Asymmetric Synthesis of 2‐Arylindolines and 2,2‐Disubstituted Indolines by Kinetic Resolution

Kinetic resolution of 2‐arylindolines (2,3‐dihydroindoles) was achieved by treatment of their N‐tert‐butoxycarbonyl (Boc) derivatives with n‐butyllithium and sparteine in toluene at −78 °C followed by electrophilic quench. The unreacted starting materials together with the 2,2‐disubstituted products...

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Veröffentlicht in:	Chemistry : a European journal 2021-08, Vol.27 (45), p.11670-11675
Hauptverfasser:	Choi, Anthony, El‐Tunsi, Ashraf, Wang, Yuhang, Meijer, Anthony J. H. M., Li, Jia, Li, Xiabing, Proietti Silvestri, Ilaria, Coldham, Iain
Format:	Artikel
Sprache:	eng
Schlagworte:	Asymmetric synthesis Butyllithium Chemistry Enantiomers enantioselectivity heterocycles Heterocyclic compounds Indoles kinetic resolution Kinetics lithiation Magnetic resonance spectroscopy NMR NMR spectroscopy Nuclear magnetic resonance Selectivity Sparteine Spectroscopy Spectrum analysis Stereoisomerism Toluene
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