Neoadjuvant intraperitoneal chemotherapy for advanced stage gastric cancer (Review)
Gastric cancer remains one of the most lethal malignancies especially when diagnosed in advanced stages of the disease; most often patients diagnosed later during the progression of their disease will present a certain degree of peritoneal contamination such as positive peritoneal cytology or perito...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2021-11, Vol.22 (5), Article 1314 |
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| container_title | Experimental and therapeutic medicine |
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| creator | Bacalbasa, Nicolae Diaconu, Camelia Socea, Bogdan Gherghiceanu, Florentina Savu, Cornel Dimitriu, Mihai Balescu, Irina Cordos, Ioan |
| description | Gastric cancer remains one of the most lethal malignancies especially when diagnosed in advanced stages of the disease; most often patients diagnosed later during the progression of their disease will present a certain degree of peritoneal contamination such as positive peritoneal cytology or peritoneal metastatic nodules. In such cases most often they then progress to peritoneal carcinomatosis and succumb to the disease within one year. In order to increase the lifespan in such cases multiple therapeutic strategies have been proposed such as radical surgery and intraperitoneal heated chemotherapy or direct intraperitoneal chemotherapy followed by radical surgery. To date, the benefits of intraperitoneal heated chemotherapy at the time of resection have been widely investigated; however the method is still associated with increased rates of perioperative complications. Therefore, attention was focused on investigating the benefits of such procedures as neoadjuvant therapies followed by radical surgery. The aim of the present review was to examine the most efficient therapeutic strategies in advanced-stage gastric cancer such as neoadjuvant laparoscopic heated intraperitoneal chemotherapy, perioperative heated intraperitoneal chemotherapy and neoadjuvant systemic and peritoneal chemotherapy. |
| doi_str_mv | 10.3892/etm.2021.10749 |
| format | Article |
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In such cases most often they then progress to peritoneal carcinomatosis and succumb to the disease within one year. In order to increase the lifespan in such cases multiple therapeutic strategies have been proposed such as radical surgery and intraperitoneal heated chemotherapy or direct intraperitoneal chemotherapy followed by radical surgery. To date, the benefits of intraperitoneal heated chemotherapy at the time of resection have been widely investigated; however the method is still associated with increased rates of perioperative complications. Therefore, attention was focused on investigating the benefits of such procedures as neoadjuvant therapies followed by radical surgery. The aim of the present review was to examine the most efficient therapeutic strategies in advanced-stage gastric cancer such as neoadjuvant laparoscopic heated intraperitoneal chemotherapy, perioperative heated intraperitoneal chemotherapy and neoadjuvant systemic and peritoneal chemotherapy.</description><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1015</identifier><identifier>DOI: 10.3892/etm.2021.10749</identifier><identifier>PMID: 34630668</identifier><language>eng</language><publisher>Athens: Spandidos Publications</publisher><subject>Cancer ; Cancer therapies ; Cellular biology ; Chemotherapy ; Cytotoxicity ; Drug therapy ; Gastric cancer ; Gastrointestinal surgery ; Laparoscopy ; Lymphatic system ; Metastasis ; Methods ; Morbidity ; Neoadjuvant therapy ; Review ; Stomach cancer</subject><ispartof>Experimental and therapeutic medicine, 2021-11, Vol.22 (5), Article 1314</ispartof><rights>COPYRIGHT 2021 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2021</rights><rights>Copyright © 2020, Spandidos Publications 2020</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-82014965da0d2f18dbac85344dcea29798425d46250982bc7b6512e70bf218e3</citedby><cites>FETCH-LOGICAL-c392t-82014965da0d2f18dbac85344dcea29798425d46250982bc7b6512e70bf218e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461609/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461609/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Bacalbasa, Nicolae</creatorcontrib><creatorcontrib>Diaconu, Camelia</creatorcontrib><creatorcontrib>Socea, Bogdan</creatorcontrib><creatorcontrib>Gherghiceanu, Florentina</creatorcontrib><creatorcontrib>Savu, Cornel</creatorcontrib><creatorcontrib>Dimitriu, Mihai</creatorcontrib><creatorcontrib>Balescu, Irina</creatorcontrib><creatorcontrib>Cordos, Ioan</creatorcontrib><title>Neoadjuvant intraperitoneal chemotherapy for advanced stage gastric cancer (Review)</title><title>Experimental and therapeutic medicine</title><description>Gastric cancer remains one of the most lethal malignancies especially when diagnosed in advanced stages of the disease; most often patients diagnosed later during the progression of their disease will present a certain degree of peritoneal contamination such as positive peritoneal cytology or peritoneal metastatic nodules. 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The aim of the present review was to examine the most efficient therapeutic strategies in advanced-stage gastric cancer such as neoadjuvant laparoscopic heated intraperitoneal chemotherapy, perioperative heated intraperitoneal chemotherapy and neoadjuvant systemic and peritoneal chemotherapy.</description><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Cellular biology</subject><subject>Chemotherapy</subject><subject>Cytotoxicity</subject><subject>Drug therapy</subject><subject>Gastric cancer</subject><subject>Gastrointestinal surgery</subject><subject>Laparoscopy</subject><subject>Lymphatic system</subject><subject>Metastasis</subject><subject>Methods</subject><subject>Morbidity</subject><subject>Neoadjuvant therapy</subject><subject>Review</subject><subject>Stomach cancer</subject><issn>1792-0981</issn><issn>1792-1015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptUU1LAzEUDKKoqFfPC1700JqPTTa5CCJ-gSio95BN3rYp3U1N0or_3lSLIph3yGMyb5iXQeiY4DGTip5D7scUUzImuKnVFtonjaIjggnf3vRYSbKHjlKa4XK4IFLyXbTHasGwEHIfvTxCMG62XJkhV37I0Swg-hwGMPPKTqEPeQoF_Ki6ECvjCs-Cq1I2E6gmJuXobWXXYKxOn2Hl4f3sEO10Zp7gaHMfoNeb69eru9HD0-391eXDyDJF80hSTGoluDPY0Y5I1xorOatrZ8FQ1ShZU-5qQXnZgra2aQUnFBrcdpRIYAfo4lt2sWx7KENr93O9iL438UMH4_Xfl8FP9SSstKwFEVgVgZONQAxvS0hZz8IyDsWyplxSxQQXzS9rYuag_dCFImZ7n6y-FJI1FCsiCmv8D6uUg97b8p2dL_h_AzaGlCJ0P8YJ1ut0dUlXr9PVX-myT_1Elb8</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Bacalbasa, Nicolae</creator><creator>Diaconu, Camelia</creator><creator>Socea, Bogdan</creator><creator>Gherghiceanu, Florentina</creator><creator>Savu, Cornel</creator><creator>Dimitriu, Mihai</creator><creator>Balescu, Irina</creator><creator>Cordos, Ioan</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. 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| subjects | Cancer Cancer therapies Cellular biology Chemotherapy Cytotoxicity Drug therapy Gastric cancer Gastrointestinal surgery Laparoscopy Lymphatic system Metastasis Methods Morbidity Neoadjuvant therapy Review Stomach cancer |
| title | Neoadjuvant intraperitoneal chemotherapy for advanced stage gastric cancer (Review) |
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