From Kinase Inhibitors to Multitarget Ligands as Powerful Drug Leads for Alzheimer's Disease using Protein‐Templated Synthesis

Multitarget directed ligands (MTDLs) are arising as promising tools to tackle complex diseases. The main goal of this work is to create powerful modulating agents for neurodegenerative disorders. To achieve this aim, we have combined fragments that inhibit key protein kinases involved in the main pa...

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Veröffentlicht in:	Angewandte Chemie International Edition 2021-08, Vol.60 (35), p.19344-19354
Hauptverfasser:	Nozal, Vanesa, García‐Rubia, Alfonso, Cuevas, Eva P., Pérez, Concepción, Tosat‐Bitrián, Carlota, Bartolomé, Fernando, Carro, Eva, Ramírez, David, Palomo, Valle, Martínez, Ana
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Amyloid Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - metabolism Amyloid Precursor Protein Secretases - antagonists & inhibitors Amyloid Precursor Protein Secretases - metabolism Aspartic Acid Endopeptidases - antagonists & inhibitors Aspartic Acid Endopeptidases - metabolism BACE1 Cell Line Chemical synthesis Computational neuroscience Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans in situ click chemistry Inflammation Kinases Ligands Molecular Structure multitarget directed ligands Neurodegenerative diseases Neurogenesis Neuroprotective Agents - chemical synthesis Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology Protein biosynthesis Protein kinase protein kinase inhibitors Proteins Secretase Tau protein Triazoles - chemical synthesis Triazoles - chemistry Triazoles - pharmacology β-Site APP-cleaving enzyme 1
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