The Binding Pocket at the Interface of Multimeric Telomere G‐quadruplexes: Myth or Reality?

Human telomeric DNA with hundreds of repeats of the 5’‐TTAGGG‐3’ motif plays a crucial role in several biological processes. It folds into G‐quadruplex (G4) structures and features a pocket at the interface of two contiguous G4 blocks. Up to now no structural NMR and crystallographic data are availa...

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Veröffentlicht in:	Chemistry : a European journal 2021-08, Vol.27 (45), p.11707-11720
Hauptverfasser:	Manoli, Francesco, Doria, Filippo, Colombo, Giorgio, Zambelli, Barbara, Freccero, Mauro, Manet, Ilse
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Biological activity Calorimetry Chemistry Circular dichroism Crystallography Deoxyribonucleic acid Dichroism Diimide Dimers DNA Fluorescence Fluorescence Lifetime and Multiwavelength Global Analysis Human Telomeric DNA Isothermal Titration Calorimetry Ligands Molecular modelling Monomers Multimeric G-quadruplexes Naphthalene Naphthalene diimide dyads NMR Nuclear magnetic resonance Occupancy Stoichiometry Telomeres Titration Titration calorimetry
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