Sexual identity differences in biomarkers of tobacco exposure among women in a national sample
•Sexual minority compared to heterosexual women had higher levels of nicotine exposure.•Sexual minority compared to heterosexual women had higher levels of TSNAs.•Sexual identity differences varied by tobacco subgroup examined. Sexual minority women are consistently at increased risk for tobacco use...
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| Veröffentlicht in: | Cancer epidemiology 2021-10, Vol.74, p.101980-101980, Article 101980 |
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| container_title | Cancer epidemiology |
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| creator | Evans-Polce, Rebecca J. Smith, Danielle M. Veliz, Philip Boyd, Carol J. McCabe, Sean Esteban |
| description | •Sexual minority compared to heterosexual women had higher levels of nicotine exposure.•Sexual minority compared to heterosexual women had higher levels of TSNAs.•Sexual identity differences varied by tobacco subgroup examined.
Sexual minority women are consistently at increased risk for tobacco use compared to heterosexual women. Neither biomarkers of nicotine exposure nor biomarkers of tobacco toxicant exposure have been examined by sexual identity.
This study used interview and biomarker data from women in the biomarker core sample of Wave 1 of the Population Assessment of Tobacco and Health (PATH) study (2013–2014; n = 4930). We examined associations of sexual identity with nicotine exposure (measured with urinary cotinine and TNE-2) and with tobacco-specific nitrosamines (measured with urinary NNAL). Multivariable regression modeling was used to examine these associations among the full biomarker core sample, among past 30-day tobacco users, and among exclusive established cigarette users before and after controlling for tobacco use quantity and intensity.
In the full biomarker sample of women, prior to adjusting for tobacco use quantity and intensity, bisexual women had significantly higher cotinine, TNE-2, and NNAL levels compared to heterosexual women. Among exclusive established cigarette users, gay/lesbian women had significantly higher NNAL compared to heterosexual women prior to adjusting for tobacco quantity and intensity. No differences by sexual identity were found after adjusting for tobacco use quantity and intensity.
This is the first study to demonstrate differences in biological markers of tobacco exposure by sexual identity among women in the U.S. This has important public health implications as greater exposure to both nicotine and to tobacco-specific nitrosamines are strongly linked to cancer risk. |
| doi_str_mv | 10.1016/j.canep.2021.101980 |
| format | Article |
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Sexual minority women are consistently at increased risk for tobacco use compared to heterosexual women. Neither biomarkers of nicotine exposure nor biomarkers of tobacco toxicant exposure have been examined by sexual identity.
This study used interview and biomarker data from women in the biomarker core sample of Wave 1 of the Population Assessment of Tobacco and Health (PATH) study (2013–2014; n = 4930). We examined associations of sexual identity with nicotine exposure (measured with urinary cotinine and TNE-2) and with tobacco-specific nitrosamines (measured with urinary NNAL). Multivariable regression modeling was used to examine these associations among the full biomarker core sample, among past 30-day tobacco users, and among exclusive established cigarette users before and after controlling for tobacco use quantity and intensity.
In the full biomarker sample of women, prior to adjusting for tobacco use quantity and intensity, bisexual women had significantly higher cotinine, TNE-2, and NNAL levels compared to heterosexual women. Among exclusive established cigarette users, gay/lesbian women had significantly higher NNAL compared to heterosexual women prior to adjusting for tobacco quantity and intensity. No differences by sexual identity were found after adjusting for tobacco use quantity and intensity.
This is the first study to demonstrate differences in biological markers of tobacco exposure by sexual identity among women in the U.S. This has important public health implications as greater exposure to both nicotine and to tobacco-specific nitrosamines are strongly linked to cancer risk.</description><identifier>ISSN: 1877-7821</identifier><identifier>ISSN: 1877-783X</identifier><identifier>EISSN: 1877-783X</identifier><identifier>DOI: 10.1016/j.canep.2021.101980</identifier><identifier>PMID: 34247064</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adults ; Biomarkers ; Biomarkers of exposure ; Bisexuality ; Cancer ; Cigarettes ; Cotinine ; Creatinine ; Epidemiology ; Exposure ; Gays & lesbians ; Health care ; Health disparities ; Health risk assessment ; Health risks ; Humans ; Laboratories ; Minority & ethnic groups ; Nicotine ; Nicotine - adverse effects ; Nitrosamines ; Population ; Public health ; Response rates ; Sexual identity ; Smoking ; Tobacco ; Tobacco Products ; Tobacco use ; Toxicants ; Urine ; Womens health ; Women’s health</subject><ispartof>Cancer epidemiology, 2021-10, Vol.74, p.101980-101980, Article 101980</ispartof><rights>2021 Elsevier Ltd</rights><rights>Copyright © 2021 Elsevier Ltd. All rights reserved.</rights><rights>2021. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c437t-8fe1ed8c4b36de9165d65bb523d4cf3f39a1c8fe2c12b6ef36d457473c8d1ca83</cites><orcidid>0000-0002-9622-4652 ; 0000-0003-1848-4018</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2573420670?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,777,781,882,3537,27905,27906,45976,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34247064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Evans-Polce, Rebecca J.</creatorcontrib><creatorcontrib>Smith, Danielle M.</creatorcontrib><creatorcontrib>Veliz, Philip</creatorcontrib><creatorcontrib>Boyd, Carol J.</creatorcontrib><creatorcontrib>McCabe, Sean Esteban</creatorcontrib><title>Sexual identity differences in biomarkers of tobacco exposure among women in a national sample</title><title>Cancer epidemiology</title><addtitle>Cancer Epidemiol</addtitle><description>•Sexual minority compared to heterosexual women had higher levels of nicotine exposure.•Sexual minority compared to heterosexual women had higher levels of TSNAs.•Sexual identity differences varied by tobacco subgroup examined.
Sexual minority women are consistently at increased risk for tobacco use compared to heterosexual women. Neither biomarkers of nicotine exposure nor biomarkers of tobacco toxicant exposure have been examined by sexual identity.
This study used interview and biomarker data from women in the biomarker core sample of Wave 1 of the Population Assessment of Tobacco and Health (PATH) study (2013–2014; n = 4930). We examined associations of sexual identity with nicotine exposure (measured with urinary cotinine and TNE-2) and with tobacco-specific nitrosamines (measured with urinary NNAL). Multivariable regression modeling was used to examine these associations among the full biomarker core sample, among past 30-day tobacco users, and among exclusive established cigarette users before and after controlling for tobacco use quantity and intensity.
In the full biomarker sample of women, prior to adjusting for tobacco use quantity and intensity, bisexual women had significantly higher cotinine, TNE-2, and NNAL levels compared to heterosexual women. Among exclusive established cigarette users, gay/lesbian women had significantly higher NNAL compared to heterosexual women prior to adjusting for tobacco quantity and intensity. No differences by sexual identity were found after adjusting for tobacco use quantity and intensity.
This is the first study to demonstrate differences in biological markers of tobacco exposure by sexual identity among women in the U.S. This has important public health implications as greater exposure to both nicotine and to tobacco-specific nitrosamines are strongly linked to cancer risk.</description><subject>Adults</subject><subject>Biomarkers</subject><subject>Biomarkers of exposure</subject><subject>Bisexuality</subject><subject>Cancer</subject><subject>Cigarettes</subject><subject>Cotinine</subject><subject>Creatinine</subject><subject>Epidemiology</subject><subject>Exposure</subject><subject>Gays & lesbians</subject><subject>Health care</subject><subject>Health disparities</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Minority & ethnic groups</subject><subject>Nicotine</subject><subject>Nicotine - adverse effects</subject><subject>Nitrosamines</subject><subject>Population</subject><subject>Public health</subject><subject>Response rates</subject><subject>Sexual identity</subject><subject>Smoking</subject><subject>Tobacco</subject><subject>Tobacco Products</subject><subject>Tobacco use</subject><subject>Toxicants</subject><subject>Urine</subject><subject>Womens health</subject><subject>Women’s health</subject><issn>1877-7821</issn><issn>1877-783X</issn><issn>1877-783X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU9rFTEUxYNYbK1-AkECbty81_zPvIVCKVqFgosquDJkkpua58xkTGZq--3N9NWHuugqIfndc-89B6EXlKwpoepku3Z2gHHNCKPLy6Yhj9ARbbRe6YZ_fby_M3qInpayJUQpSuUTdMgFE5oocYS-XcLNbDscPQxTnG6xjyFAhsFBwXHAbUy9zT8gF5wCnlJrnUsYbsZU5gzY9mm4wr9SD8NCWzzYKaahChbbjx08QwfBdgWe35_H6Mv7d5_PPqwuPp1_PDu9WDnB9bRqAlDwjRMtVx42VEmvZNtKxr1wgQe-sdRViDnKWgWhUkJqoblrPHW24cfo7U53nNsevKvLZNuZMcc6_a1JNpp_f4b43Vyla9MIKasZVeD1vUBOP2cok-ljcdB11eI0F8OkJIpthFjQV_-h2zTnuvNC6WotUZpUiu8ol1MpGcJ-GErMkp_Zmrv8zJKf2eVXq17-vce-5k9gFXizA6C6eR0hm-LikpaPGdxkfIoPNvgNW1iu_Q</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Evans-Polce, Rebecca J.</creator><creator>Smith, Danielle M.</creator><creator>Veliz, Philip</creator><creator>Boyd, Carol J.</creator><creator>McCabe, Sean Esteban</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9622-4652</orcidid><orcidid>https://orcid.org/0000-0003-1848-4018</orcidid></search><sort><creationdate>20211001</creationdate><title>Sexual identity differences in biomarkers of tobacco exposure among women in a national sample</title><author>Evans-Polce, Rebecca J. ; Smith, Danielle M. ; Veliz, Philip ; Boyd, Carol J. ; McCabe, Sean Esteban</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-8fe1ed8c4b36de9165d65bb523d4cf3f39a1c8fe2c12b6ef36d457473c8d1ca83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adults</topic><topic>Biomarkers</topic><topic>Biomarkers of exposure</topic><topic>Bisexuality</topic><topic>Cancer</topic><topic>Cigarettes</topic><topic>Cotinine</topic><topic>Creatinine</topic><topic>Epidemiology</topic><topic>Exposure</topic><topic>Gays & lesbians</topic><topic>Health care</topic><topic>Health disparities</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Humans</topic><topic>Laboratories</topic><topic>Minority & ethnic groups</topic><topic>Nicotine</topic><topic>Nicotine - adverse effects</topic><topic>Nitrosamines</topic><topic>Population</topic><topic>Public health</topic><topic>Response rates</topic><topic>Sexual identity</topic><topic>Smoking</topic><topic>Tobacco</topic><topic>Tobacco Products</topic><topic>Tobacco use</topic><topic>Toxicants</topic><topic>Urine</topic><topic>Womens health</topic><topic>Women’s health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Evans-Polce, Rebecca J.</creatorcontrib><creatorcontrib>Smith, Danielle M.</creatorcontrib><creatorcontrib>Veliz, Philip</creatorcontrib><creatorcontrib>Boyd, Carol J.</creatorcontrib><creatorcontrib>McCabe, Sean Esteban</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Evans-Polce, Rebecca J.</au><au>Smith, Danielle M.</au><au>Veliz, Philip</au><au>Boyd, Carol J.</au><au>McCabe, Sean Esteban</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sexual identity differences in biomarkers of tobacco exposure among women in a national sample</atitle><jtitle>Cancer epidemiology</jtitle><addtitle>Cancer Epidemiol</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>74</volume><spage>101980</spage><epage>101980</epage><pages>101980-101980</pages><artnum>101980</artnum><issn>1877-7821</issn><issn>1877-783X</issn><eissn>1877-783X</eissn><abstract>•Sexual minority compared to heterosexual women had higher levels of nicotine exposure.•Sexual minority compared to heterosexual women had higher levels of TSNAs.•Sexual identity differences varied by tobacco subgroup examined.
Sexual minority women are consistently at increased risk for tobacco use compared to heterosexual women. Neither biomarkers of nicotine exposure nor biomarkers of tobacco toxicant exposure have been examined by sexual identity.
This study used interview and biomarker data from women in the biomarker core sample of Wave 1 of the Population Assessment of Tobacco and Health (PATH) study (2013–2014; n = 4930). We examined associations of sexual identity with nicotine exposure (measured with urinary cotinine and TNE-2) and with tobacco-specific nitrosamines (measured with urinary NNAL). Multivariable regression modeling was used to examine these associations among the full biomarker core sample, among past 30-day tobacco users, and among exclusive established cigarette users before and after controlling for tobacco use quantity and intensity.
In the full biomarker sample of women, prior to adjusting for tobacco use quantity and intensity, bisexual women had significantly higher cotinine, TNE-2, and NNAL levels compared to heterosexual women. Among exclusive established cigarette users, gay/lesbian women had significantly higher NNAL compared to heterosexual women prior to adjusting for tobacco quantity and intensity. No differences by sexual identity were found after adjusting for tobacco use quantity and intensity.
This is the first study to demonstrate differences in biological markers of tobacco exposure by sexual identity among women in the U.S. This has important public health implications as greater exposure to both nicotine and to tobacco-specific nitrosamines are strongly linked to cancer risk.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>34247064</pmid><doi>10.1016/j.canep.2021.101980</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-9622-4652</orcidid><orcidid>https://orcid.org/0000-0003-1848-4018</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adults Biomarkers Biomarkers of exposure Bisexuality Cancer Cigarettes Cotinine Creatinine Epidemiology Exposure Gays & lesbians Health care Health disparities Health risk assessment Health risks Humans Laboratories Minority & ethnic groups Nicotine Nicotine - adverse effects Nitrosamines Population Public health Response rates Sexual identity Smoking Tobacco Tobacco Products Tobacco use Toxicants Urine Womens health Women’s health |
| title | Sexual identity differences in biomarkers of tobacco exposure among women in a national sample |
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