The Alteration of Brain Interstitial Fluid Drainage with Myelination Development
The integrity of myelination is crucial for maintaining brain interstitial fluid (ISF) drainage in adults; however, the mechanism of ISF drainage with immature myelin in the developing brain remains unknown. In the present study, the ISF drainage from the caudate nucleus (Cn) to the ipsilateral cort...
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| Veröffentlicht in: | Aging and disease 2021-10, Vol.12 (7), p.1729-1740 |
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| creator | Wang, Rui Han, Hongbin Shi, Kuangyu Alberts, Ian Leigh Rominger, Axel Yang, Chenlong Yan, Junhao Cui, Dehua Peng, Yun He, Qingyuan Gao, Yajuan Lian, Jingge Yang, Shuangfeng Liu, Huipo Yang, Jun Wong, Chaolan Wei, Xunbin Yin, Feng Jia, Yanxing Tong, Huaiyu Liu, Bo Lei, Jianbo |
| description | The integrity of myelination is crucial for maintaining brain interstitial fluid (ISF) drainage in adults; however, the mechanism of ISF drainage with immature myelin in the developing brain remains unknown. In the present study, the ISF drainage from the caudate nucleus (Cn) to the ipsilateral cortex was studied at different developmental stages of the rat brain (P 10, 20, 30, 40, 60, 80, 10-80). The results show that the traced ISF drained to the cortex from Cn and to the thalamus in an opposite direction before P30. From P40, we found impeded drainage to the thalamus due to myelin maturation. This altered drainage was accompanied by enhanced cognitive and social functions, which were consistent with those in the adult rats. A significant difference in diffusion parameters was also demonstrated between the extracellular space (ECS) before and after P30. The present study revealed the alteration of ISF drainage regulated by myelin at different stages during development, indicating that a regional ISF homeostasis may be essential for mature psychological and cognitive functions. |
| doi_str_mv | 10.14336/AD.2021.0305 |
| format | Article |
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In the present study, the ISF drainage from the caudate nucleus (Cn) to the ipsilateral cortex was studied at different developmental stages of the rat brain (P 10, 20, 30, 40, 60, 80, 10-80). The results show that the traced ISF drained to the cortex from Cn and to the thalamus in an opposite direction before P30. From P40, we found impeded drainage to the thalamus due to myelin maturation. This altered drainage was accompanied by enhanced cognitive and social functions, which were consistent with those in the adult rats. A significant difference in diffusion parameters was also demonstrated between the extracellular space (ECS) before and after P30. The present study revealed the alteration of ISF drainage regulated by myelin at different stages during development, indicating that a regional ISF homeostasis may be essential for mature psychological and cognitive functions.</description><identifier>ISSN: 2152-5250</identifier><identifier>EISSN: 2152-5250</identifier><identifier>DOI: 10.14336/AD.2021.0305</identifier><identifier>PMID: 34631217</identifier><language>eng</language><publisher>FORT WORTH: Int Soc Aging & Disease</publisher><subject>Caudate nucleus ; Cerebrospinal fluid ; Geriatrics & Gerontology ; Health aspects ; Life Sciences & Biomedicine ; Myelin proteins ; Orginal ; Physiological aspects ; Science & Technology</subject><ispartof>Aging and disease, 2021-10, Vol.12 (7), p.1729-1740</ispartof><rights>COPYRIGHT 2021 JKL International</rights><rights>copyright: © 2021 Wang et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>13</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000705563500016</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c462t-9b9a8d49ea8735a010ce588f56fe6cba66fcf660fe34e599c8a49d09479450db3</citedby><cites>FETCH-LOGICAL-c462t-9b9a8d49ea8735a010ce588f56fe6cba66fcf660fe34e599c8a49d09479450db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460314/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460314/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2116,27931,27932,39265,53798,53800</link.rule.ids></links><search><creatorcontrib>Wang, Rui</creatorcontrib><creatorcontrib>Han, Hongbin</creatorcontrib><creatorcontrib>Shi, Kuangyu</creatorcontrib><creatorcontrib>Alberts, Ian Leigh</creatorcontrib><creatorcontrib>Rominger, Axel</creatorcontrib><creatorcontrib>Yang, Chenlong</creatorcontrib><creatorcontrib>Yan, Junhao</creatorcontrib><creatorcontrib>Cui, Dehua</creatorcontrib><creatorcontrib>Peng, Yun</creatorcontrib><creatorcontrib>He, Qingyuan</creatorcontrib><creatorcontrib>Gao, Yajuan</creatorcontrib><creatorcontrib>Lian, Jingge</creatorcontrib><creatorcontrib>Yang, Shuangfeng</creatorcontrib><creatorcontrib>Liu, Huipo</creatorcontrib><creatorcontrib>Yang, Jun</creatorcontrib><creatorcontrib>Wong, Chaolan</creatorcontrib><creatorcontrib>Wei, Xunbin</creatorcontrib><creatorcontrib>Yin, Feng</creatorcontrib><creatorcontrib>Jia, Yanxing</creatorcontrib><creatorcontrib>Tong, Huaiyu</creatorcontrib><creatorcontrib>Liu, Bo</creatorcontrib><creatorcontrib>Lei, Jianbo</creatorcontrib><title>The Alteration of Brain Interstitial Fluid Drainage with Myelination Development</title><title>Aging and disease</title><addtitle>AGING DIS</addtitle><description>The integrity of myelination is crucial for maintaining brain interstitial fluid (ISF) drainage in adults; however, the mechanism of ISF drainage with immature myelin in the developing brain remains unknown. In the present study, the ISF drainage from the caudate nucleus (Cn) to the ipsilateral cortex was studied at different developmental stages of the rat brain (P 10, 20, 30, 40, 60, 80, 10-80). The results show that the traced ISF drained to the cortex from Cn and to the thalamus in an opposite direction before P30. From P40, we found impeded drainage to the thalamus due to myelin maturation. This altered drainage was accompanied by enhanced cognitive and social functions, which were consistent with those in the adult rats. A significant difference in diffusion parameters was also demonstrated between the extracellular space (ECS) before and after P30. The present study revealed the alteration of ISF drainage regulated by myelin at different stages during development, indicating that a regional ISF homeostasis may be essential for mature psychological and cognitive functions.</description><subject>Caudate nucleus</subject><subject>Cerebrospinal fluid</subject><subject>Geriatrics & Gerontology</subject><subject>Health aspects</subject><subject>Life Sciences & Biomedicine</subject><subject>Myelin proteins</subject><subject>Orginal</subject><subject>Physiological aspects</subject><subject>Science & Technology</subject><issn>2152-5250</issn><issn>2152-5250</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><recordid>eNqNklGL3CAQx0Np6R3be-x7oFAKJVuN0cSXQm631x5caR-uz2LMuLEY3UZzx337mt3juIU-VBHHmd9_xHGy7C1Ga1wRwj6123WJSrxGBNEX2XmJaVnQkqKXz-yz7CKE3ygNwkvCyevsjFSM4BLX59nP2wHy1kaYZDTe5V7nl5M0Lr92yReiiUba_MrOps-3S0DuIL83cci_P4BNx4NqC3dg_X4EF99kr7S0AS4e91X26-rL7eZbcfPj6_WmvSlUxcpY8I7Lpq84yKYmVCKMFNCm0ZRpYKqTjGmlGUMaSAWUc9XIiveIVzWvKOo7sso-H_Pu526EXqWrJ2nFfjKjnB6El0acRpwZxM7fiaZiiKTqrbIPjwkm_2eGEMVoggJrpQM_B1HSBvG0KE_ouyO6kxaEcdqnjGrBRcsSxRGuSaLW_6DS7GE0yjvQJvlPBO-fCQaQNg7B23kpaTgFiyOoJh_CBPrpmRiJQyOIdiuWRhBLIyS-OfL30HkdlAGn4EmTGqFGlDJCk4XZxsTDJ2787GKSfvx_KfkLHabDFQ</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Wang, Rui</creator><creator>Han, Hongbin</creator><creator>Shi, Kuangyu</creator><creator>Alberts, Ian Leigh</creator><creator>Rominger, Axel</creator><creator>Yang, Chenlong</creator><creator>Yan, Junhao</creator><creator>Cui, Dehua</creator><creator>Peng, Yun</creator><creator>He, Qingyuan</creator><creator>Gao, Yajuan</creator><creator>Lian, Jingge</creator><creator>Yang, Shuangfeng</creator><creator>Liu, Huipo</creator><creator>Yang, Jun</creator><creator>Wong, Chaolan</creator><creator>Wei, Xunbin</creator><creator>Yin, Feng</creator><creator>Jia, Yanxing</creator><creator>Tong, Huaiyu</creator><creator>Liu, Bo</creator><creator>Lei, Jianbo</creator><general>Int Soc Aging & Disease</general><general>JKL International</general><general>JKL International LLC</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211001</creationdate><title>The Alteration of Brain Interstitial Fluid Drainage with Myelination Development</title><author>Wang, Rui ; Han, Hongbin ; Shi, Kuangyu ; Alberts, Ian Leigh ; Rominger, Axel ; Yang, Chenlong ; Yan, Junhao ; Cui, Dehua ; Peng, Yun ; He, Qingyuan ; Gao, Yajuan ; Lian, Jingge ; Yang, Shuangfeng ; Liu, Huipo ; Yang, Jun ; Wong, Chaolan ; Wei, Xunbin ; Yin, Feng ; Jia, Yanxing ; Tong, Huaiyu ; Liu, Bo ; Lei, Jianbo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-9b9a8d49ea8735a010ce588f56fe6cba66fcf660fe34e599c8a49d09479450db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Caudate nucleus</topic><topic>Cerebrospinal fluid</topic><topic>Geriatrics & Gerontology</topic><topic>Health aspects</topic><topic>Life Sciences & Biomedicine</topic><topic>Myelin proteins</topic><topic>Orginal</topic><topic>Physiological aspects</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Rui</creatorcontrib><creatorcontrib>Han, Hongbin</creatorcontrib><creatorcontrib>Shi, Kuangyu</creatorcontrib><creatorcontrib>Alberts, Ian Leigh</creatorcontrib><creatorcontrib>Rominger, Axel</creatorcontrib><creatorcontrib>Yang, Chenlong</creatorcontrib><creatorcontrib>Yan, Junhao</creatorcontrib><creatorcontrib>Cui, Dehua</creatorcontrib><creatorcontrib>Peng, Yun</creatorcontrib><creatorcontrib>He, Qingyuan</creatorcontrib><creatorcontrib>Gao, Yajuan</creatorcontrib><creatorcontrib>Lian, Jingge</creatorcontrib><creatorcontrib>Yang, Shuangfeng</creatorcontrib><creatorcontrib>Liu, Huipo</creatorcontrib><creatorcontrib>Yang, Jun</creatorcontrib><creatorcontrib>Wong, Chaolan</creatorcontrib><creatorcontrib>Wei, Xunbin</creatorcontrib><creatorcontrib>Yin, Feng</creatorcontrib><creatorcontrib>Jia, Yanxing</creatorcontrib><creatorcontrib>Tong, Huaiyu</creatorcontrib><creatorcontrib>Liu, Bo</creatorcontrib><creatorcontrib>Lei, Jianbo</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging and disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Rui</au><au>Han, Hongbin</au><au>Shi, Kuangyu</au><au>Alberts, Ian Leigh</au><au>Rominger, Axel</au><au>Yang, Chenlong</au><au>Yan, Junhao</au><au>Cui, Dehua</au><au>Peng, Yun</au><au>He, Qingyuan</au><au>Gao, Yajuan</au><au>Lian, Jingge</au><au>Yang, Shuangfeng</au><au>Liu, Huipo</au><au>Yang, Jun</au><au>Wong, Chaolan</au><au>Wei, Xunbin</au><au>Yin, Feng</au><au>Jia, Yanxing</au><au>Tong, Huaiyu</au><au>Liu, Bo</au><au>Lei, Jianbo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Alteration of Brain Interstitial Fluid Drainage with Myelination Development</atitle><jtitle>Aging and disease</jtitle><stitle>AGING DIS</stitle><date>2021-10-01</date><risdate>2021</risdate><volume>12</volume><issue>7</issue><spage>1729</spage><epage>1740</epage><pages>1729-1740</pages><issn>2152-5250</issn><eissn>2152-5250</eissn><abstract>The integrity of myelination is crucial for maintaining brain interstitial fluid (ISF) drainage in adults; however, the mechanism of ISF drainage with immature myelin in the developing brain remains unknown. In the present study, the ISF drainage from the caudate nucleus (Cn) to the ipsilateral cortex was studied at different developmental stages of the rat brain (P 10, 20, 30, 40, 60, 80, 10-80). The results show that the traced ISF drained to the cortex from Cn and to the thalamus in an opposite direction before P30. From P40, we found impeded drainage to the thalamus due to myelin maturation. This altered drainage was accompanied by enhanced cognitive and social functions, which were consistent with those in the adult rats. A significant difference in diffusion parameters was also demonstrated between the extracellular space (ECS) before and after P30. The present study revealed the alteration of ISF drainage regulated by myelin at different stages during development, indicating that a regional ISF homeostasis may be essential for mature psychological and cognitive functions.</abstract><cop>FORT WORTH</cop><pub>Int Soc Aging & Disease</pub><pmid>34631217</pmid><doi>10.14336/AD.2021.0305</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Caudate nucleus Cerebrospinal fluid Geriatrics & Gerontology Health aspects Life Sciences & Biomedicine Myelin proteins Orginal Physiological aspects Science & Technology |
| title | The Alteration of Brain Interstitial Fluid Drainage with Myelination Development |
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