From Natural Methylation to Versatile Alkylations Using Halide Methyltransferases

Halide methyltransferases (HMTs) enable the enzymatic synthesis of S‐adenosyl‐l‐methionine (SAM) from S‐adenosyl‐l‐homocysteine (SAH) and methyl iodide. Characterisation of a range of naturally occurring HMTs and subsequent protein engineering led to HMT variants capable of synthesising ethyl, propy...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2021-08, Vol.22 (16), p.2584-2590
Hauptverfasser:	Tang, Qingyun, Pavlidis, Ioannis V., Badenhorst, Christoffel P. S., Bornscheuer, Uwe T.
Format:	Artikel
Sprache:	eng
Schlagworte:	alkyl iodide Alkylation Biocatalysis Chemical synthesis Concept Concepts Enzymatic synthesis halide methyltransferase Homocysteine Iodides Methionine Methylation Methyltransferases - chemistry Methyltransferases - metabolism Protein Engineering S-Adenosylmethionine - chemistry S-Adenosylmethionine - metabolism SAM analogue Substrates
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