Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy Outcomes in a U.S. Population
To examine whether the coronavirus disease 2019 (COVID-19) pandemic altered risk of adverse pregnancy-related outcomes and whether there were differences by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection status among pregnant women. In this retrospective cohort study using Ep...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 2021-10, Vol.138 (4), p.542-551 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
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| creator | Son, Moeun Gallagher, Kieran Lo, Justin Y. Lindgren, Eric Burris, Heather H. Dysart, Kevin Greenspan, Jay Culhane, Jennifer F. Handley, Sara C. |
| description | To examine whether the coronavirus disease 2019 (COVID-19) pandemic altered risk of adverse pregnancy-related outcomes and whether there were differences by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection status among pregnant women.
In this retrospective cohort study using Epic's Cosmos research platform, women who delivered during the pandemic (March-December 2020) were compared with those who delivered prepandemic (matched months 2017-2019). Within the pandemic epoch, those who tested positive for SARS-CoV-2 infection were compared with those with negative test results or no SARS-CoV-2 diagnosis. Comparisons were performed using standardized differences, with a value greater than 0.1 indicating meaningful differences between groups.
Among 838,489 women (225,225 who delivered during the pandemic), baseline characteristics were similar between epochs. There were no significant differences in adverse pregnancy outcomes between epochs (standardized difference |
| doi_str_mv | 10.1097/AOG.0000000000004547 |
| format | Article |
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In this retrospective cohort study using Epic's Cosmos research platform, women who delivered during the pandemic (March-December 2020) were compared with those who delivered prepandemic (matched months 2017-2019). Within the pandemic epoch, those who tested positive for SARS-CoV-2 infection were compared with those with negative test results or no SARS-CoV-2 diagnosis. Comparisons were performed using standardized differences, with a value greater than 0.1 indicating meaningful differences between groups.
Among 838,489 women (225,225 who delivered during the pandemic), baseline characteristics were similar between epochs. There were no significant differences in adverse pregnancy outcomes between epochs (standardized difference<0.10). In the pandemic epoch, 108,067 (48.0%) women had SARS-CoV-2 testing available; of those, 7,432 (6.9%) had positive test results. Compared with women classified as negative for SARS-CoV-2 infection, those who tested positive for SARS-CoV-2 infection were less likely to be non-Hispanic White or Asian or to reside in the Midwest and more likely to be Hispanic, have public insurance, be obese, and reside in the South or in high social vulnerability ZIP codes. There were no significant differences in the frequency of preterm birth (8.5% vs 7.6%, standardized difference=0.032), stillbirth (0.4% vs 0.4%, standardized difference=-0.002), small for gestational age (6.4% vs 6.5%, standardized difference=-0.002), large for gestational age (7.7% vs 7.7%, standardized difference=-0.001), hypertensive disorders of pregnancy (16.3% vs 15.8%, standardized difference=0.014), placental abruption (0.5% vs 0.4%, standardized difference=0.007), cesarean birth (31.2% vs 29.4%, standardized difference=0.039), or postpartum hemorrhage (3.4% vs 3.1%, standardized difference=0.019) between those who tested positive for SARS-CoV-2 infection and those classified as testing negative.
In a geographically diverse U.S. cohort, the frequency of adverse pregnancy-related outcomes did not differ between those delivering before compared with during the pandemic, nor between those classified as positive compared with negative for SARS-CoV-2 infection during pregnancy.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>DOI: 10.1097/AOG.0000000000004547</identifier><identifier>PMID: 34433180</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Adult ; Contents ; COVID-19 - complications ; COVID-19 - epidemiology ; COVID-19 Testing - statistics & numerical data ; Female ; Humans ; Infant, Newborn ; Original Research ; Pregnancy ; Pregnancy Complications, Infectious - epidemiology ; Pregnancy Complications, Infectious - virology ; Pregnancy Outcome - epidemiology ; Prenatal Care - statistics & numerical data ; Retrospective Studies ; SARS-CoV-2 ; United States - epidemiology</subject><ispartof>Obstetrics and gynecology (New York. 1953), 2021-10, Vol.138 (4), p.542-551</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2021 by the American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.</rights><rights>2021 by the American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4534-f96509c4455ee680471ad65a4ed84a5caf854498154830d94146cce6454f2ee13</citedby><cites>FETCH-LOGICAL-c4534-f96509c4455ee680471ad65a4ed84a5caf854498154830d94146cce6454f2ee13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34433180$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Son, Moeun</creatorcontrib><creatorcontrib>Gallagher, Kieran</creatorcontrib><creatorcontrib>Lo, Justin Y.</creatorcontrib><creatorcontrib>Lindgren, Eric</creatorcontrib><creatorcontrib>Burris, Heather H.</creatorcontrib><creatorcontrib>Dysart, Kevin</creatorcontrib><creatorcontrib>Greenspan, Jay</creatorcontrib><creatorcontrib>Culhane, Jennifer F.</creatorcontrib><creatorcontrib>Handley, Sara C.</creatorcontrib><title>Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy Outcomes in a U.S. Population</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>To examine whether the coronavirus disease 2019 (COVID-19) pandemic altered risk of adverse pregnancy-related outcomes and whether there were differences by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection status among pregnant women.
In this retrospective cohort study using Epic's Cosmos research platform, women who delivered during the pandemic (March-December 2020) were compared with those who delivered prepandemic (matched months 2017-2019). Within the pandemic epoch, those who tested positive for SARS-CoV-2 infection were compared with those with negative test results or no SARS-CoV-2 diagnosis. Comparisons were performed using standardized differences, with a value greater than 0.1 indicating meaningful differences between groups.
Among 838,489 women (225,225 who delivered during the pandemic), baseline characteristics were similar between epochs. There were no significant differences in adverse pregnancy outcomes between epochs (standardized difference<0.10). In the pandemic epoch, 108,067 (48.0%) women had SARS-CoV-2 testing available; of those, 7,432 (6.9%) had positive test results. Compared with women classified as negative for SARS-CoV-2 infection, those who tested positive for SARS-CoV-2 infection were less likely to be non-Hispanic White or Asian or to reside in the Midwest and more likely to be Hispanic, have public insurance, be obese, and reside in the South or in high social vulnerability ZIP codes. There were no significant differences in the frequency of preterm birth (8.5% vs 7.6%, standardized difference=0.032), stillbirth (0.4% vs 0.4%, standardized difference=-0.002), small for gestational age (6.4% vs 6.5%, standardized difference=-0.002), large for gestational age (7.7% vs 7.7%, standardized difference=-0.001), hypertensive disorders of pregnancy (16.3% vs 15.8%, standardized difference=0.014), placental abruption (0.5% vs 0.4%, standardized difference=0.007), cesarean birth (31.2% vs 29.4%, standardized difference=0.039), or postpartum hemorrhage (3.4% vs 3.1%, standardized difference=0.019) between those who tested positive for SARS-CoV-2 infection and those classified as testing negative.
In a geographically diverse U.S. cohort, the frequency of adverse pregnancy-related outcomes did not differ between those delivering before compared with during the pandemic, nor between those classified as positive compared with negative for SARS-CoV-2 infection during pregnancy.</description><subject>Adult</subject><subject>Contents</subject><subject>COVID-19 - complications</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 Testing - statistics & numerical data</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Original Research</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - epidemiology</subject><subject>Pregnancy Complications, Infectious - virology</subject><subject>Pregnancy Outcome - epidemiology</subject><subject>Prenatal Care - statistics & numerical data</subject><subject>Retrospective Studies</subject><subject>SARS-CoV-2</subject><subject>United States - epidemiology</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1v1DAQhi0EokvhHyDkYzlk8cc4sS9I1RZKpUq7EhT1Zhln0g0k9tZOWvXfY-hSCr7Mwe88M6OHkNecLTkzzbvj9emSPXqgoHlCFlw3shJSXj4lC8aEqRoNcEBe5Py9hHht5HNyIAGk5JotyOUqphjcTZ_mTE_6jC4jFYwberRafz07qbh5SzcutDj2npZKNwmvggv-jq7nyccRM-0DdfRi-XlJN3E3D27qY3hJnnVuyPhqXw_JxccPX1afqvP16dnq-LzyoCRUnakVMx5AKcRaM2i4a2vlAFsNTnnXaQVgNFegJWsNcKi9x7pc2wlELg_J-3vubv42YusxTMkNdpf60aU7G11v__0J_dZexRurC0JoUQBHe0CK1zPmyY599jgMLmCcsxWqBqOkMKxE4T7qU8w5YfcwhjP7S4otUuz_Ukrbm8crPjT9sfCXexuHCVP-Mcy3mOwW3TBtf_NqoVhlzJ5aFbENyJ-dkZSd</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Son, Moeun</creator><creator>Gallagher, Kieran</creator><creator>Lo, Justin Y.</creator><creator>Lindgren, Eric</creator><creator>Burris, Heather H.</creator><creator>Dysart, Kevin</creator><creator>Greenspan, Jay</creator><creator>Culhane, Jennifer F.</creator><creator>Handley, Sara C.</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211001</creationdate><title>Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy Outcomes in a U.S. Population</title><author>Son, Moeun ; Gallagher, Kieran ; Lo, Justin Y. ; Lindgren, Eric ; Burris, Heather H. ; Dysart, Kevin ; Greenspan, Jay ; Culhane, Jennifer F. ; Handley, Sara C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4534-f96509c4455ee680471ad65a4ed84a5caf854498154830d94146cce6454f2ee13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Contents</topic><topic>COVID-19 - complications</topic><topic>COVID-19 - epidemiology</topic><topic>COVID-19 Testing - statistics & numerical data</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Original Research</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - epidemiology</topic><topic>Pregnancy Complications, Infectious - virology</topic><topic>Pregnancy Outcome - epidemiology</topic><topic>Prenatal Care - statistics & numerical data</topic><topic>Retrospective Studies</topic><topic>SARS-CoV-2</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Son, Moeun</creatorcontrib><creatorcontrib>Gallagher, Kieran</creatorcontrib><creatorcontrib>Lo, Justin Y.</creatorcontrib><creatorcontrib>Lindgren, Eric</creatorcontrib><creatorcontrib>Burris, Heather H.</creatorcontrib><creatorcontrib>Dysart, Kevin</creatorcontrib><creatorcontrib>Greenspan, Jay</creatorcontrib><creatorcontrib>Culhane, Jennifer F.</creatorcontrib><creatorcontrib>Handley, Sara C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Son, Moeun</au><au>Gallagher, Kieran</au><au>Lo, Justin Y.</au><au>Lindgren, Eric</au><au>Burris, Heather H.</au><au>Dysart, Kevin</au><au>Greenspan, Jay</au><au>Culhane, Jennifer F.</au><au>Handley, Sara C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy Outcomes in a U.S. Population</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>138</volume><issue>4</issue><spage>542</spage><epage>551</epage><pages>542-551</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><abstract>To examine whether the coronavirus disease 2019 (COVID-19) pandemic altered risk of adverse pregnancy-related outcomes and whether there were differences by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection status among pregnant women.
In this retrospective cohort study using Epic's Cosmos research platform, women who delivered during the pandemic (March-December 2020) were compared with those who delivered prepandemic (matched months 2017-2019). Within the pandemic epoch, those who tested positive for SARS-CoV-2 infection were compared with those with negative test results or no SARS-CoV-2 diagnosis. Comparisons were performed using standardized differences, with a value greater than 0.1 indicating meaningful differences between groups.
Among 838,489 women (225,225 who delivered during the pandemic), baseline characteristics were similar between epochs. There were no significant differences in adverse pregnancy outcomes between epochs (standardized difference<0.10). In the pandemic epoch, 108,067 (48.0%) women had SARS-CoV-2 testing available; of those, 7,432 (6.9%) had positive test results. Compared with women classified as negative for SARS-CoV-2 infection, those who tested positive for SARS-CoV-2 infection were less likely to be non-Hispanic White or Asian or to reside in the Midwest and more likely to be Hispanic, have public insurance, be obese, and reside in the South or in high social vulnerability ZIP codes. There were no significant differences in the frequency of preterm birth (8.5% vs 7.6%, standardized difference=0.032), stillbirth (0.4% vs 0.4%, standardized difference=-0.002), small for gestational age (6.4% vs 6.5%, standardized difference=-0.002), large for gestational age (7.7% vs 7.7%, standardized difference=-0.001), hypertensive disorders of pregnancy (16.3% vs 15.8%, standardized difference=0.014), placental abruption (0.5% vs 0.4%, standardized difference=0.007), cesarean birth (31.2% vs 29.4%, standardized difference=0.039), or postpartum hemorrhage (3.4% vs 3.1%, standardized difference=0.019) between those who tested positive for SARS-CoV-2 infection and those classified as testing negative.
In a geographically diverse U.S. cohort, the frequency of adverse pregnancy-related outcomes did not differ between those delivering before compared with during the pandemic, nor between those classified as positive compared with negative for SARS-CoV-2 infection during pregnancy.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>34433180</pmid><doi>10.1097/AOG.0000000000004547</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0029-7844 |
| ispartof | Obstetrics and gynecology (New York. 1953), 2021-10, Vol.138 (4), p.542-551 |
| issn | 0029-7844 1873-233X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Adult Contents COVID-19 - complications COVID-19 - epidemiology COVID-19 Testing - statistics & numerical data Female Humans Infant, Newborn Original Research Pregnancy Pregnancy Complications, Infectious - epidemiology Pregnancy Complications, Infectious - virology Pregnancy Outcome - epidemiology Prenatal Care - statistics & numerical data Retrospective Studies SARS-CoV-2 United States - epidemiology |
| title | Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy Outcomes in a U.S. Population |
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