The Alteration of Brain Interstitial Fluid Drainage with Myelination Development

The integrity of myelination is crucial for maintaining brain interstitial fluid (ISF) drainage in adults; however, the mechanism of ISF drainage with immature myelin in the developing brain remains unknown. In the present study, the ISF drainage from the caudate nucleus (Cn) to the ipsilateral cort...

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Veröffentlicht in:Aging and disease 2021-10, Vol.12 (7), p.1729-1740
Hauptverfasser: Wang, Rui, Han, Hongbin, Shi, Kuangyu, Alberts, Ian Leigh, Rominger, Axel, Yang, Chenlong, Yan, Junhao, Cui, Dehua, Peng, Yun, He, Qingyuan, Gao, Yajuan, Lian, Jingge, Yang, Shuangfeng, Liu, Huipo, Yang, Jun, Wong, Chaolan, Wei, Xunbin, Yin, Feng, Jia, Yanxing, Tong, Huaiyu, Liu, Bo, Lei, Jianbo
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container_end_page 1740
container_issue 7
container_start_page 1729
container_title Aging and disease
container_volume 12
creator Wang, Rui
Han, Hongbin
Shi, Kuangyu
Alberts, Ian Leigh
Rominger, Axel
Yang, Chenlong
Yan, Junhao
Cui, Dehua
Peng, Yun
He, Qingyuan
Gao, Yajuan
Lian, Jingge
Yang, Shuangfeng
Liu, Huipo
Yang, Jun
Wong, Chaolan
Wei, Xunbin
Yin, Feng
Jia, Yanxing
Tong, Huaiyu
Liu, Bo
Lei, Jianbo
description The integrity of myelination is crucial for maintaining brain interstitial fluid (ISF) drainage in adults; however, the mechanism of ISF drainage with immature myelin in the developing brain remains unknown. In the present study, the ISF drainage from the caudate nucleus (Cn) to the ipsilateral cortex was studied at different developmental stages of the rat brain (P 10, 20, 30, 40, 60, 80, 10-80). The results show that the traced ISF drained to the cortex from Cn and to the thalamus in an opposite direction before P30. From P40, we found impeded drainage to the thalamus due to myelin maturation. This altered drainage was accompanied by enhanced cognitive and social functions, which were consistent with those in the adult rats. A significant difference in diffusion parameters was also demonstrated between the extracellular space (ECS) before and after P30. The present study revealed the alteration of ISF drainage regulated by myelin at different stages during development, indicating that a regional ISF homeostasis may be essential for mature psychological and cognitive functions.
doi_str_mv 10.14336/AD.2021.0305
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however, the mechanism of ISF drainage with immature myelin in the developing brain remains unknown. In the present study, the ISF drainage from the caudate nucleus (Cn) to the ipsilateral cortex was studied at different developmental stages of the rat brain (P 10, 20, 30, 40, 60, 80, 10-80). The results show that the traced ISF drained to the cortex from Cn and to the thalamus in an opposite direction before P30. From P40, we found impeded drainage to the thalamus due to myelin maturation. This altered drainage was accompanied by enhanced cognitive and social functions, which were consistent with those in the adult rats. A significant difference in diffusion parameters was also demonstrated between the extracellular space (ECS) before and after P30. The present study revealed the alteration of ISF drainage regulated by myelin at different stages during development, indicating that a regional ISF homeostasis may be essential for mature psychological and cognitive functions.</abstract><cop>FORT WORTH</cop><pub>Int Soc Aging &amp; Disease</pub><pmid>34631217</pmid><doi>10.14336/AD.2021.0305</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record>
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subjects Caudate nucleus
Cerebrospinal fluid
Geriatrics & Gerontology
Health aspects
Life Sciences & Biomedicine
Myelin proteins
Orginal
Physiological aspects
Science & Technology
title The Alteration of Brain Interstitial Fluid Drainage with Myelination Development
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