Invasive dental procedures as risk factors for postoperative spinal infection and the effect of antibiotic prophylaxis
Aim To identify invasive dental procedures as a risk factor for postoperative spinal infection (PSI) and evaluate the effectiveness of antibiotic prophylaxis. Materials and Methods We analysed 229,335 patients who underwent spinal surgery with instrumentation from 2010 to 2017, using the nationwide...
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| Veröffentlicht in: | Journal of clinical periodontology 2021-09, Vol.48 (9), p.1270-1280 |
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| container_title | Journal of clinical periodontology |
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| creator | Sung, Sahyun Kim, Eun Hwa Kwon, Ji‐Won Lee, Jung‐Seok Lee, Soo‐Bin Moon, Seong‐Hwan Lee, Hwan‐Mo Jung, Inkyung Lee, Byung Ho |
| description | Aim
To identify invasive dental procedures as a risk factor for postoperative spinal infection (PSI) and evaluate the effectiveness of antibiotic prophylaxis.
Materials and Methods
We analysed 229,335 patients who underwent spinal surgery with instrumentation from 2010 to 2017, using the nationwide database. The incidence of spinal infection 2 years after surgery was determined. Invasive dental procedures as a risk factor for PSI and the effects of antibiotic prophylaxis during this period were also analysed.
Results
A total of 15,346 patients (6.69%) were diagnosed with PSI. It was found that advanced age, male sex, and a high Charlson Comorbidity Index were risk factors for PSI. The risk of PSI did not increase following dental procedures (adjusted hazard ratio [HR] 0.850; 95% confidence interval [CI], 0.793–0.912) and was not affected by antibiotics (adjusted HR 1.097; 95% CI, 0.987–1.218). Patients who received dental treatment as early as 3 months after spinal surgery had the lowest risk of postoperative infection (adjusted HR 0.869; 95% CI, 0.795–0.950).
Conclusions
Invasive dental procedure does not increase the risk of PSI, and antibiotic prophylaxis before dental procedure was not effective in preventing spinal infection. |
| doi_str_mv | 10.1111/jcpe.13514 |
| format | Article |
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To identify invasive dental procedures as a risk factor for postoperative spinal infection (PSI) and evaluate the effectiveness of antibiotic prophylaxis.
Materials and Methods
We analysed 229,335 patients who underwent spinal surgery with instrumentation from 2010 to 2017, using the nationwide database. The incidence of spinal infection 2 years after surgery was determined. Invasive dental procedures as a risk factor for PSI and the effects of antibiotic prophylaxis during this period were also analysed.
Results
A total of 15,346 patients (6.69%) were diagnosed with PSI. It was found that advanced age, male sex, and a high Charlson Comorbidity Index were risk factors for PSI. The risk of PSI did not increase following dental procedures (adjusted hazard ratio [HR] 0.850; 95% confidence interval [CI], 0.793–0.912) and was not affected by antibiotics (adjusted HR 1.097; 95% CI, 0.987–1.218). Patients who received dental treatment as early as 3 months after spinal surgery had the lowest risk of postoperative infection (adjusted HR 0.869; 95% CI, 0.795–0.950).
Conclusions
Invasive dental procedure does not increase the risk of PSI, and antibiotic prophylaxis before dental procedure was not effective in preventing spinal infection.</description><identifier>ISSN: 0303-6979</identifier><identifier>EISSN: 1600-051X</identifier><identifier>DOI: 10.1111/jcpe.13514</identifier><identifier>PMID: 34189757</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>antibiotic prophylaxis ; Antibiotics ; Back surgery ; Dentistry ; Diagnosis, Epidemiology and Associated Co‐morbidities ; Disease prevention ; Infections ; invasive dental procedure ; nationwide database ; Original ; Patients ; Postoperative infection ; postoperative spinal infection ; Prophylaxis ; Risk factors ; spinal surgery ; Surgery</subject><ispartof>Journal of clinical periodontology, 2021-09, Vol.48 (9), p.1270-1280</ispartof><rights>2021 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4254-d8410a9d32ad2135a355a9824c4623ea223779f9985a4217237e5478af392e003</citedby><cites>FETCH-LOGICAL-c4254-d8410a9d32ad2135a355a9824c4623ea223779f9985a4217237e5478af392e003</cites><orcidid>0000-0003-1276-5978 ; 0000-0001-7235-4981</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjcpe.13514$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjcpe.13514$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Sung, Sahyun</creatorcontrib><creatorcontrib>Kim, Eun Hwa</creatorcontrib><creatorcontrib>Kwon, Ji‐Won</creatorcontrib><creatorcontrib>Lee, Jung‐Seok</creatorcontrib><creatorcontrib>Lee, Soo‐Bin</creatorcontrib><creatorcontrib>Moon, Seong‐Hwan</creatorcontrib><creatorcontrib>Lee, Hwan‐Mo</creatorcontrib><creatorcontrib>Jung, Inkyung</creatorcontrib><creatorcontrib>Lee, Byung Ho</creatorcontrib><title>Invasive dental procedures as risk factors for postoperative spinal infection and the effect of antibiotic prophylaxis</title><title>Journal of clinical periodontology</title><description>Aim
To identify invasive dental procedures as a risk factor for postoperative spinal infection (PSI) and evaluate the effectiveness of antibiotic prophylaxis.
Materials and Methods
We analysed 229,335 patients who underwent spinal surgery with instrumentation from 2010 to 2017, using the nationwide database. The incidence of spinal infection 2 years after surgery was determined. Invasive dental procedures as a risk factor for PSI and the effects of antibiotic prophylaxis during this period were also analysed.
Results
A total of 15,346 patients (6.69%) were diagnosed with PSI. It was found that advanced age, male sex, and a high Charlson Comorbidity Index were risk factors for PSI. The risk of PSI did not increase following dental procedures (adjusted hazard ratio [HR] 0.850; 95% confidence interval [CI], 0.793–0.912) and was not affected by antibiotics (adjusted HR 1.097; 95% CI, 0.987–1.218). Patients who received dental treatment as early as 3 months after spinal surgery had the lowest risk of postoperative infection (adjusted HR 0.869; 95% CI, 0.795–0.950).
Conclusions
Invasive dental procedure does not increase the risk of PSI, and antibiotic prophylaxis before dental procedure was not effective in preventing spinal infection.</description><subject>antibiotic prophylaxis</subject><subject>Antibiotics</subject><subject>Back surgery</subject><subject>Dentistry</subject><subject>Diagnosis, Epidemiology and Associated Co‐morbidities</subject><subject>Disease prevention</subject><subject>Infections</subject><subject>invasive dental procedure</subject><subject>nationwide database</subject><subject>Original</subject><subject>Patients</subject><subject>Postoperative infection</subject><subject>postoperative spinal infection</subject><subject>Prophylaxis</subject><subject>Risk factors</subject><subject>spinal surgery</subject><subject>Surgery</subject><issn>0303-6979</issn><issn>1600-051X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp9kU9v1DAQxS0EotvChU9giQtCSvG_xPEFCa0KLaoEB5C4WVNnwnrJxsF2tt1vj8NWSO0BXyyPf-9pZh4hrzg75-W827oJz7msuXpCVrxhrGI1__GUrJhksmqMNifkNKUtY1xLKZ-TE6l4a3StV2R_Ne4h-T3SDscMA51icNjNEROFRKNPv2gPLoeYaB8inULKYcIIedGkyY9F48ceXfZhpDB2NG-QYr9UaOhLJfsbH7J3i_W0OQxw59ML8qyHIeHL-_uMfP948W19WV1_-XS1_nBdOSVqVXWt4gxMJwV0okwIsq7BtEI51QiJIITU2vTGtDUowXV5Yq10C700AhmTZ-T90Xeab3bYuTJjhMFO0e8gHmwAbx_-jH5jf4a9bVWtmdHF4M29QQy_Z0zZ7nxyOAwwYpiTLV0uC1bMFPT1I3Qb5lj2s1CNYKaRcqHeHikXQ0oR-3_NcGaXOO0Sp_0bZ4H5Eb71Ax7-Q9rP668XR80fKAmiaQ</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Sung, Sahyun</creator><creator>Kim, Eun Hwa</creator><creator>Kwon, Ji‐Won</creator><creator>Lee, Jung‐Seok</creator><creator>Lee, Soo‐Bin</creator><creator>Moon, Seong‐Hwan</creator><creator>Lee, Hwan‐Mo</creator><creator>Jung, Inkyung</creator><creator>Lee, Byung Ho</creator><general>Blackwell Publishing Ltd</general><scope>24P</scope><scope>WIN</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1276-5978</orcidid><orcidid>https://orcid.org/0000-0001-7235-4981</orcidid></search><sort><creationdate>202109</creationdate><title>Invasive dental procedures as risk factors for postoperative spinal infection and the effect of antibiotic prophylaxis</title><author>Sung, Sahyun ; Kim, Eun Hwa ; Kwon, Ji‐Won ; Lee, Jung‐Seok ; Lee, Soo‐Bin ; Moon, Seong‐Hwan ; Lee, Hwan‐Mo ; Jung, Inkyung ; Lee, Byung Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4254-d8410a9d32ad2135a355a9824c4623ea223779f9985a4217237e5478af392e003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>antibiotic prophylaxis</topic><topic>Antibiotics</topic><topic>Back surgery</topic><topic>Dentistry</topic><topic>Diagnosis, Epidemiology and Associated Co‐morbidities</topic><topic>Disease prevention</topic><topic>Infections</topic><topic>invasive dental procedure</topic><topic>nationwide database</topic><topic>Original</topic><topic>Patients</topic><topic>Postoperative infection</topic><topic>postoperative spinal infection</topic><topic>Prophylaxis</topic><topic>Risk factors</topic><topic>spinal surgery</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sung, Sahyun</creatorcontrib><creatorcontrib>Kim, Eun Hwa</creatorcontrib><creatorcontrib>Kwon, Ji‐Won</creatorcontrib><creatorcontrib>Lee, Jung‐Seok</creatorcontrib><creatorcontrib>Lee, Soo‐Bin</creatorcontrib><creatorcontrib>Moon, Seong‐Hwan</creatorcontrib><creatorcontrib>Lee, Hwan‐Mo</creatorcontrib><creatorcontrib>Jung, Inkyung</creatorcontrib><creatorcontrib>Lee, Byung Ho</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical periodontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sung, Sahyun</au><au>Kim, Eun Hwa</au><au>Kwon, Ji‐Won</au><au>Lee, Jung‐Seok</au><au>Lee, Soo‐Bin</au><au>Moon, Seong‐Hwan</au><au>Lee, Hwan‐Mo</au><au>Jung, Inkyung</au><au>Lee, Byung Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Invasive dental procedures as risk factors for postoperative spinal infection and the effect of antibiotic prophylaxis</atitle><jtitle>Journal of clinical periodontology</jtitle><date>2021-09</date><risdate>2021</risdate><volume>48</volume><issue>9</issue><spage>1270</spage><epage>1280</epage><pages>1270-1280</pages><issn>0303-6979</issn><eissn>1600-051X</eissn><abstract>Aim
To identify invasive dental procedures as a risk factor for postoperative spinal infection (PSI) and evaluate the effectiveness of antibiotic prophylaxis.
Materials and Methods
We analysed 229,335 patients who underwent spinal surgery with instrumentation from 2010 to 2017, using the nationwide database. The incidence of spinal infection 2 years after surgery was determined. Invasive dental procedures as a risk factor for PSI and the effects of antibiotic prophylaxis during this period were also analysed.
Results
A total of 15,346 patients (6.69%) were diagnosed with PSI. It was found that advanced age, male sex, and a high Charlson Comorbidity Index were risk factors for PSI. The risk of PSI did not increase following dental procedures (adjusted hazard ratio [HR] 0.850; 95% confidence interval [CI], 0.793–0.912) and was not affected by antibiotics (adjusted HR 1.097; 95% CI, 0.987–1.218). Patients who received dental treatment as early as 3 months after spinal surgery had the lowest risk of postoperative infection (adjusted HR 0.869; 95% CI, 0.795–0.950).
Conclusions
Invasive dental procedure does not increase the risk of PSI, and antibiotic prophylaxis before dental procedure was not effective in preventing spinal infection.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>34189757</pmid><doi>10.1111/jcpe.13514</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-1276-5978</orcidid><orcidid>https://orcid.org/0000-0001-7235-4981</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | antibiotic prophylaxis Antibiotics Back surgery Dentistry Diagnosis, Epidemiology and Associated Co‐morbidities Disease prevention Infections invasive dental procedure nationwide database Original Patients Postoperative infection postoperative spinal infection Prophylaxis Risk factors spinal surgery Surgery |
| title | Invasive dental procedures as risk factors for postoperative spinal infection and the effect of antibiotic prophylaxis |
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