorcontrib>Cerrato, Clara</creatorcontrib><creatorcontrib>Tafuri, Alessandro</creatorcontrib><creatorcontrib>Bianchi, Alberto</creatorcontrib><creatorcontrib>Gallina, Sebastian</creatorcontrib><creatorcontrib>Orlando, Rossella</creatorcontrib><creatorcontrib>Amigoni, Nelia</creatorcontrib><creatorcontrib>Rizzetto, Riccardo</creatorcontrib><creatorcontrib>Gozzo, Alessandra</creatorcontrib><creatorcontrib>Migliorini, Filippo</creatorcontrib><creatorcontrib>Zecchini Antoniolli, Stefano</creatorcontrib><creatorcontrib>Monaco, Carmelo</creatorcontrib><creatorcontrib>Brunelli, Matteo</creatorcontrib><creatorcontrib>Cerruto, Maria Angela</creatorcontrib><creatorcontrib>Antonelli, Alessandro</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Porcaro, Antonio Benito</au><au>Cerrato, Clara</au><au>Tafuri, Alessandro</au><au>Bianchi, Alberto</au><au>Gallina, Sebastian</au><au>Orlando, Rossella</au><au>Amigoni, Nelia</au><au>Rizzetto, Riccardo</au><au>Gozzo, Alessandra</au><au>Migliorini, Filippo</au><au>Zecchini Antoniolli, Stefano</au><au>Monaco, Carmelo</au><au>Brunelli, Matteo</au><au>Cerruto, Maria Angela</au><au>Antonelli, Alessandro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low endogenous testosterone levels are associated with the extend of lymphnodal invasion at radical prostatectomy and extended pelvic lymph node dissection</atitle><jtitle>International urology and nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>53</volume><issue>10</issue><spage>2027</spage><epage>2039</epage><pages>2027-2039</pages><issn>0301-1623</issn><eissn>1573-2584</eissn><abstract>Objective To investigate clinical factors associated to lymphnodal metastasis load in patients who underwent to radical prostatectomy (RP) and extended pelvic lymph node dissection (ePLND). Materials and methods Between November 2014 and December 2019, ET was measured in 617 consecutive patients not under androgen deprivation therapy who underwent RP and ePLND. Lymphnode invasion (LNI) was codified as not present ( N  = 0) or with one ( N  = 1) or more than one metastatic node ( N  &gt; 1). The risk of multiple pelvic lymph node metastasis ( N  &gt; 1, mPLNM) was assessed by comparing it to the other two groups ( N  &gt; 1 vs. N  = 0 and N  &gt; 1 vs. N  = 1). Then, we assessed the association between ET and lymphnode invasion for standard predictors, such as PSA, percentage of biopsy positive cores (BPC), tumor stage greater than 1 (cT &gt; 1) and tumor grade group greater than two (ISUP &gt; 2). Results Overall, LNI was detected in 70 patients (11.3%) of whom 39 (6.3%) with N  = 1 and 31 (5%) with N  &gt; 1. On multivariate analysis, ET was inversely associated with the risk of N  &gt; 1 when compared to both N  = 0 (odds ratio, OR 0.997; CI 0.994–1; p  = 0.027) as well as with N  = 1 cases (OR 0.994; 95% CI 0.989–1.000; p  = 0.015). Conclusions In clinical PCa, the risk of mPLNM was increased by low ET levels. As ET decreased, patients had an increased likelihood of mPLNM. Because of the inverse association between ET and mPLNM, higher ET levels were protective against aggressive disease. The influence of locally advanced PCa with high metastatic load on ET levels needs to be explored by controlled trials.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>34228260</pmid><doi>10.1007/s11255-021-02938-z</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-7890-040X</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0301-1623
ispartof International urology and nephrology, 2021-10, Vol.53 (10), p.2027-2039
issn 0301-1623
1573-2584
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8463355
source MEDLINE; SpringerLink Journals - AutoHoldings
subjects Aged
Biopsy
Cancer surgery
Clinical trials
Humans
Lymph Node Excision - methods
Lymph nodes
Lymphatic Metastasis
Lymphatic system
Male
Medicine
Medicine & Public Health
Metastases
Metastasis
Middle Aged
Multivariate analysis
Nephrology
Patients
Pelvis
Prostate cancer
Prostatectomy
Prostatectomy - methods
Prostatic Neoplasms - blood
Prostatic Neoplasms - pathology
Prostatic Neoplasms - surgery
Retrospective Studies
Testosterone
Testosterone - blood
Urological surgery
Urology
Urology - Original Paper
title Low endogenous testosterone levels are associated with the extend of lymphnodal invasion at radical prostatectomy and extended pelvic lymph node dissection
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T04%3A06%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low%20endogenous%20testosterone%20levels%20are%20associated%20with%20the%20extend%20of%20lymphnodal%20invasion%20at%20radical%20prostatectomy%20and%20extended%20pelvic%20lymph%20node%20dissection&rft.jtitle=International%20urology%20and%20nephrology&rft.au=Porcaro,%20Antonio%20Benito&rft.date=2021-10-01&rft.volume=53&rft.issue=10&rft.spage=2027&rft.epage=2039&rft.pages=2027-2039&rft.issn=0301-1623&rft.eissn=1573-2584&rft_id=info:doi/10.1007/s11255-021-02938-z&rft_dat=%3Cproquest_pubme%3E2548907373%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2576141921&rft_id=info:pmid/34228260&rfr_iscdi=true