A Critical Role of Formyl Peptide Receptors in Host Defense against Escherichia coli

Formyl peptide receptors (FPRs, mouse Fprs) belong to the G protein-coupled receptor superfamily and mediate phagocyte migration in response to bacteria- and host-derived chemoattractants; however, knowledge about their in vivo roles in bacterial pathogenesis is limited. In this study, we investigat...

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Veröffentlicht in:	The Journal of immunology (1950) 2020-05, Vol.204 (9), p.2464-2473
Hauptverfasser:	Zhang, Meihua, Gao, Ji-Liang, Chen, Keqiang, Yoshimura, Teizo, Liang, Weiwei, Gong, Wanghua, Li, Xiaoqing, Huang, Jiaqiang, McDermott, David H, Murphy, Philip M, Wang, Xietong, Wang, Ji Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow - immunology Bone Marrow - metabolism Bone Marrow - microbiology Cells, Cultured Chemotaxis - immunology Escherichia coli - immunology Escherichia coli Infections - immunology Escherichia coli Infections - metabolism HEK293 Cells Humans Liver - immunology Liver - metabolism Liver - microbiology Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinases - immunology Mitogen-Activated Protein Kinases - metabolism Neutrophils - immunology Neutrophils - metabolism Neutrophils - microbiology Peritoneal Cavity - microbiology Phagocytosis - immunology Phosphorylation - immunology Receptors, Formyl Peptide - immunology Receptors, Formyl Peptide - metabolism
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