Prevalence and early‐life risk factors of school‐age allergic multimorbidity: The EuroPrevall‐iFAAM birth cohort
Background Coexistence of childhood asthma, eczema and allergic rhinitis is higher than can be expected by chance, suggesting a common mechanism. Data on allergic multimorbidity from a pan‐European, population‐based birth cohort study have been lacking. This study compares the prevalence and early‐l...
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| Veröffentlicht in: | Allergy (Copenhagen) 2021-09, Vol.76 (9), p.2855-2865 |
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| creator | Sigurdardottir, Sigurveig T. Jonasson, Kristjan Clausen, Michael Lilja Bjornsdottir, Kristin Sigurdardottir, Sigridur Erla Roberts, Graham Grimshaw, Kate Papadopoulos, Nikolaos G. Xepapadaki, Paraskevi Fiandor, Ana Quirce, Santiago Sprikkelman, Aline B. Hulshof, Lies Kowalski, Marek L. Kurowski, Marcin Dubakiene, Ruta Rudzeviciene, Odilija Bellach, Johanna Yürek, Songül Reich, Andreas Erhard, Sina Maria Couch, Philip Rivas, Montserrat Fernandez van Ree, Ronald Mills, Clare Grabenhenrich, Linus Beyer, Kirsten Keil, Thomas |
| description | Background
Coexistence of childhood asthma, eczema and allergic rhinitis is higher than can be expected by chance, suggesting a common mechanism. Data on allergic multimorbidity from a pan‐European, population‐based birth cohort study have been lacking. This study compares the prevalence and early‐life risk factors of these diseases in European primary school children.
Methods
In the prospective multicentre observational EuroPrevall‐iFAAM birth cohort study, we used standardized questionnaires on sociodemographics, medical history, parental allergies and lifestyle, and environmental exposures at birth, 12 and 24 months. At primary school age, parents answered ISAAC‐based questions on current asthma, rhinitis and eczema. Allergic multimorbidity was defined as the coexistence of at least two of these.
Results
From 10,563 children recruited at birth in 8 study centres, we included data from 5,572 children (mean age 8.2 years; 51.8% boys). Prevalence estimates were as follows: asthma, 8.1%; allergic rhinitis, 13.3%; and eczema, 12.0%. Allergic multimorbidity was seen in 7.0% of the whole cohort, ranging from 1.2% (Athens, Greece) to 10.9% (Madrid, Spain). Risk factors for allergic multimorbidity, identified with AICc, included family‐allergy‐score, odds ratio (OR) 1.50 (95% CI 1.32–1.70) per standard deviation; early‐life allergy symptoms, OR 2.72 (2.34–3.16) for each symptom; and caesarean birth, OR 1.35 (1.04–1.76). Female gender, OR 0.72 (0.58–0.90); older siblings, OR 0.79 (0.63–0.99); and day care, OR 0.81 (0.63–1.06) were protective factors.
Conclusion
Allergic multimorbidity should be regarded as an important chronic childhood disease in Europe. Some of the associated early‐life factors are modifiable and may be considered for prevention strategies.
Allergic multimorbidity (coexistence of asthma, eczema and allergic rhinitis) is common among European children at primary school age, with 7% of study participants affected. Protective factors identified in the study include female sex, having older siblings and attending day care. Risk factors include history of allergic diseases in first‐degree family members, early‐age symptoms and caesarean birth. |
| doi_str_mv | 10.1111/all.14857 |
| format | Article |
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Coexistence of childhood asthma, eczema and allergic rhinitis is higher than can be expected by chance, suggesting a common mechanism. Data on allergic multimorbidity from a pan‐European, population‐based birth cohort study have been lacking. This study compares the prevalence and early‐life risk factors of these diseases in European primary school children.
Methods
In the prospective multicentre observational EuroPrevall‐iFAAM birth cohort study, we used standardized questionnaires on sociodemographics, medical history, parental allergies and lifestyle, and environmental exposures at birth, 12 and 24 months. At primary school age, parents answered ISAAC‐based questions on current asthma, rhinitis and eczema. Allergic multimorbidity was defined as the coexistence of at least two of these.
Results
From 10,563 children recruited at birth in 8 study centres, we included data from 5,572 children (mean age 8.2 years; 51.8% boys). Prevalence estimates were as follows: asthma, 8.1%; allergic rhinitis, 13.3%; and eczema, 12.0%. Allergic multimorbidity was seen in 7.0% of the whole cohort, ranging from 1.2% (Athens, Greece) to 10.9% (Madrid, Spain). Risk factors for allergic multimorbidity, identified with AICc, included family‐allergy‐score, odds ratio (OR) 1.50 (95% CI 1.32–1.70) per standard deviation; early‐life allergy symptoms, OR 2.72 (2.34–3.16) for each symptom; and caesarean birth, OR 1.35 (1.04–1.76). Female gender, OR 0.72 (0.58–0.90); older siblings, OR 0.79 (0.63–0.99); and day care, OR 0.81 (0.63–1.06) were protective factors.
Conclusion
Allergic multimorbidity should be regarded as an important chronic childhood disease in Europe. Some of the associated early‐life factors are modifiable and may be considered for prevention strategies.
Allergic multimorbidity (coexistence of asthma, eczema and allergic rhinitis) is common among European children at primary school age, with 7% of study participants affected. Protective factors identified in the study include female sex, having older siblings and attending day care. Risk factors include history of allergic diseases in first‐degree family members, early‐age symptoms and caesarean birth.</description><identifier>ISSN: 0105-4538</identifier><identifier>EISSN: 1398-9995</identifier><identifier>DOI: 10.1111/all.14857</identifier><identifier>PMID: 33934363</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Age ; allergic multimorbidity ; Allergic rhinitis ; Allergies ; Asthma ; Child ; Children ; Coexistence ; Cohort Studies ; Comorbidity ; Eczema ; Eczema - epidemiology ; Female ; Humans ; Hypersensitivity ; Infant, Newborn ; Male ; Multimorbidity ; Original ; ORIGINAL ARTICLES ; Population studies ; Pregnancy ; Prevalence ; Prospective Studies ; Rhinitis ; Rhinitis, Allergic - epidemiology ; Risk Factors ; Schools ; Surveys and Questionnaires</subject><ispartof>Allergy (Copenhagen), 2021-09, Vol.76 (9), p.2855-2865</ispartof><rights>2021 The Authors. published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.</rights><rights>2021 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4437-22d84d33840c47f71812f5375c14cc183f135b232aa6aaaaaf7561ca26da64253</citedby><cites>FETCH-LOGICAL-c4437-22d84d33840c47f71812f5375c14cc183f135b232aa6aaaaaf7561ca26da64253</cites><orcidid>0000-0002-9300-6625 ; 0000-0002-8442-2774 ; 0000-0002-4448-3468 ; 0000-0003-2252-1248 ; 0000-0002-6275-0910 ; 0000-0002-9066-3128 ; 0000-0001-9204-1923 ; 0000-0002-9108-3360</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fall.14857$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fall.14857$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33934363$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sigurdardottir, Sigurveig T.</creatorcontrib><creatorcontrib>Jonasson, Kristjan</creatorcontrib><creatorcontrib>Clausen, Michael</creatorcontrib><creatorcontrib>Lilja Bjornsdottir, Kristin</creatorcontrib><creatorcontrib>Sigurdardottir, Sigridur Erla</creatorcontrib><creatorcontrib>Roberts, Graham</creatorcontrib><creatorcontrib>Grimshaw, Kate</creatorcontrib><creatorcontrib>Papadopoulos, Nikolaos G.</creatorcontrib><creatorcontrib>Xepapadaki, Paraskevi</creatorcontrib><creatorcontrib>Fiandor, Ana</creatorcontrib><creatorcontrib>Quirce, Santiago</creatorcontrib><creatorcontrib>Sprikkelman, Aline B.</creatorcontrib><creatorcontrib>Hulshof, Lies</creatorcontrib><creatorcontrib>Kowalski, Marek L.</creatorcontrib><creatorcontrib>Kurowski, Marcin</creatorcontrib><creatorcontrib>Dubakiene, Ruta</creatorcontrib><creatorcontrib>Rudzeviciene, Odilija</creatorcontrib><creatorcontrib>Bellach, Johanna</creatorcontrib><creatorcontrib>Yürek, Songül</creatorcontrib><creatorcontrib>Reich, Andreas</creatorcontrib><creatorcontrib>Erhard, Sina Maria</creatorcontrib><creatorcontrib>Couch, Philip</creatorcontrib><creatorcontrib>Rivas, Montserrat Fernandez</creatorcontrib><creatorcontrib>van Ree, Ronald</creatorcontrib><creatorcontrib>Mills, Clare</creatorcontrib><creatorcontrib>Grabenhenrich, Linus</creatorcontrib><creatorcontrib>Beyer, Kirsten</creatorcontrib><creatorcontrib>Keil, Thomas</creatorcontrib><title>Prevalence and early‐life risk factors of school‐age allergic multimorbidity: The EuroPrevall‐iFAAM birth cohort</title><title>Allergy (Copenhagen)</title><addtitle>Allergy</addtitle><description>Background
Coexistence of childhood asthma, eczema and allergic rhinitis is higher than can be expected by chance, suggesting a common mechanism. Data on allergic multimorbidity from a pan‐European, population‐based birth cohort study have been lacking. This study compares the prevalence and early‐life risk factors of these diseases in European primary school children.
Methods
In the prospective multicentre observational EuroPrevall‐iFAAM birth cohort study, we used standardized questionnaires on sociodemographics, medical history, parental allergies and lifestyle, and environmental exposures at birth, 12 and 24 months. At primary school age, parents answered ISAAC‐based questions on current asthma, rhinitis and eczema. Allergic multimorbidity was defined as the coexistence of at least two of these.
Results
From 10,563 children recruited at birth in 8 study centres, we included data from 5,572 children (mean age 8.2 years; 51.8% boys). Prevalence estimates were as follows: asthma, 8.1%; allergic rhinitis, 13.3%; and eczema, 12.0%. Allergic multimorbidity was seen in 7.0% of the whole cohort, ranging from 1.2% (Athens, Greece) to 10.9% (Madrid, Spain). Risk factors for allergic multimorbidity, identified with AICc, included family‐allergy‐score, odds ratio (OR) 1.50 (95% CI 1.32–1.70) per standard deviation; early‐life allergy symptoms, OR 2.72 (2.34–3.16) for each symptom; and caesarean birth, OR 1.35 (1.04–1.76). Female gender, OR 0.72 (0.58–0.90); older siblings, OR 0.79 (0.63–0.99); and day care, OR 0.81 (0.63–1.06) were protective factors.
Conclusion
Allergic multimorbidity should be regarded as an important chronic childhood disease in Europe. Some of the associated early‐life factors are modifiable and may be considered for prevention strategies.
Allergic multimorbidity (coexistence of asthma, eczema and allergic rhinitis) is common among European children at primary school age, with 7% of study participants affected. Protective factors identified in the study include female sex, having older siblings and attending day care. Risk factors include history of allergic diseases in first‐degree family members, early‐age symptoms and caesarean birth.</description><subject>Age</subject><subject>allergic multimorbidity</subject><subject>Allergic rhinitis</subject><subject>Allergies</subject><subject>Asthma</subject><subject>Child</subject><subject>Children</subject><subject>Coexistence</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Eczema</subject><subject>Eczema - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypersensitivity</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Multimorbidity</subject><subject>Original</subject><subject>ORIGINAL ARTICLES</subject><subject>Population studies</subject><subject>Pregnancy</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Rhinitis</subject><subject>Rhinitis, Allergic - epidemiology</subject><subject>Risk Factors</subject><subject>Schools</subject><subject>Surveys and Questionnaires</subject><issn>0105-4538</issn><issn>1398-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kb9OHDEQh60oUbgQCl4AWUqVYsF_116KSCcEIdJFpIDa8nntW4NvTezdi67jEXjGPEl8LEFJwTRTzKdvRvMD4BCjY1zqRIdwjJnk4g2YYdrIqmka_hbMEEa8YpzKPfAh51uEkCANeg_2KG0oozWdgc2PZDc62N5YqPsWWp3C9vfDY_DOwuTzHXTaDDFlGB3MposxlKleFToEm1bewPUYBr-OaelbP2xP4XVn4fmY4mTe4f5iPv8Olz4NHTSxi2n4CN45HbI9eO774Obi_Prsslpcff12Nl9UhjEqKkJayVpKJUOGCSewxMRxKrjBzBgsqcOULwklWtd6V07wGhtN6lbXjHC6D75M3vtxubatsf2QdFD3ya912qqovfp_0vtOreJGSbZbI4rg07MgxZ-jzYO6jWPqy82K8FpIhCTFhfo8USbFnJN1LxswUruIVHmEeoqosEf_nvRC_s2kACcT8MsHu33dpOaLxaT8AycZn5k</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Sigurdardottir, Sigurveig T.</creator><creator>Jonasson, Kristjan</creator><creator>Clausen, Michael</creator><creator>Lilja Bjornsdottir, Kristin</creator><creator>Sigurdardottir, Sigridur Erla</creator><creator>Roberts, Graham</creator><creator>Grimshaw, Kate</creator><creator>Papadopoulos, Nikolaos G.</creator><creator>Xepapadaki, Paraskevi</creator><creator>Fiandor, Ana</creator><creator>Quirce, Santiago</creator><creator>Sprikkelman, Aline B.</creator><creator>Hulshof, Lies</creator><creator>Kowalski, Marek L.</creator><creator>Kurowski, Marcin</creator><creator>Dubakiene, Ruta</creator><creator>Rudzeviciene, Odilija</creator><creator>Bellach, Johanna</creator><creator>Yürek, Songül</creator><creator>Reich, Andreas</creator><creator>Erhard, Sina Maria</creator><creator>Couch, Philip</creator><creator>Rivas, Montserrat Fernandez</creator><creator>van Ree, Ronald</creator><creator>Mills, Clare</creator><creator>Grabenhenrich, Linus</creator><creator>Beyer, Kirsten</creator><creator>Keil, Thomas</creator><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9300-6625</orcidid><orcidid>https://orcid.org/0000-0002-8442-2774</orcidid><orcidid>https://orcid.org/0000-0002-4448-3468</orcidid><orcidid>https://orcid.org/0000-0003-2252-1248</orcidid><orcidid>https://orcid.org/0000-0002-6275-0910</orcidid><orcidid>https://orcid.org/0000-0002-9066-3128</orcidid><orcidid>https://orcid.org/0000-0001-9204-1923</orcidid><orcidid>https://orcid.org/0000-0002-9108-3360</orcidid></search><sort><creationdate>202109</creationdate><title>Prevalence and early‐life risk factors of school‐age allergic multimorbidity: The EuroPrevall‐iFAAM birth cohort</title><author>Sigurdardottir, Sigurveig T. ; Jonasson, Kristjan ; Clausen, Michael ; Lilja Bjornsdottir, Kristin ; Sigurdardottir, Sigridur Erla ; Roberts, Graham ; Grimshaw, Kate ; Papadopoulos, Nikolaos G. ; Xepapadaki, Paraskevi ; Fiandor, Ana ; Quirce, Santiago ; Sprikkelman, Aline B. ; Hulshof, Lies ; Kowalski, Marek L. ; Kurowski, Marcin ; Dubakiene, Ruta ; Rudzeviciene, Odilija ; Bellach, Johanna ; Yürek, Songül ; Reich, Andreas ; Erhard, Sina Maria ; Couch, Philip ; Rivas, Montserrat Fernandez ; van Ree, Ronald ; Mills, Clare ; Grabenhenrich, Linus ; Beyer, Kirsten ; Keil, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4437-22d84d33840c47f71812f5375c14cc183f135b232aa6aaaaaf7561ca26da64253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>allergic multimorbidity</topic><topic>Allergic rhinitis</topic><topic>Allergies</topic><topic>Asthma</topic><topic>Child</topic><topic>Children</topic><topic>Coexistence</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>Eczema</topic><topic>Eczema - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypersensitivity</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Multimorbidity</topic><topic>Original</topic><topic>ORIGINAL ARTICLES</topic><topic>Population studies</topic><topic>Pregnancy</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Rhinitis</topic><topic>Rhinitis, Allergic - epidemiology</topic><topic>Risk Factors</topic><topic>Schools</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sigurdardottir, Sigurveig T.</creatorcontrib><creatorcontrib>Jonasson, Kristjan</creatorcontrib><creatorcontrib>Clausen, Michael</creatorcontrib><creatorcontrib>Lilja Bjornsdottir, Kristin</creatorcontrib><creatorcontrib>Sigurdardottir, Sigridur Erla</creatorcontrib><creatorcontrib>Roberts, Graham</creatorcontrib><creatorcontrib>Grimshaw, Kate</creatorcontrib><creatorcontrib>Papadopoulos, Nikolaos G.</creatorcontrib><creatorcontrib>Xepapadaki, Paraskevi</creatorcontrib><creatorcontrib>Fiandor, Ana</creatorcontrib><creatorcontrib>Quirce, Santiago</creatorcontrib><creatorcontrib>Sprikkelman, Aline B.</creatorcontrib><creatorcontrib>Hulshof, Lies</creatorcontrib><creatorcontrib>Kowalski, Marek L.</creatorcontrib><creatorcontrib>Kurowski, Marcin</creatorcontrib><creatorcontrib>Dubakiene, Ruta</creatorcontrib><creatorcontrib>Rudzeviciene, Odilija</creatorcontrib><creatorcontrib>Bellach, Johanna</creatorcontrib><creatorcontrib>Yürek, Songül</creatorcontrib><creatorcontrib>Reich, Andreas</creatorcontrib><creatorcontrib>Erhard, Sina Maria</creatorcontrib><creatorcontrib>Couch, Philip</creatorcontrib><creatorcontrib>Rivas, Montserrat Fernandez</creatorcontrib><creatorcontrib>van Ree, Ronald</creatorcontrib><creatorcontrib>Mills, Clare</creatorcontrib><creatorcontrib>Grabenhenrich, Linus</creatorcontrib><creatorcontrib>Beyer, Kirsten</creatorcontrib><creatorcontrib>Keil, Thomas</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Allergy (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sigurdardottir, Sigurveig T.</au><au>Jonasson, Kristjan</au><au>Clausen, Michael</au><au>Lilja Bjornsdottir, Kristin</au><au>Sigurdardottir, Sigridur Erla</au><au>Roberts, Graham</au><au>Grimshaw, Kate</au><au>Papadopoulos, Nikolaos G.</au><au>Xepapadaki, Paraskevi</au><au>Fiandor, Ana</au><au>Quirce, Santiago</au><au>Sprikkelman, Aline B.</au><au>Hulshof, Lies</au><au>Kowalski, Marek L.</au><au>Kurowski, Marcin</au><au>Dubakiene, Ruta</au><au>Rudzeviciene, Odilija</au><au>Bellach, Johanna</au><au>Yürek, Songül</au><au>Reich, Andreas</au><au>Erhard, Sina Maria</au><au>Couch, Philip</au><au>Rivas, Montserrat Fernandez</au><au>van Ree, Ronald</au><au>Mills, Clare</au><au>Grabenhenrich, Linus</au><au>Beyer, Kirsten</au><au>Keil, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and early‐life risk factors of school‐age allergic multimorbidity: The EuroPrevall‐iFAAM birth cohort</atitle><jtitle>Allergy (Copenhagen)</jtitle><addtitle>Allergy</addtitle><date>2021-09</date><risdate>2021</risdate><volume>76</volume><issue>9</issue><spage>2855</spage><epage>2865</epage><pages>2855-2865</pages><issn>0105-4538</issn><eissn>1398-9995</eissn><abstract>Background
Coexistence of childhood asthma, eczema and allergic rhinitis is higher than can be expected by chance, suggesting a common mechanism. Data on allergic multimorbidity from a pan‐European, population‐based birth cohort study have been lacking. This study compares the prevalence and early‐life risk factors of these diseases in European primary school children.
Methods
In the prospective multicentre observational EuroPrevall‐iFAAM birth cohort study, we used standardized questionnaires on sociodemographics, medical history, parental allergies and lifestyle, and environmental exposures at birth, 12 and 24 months. At primary school age, parents answered ISAAC‐based questions on current asthma, rhinitis and eczema. Allergic multimorbidity was defined as the coexistence of at least two of these.
Results
From 10,563 children recruited at birth in 8 study centres, we included data from 5,572 children (mean age 8.2 years; 51.8% boys). Prevalence estimates were as follows: asthma, 8.1%; allergic rhinitis, 13.3%; and eczema, 12.0%. Allergic multimorbidity was seen in 7.0% of the whole cohort, ranging from 1.2% (Athens, Greece) to 10.9% (Madrid, Spain). Risk factors for allergic multimorbidity, identified with AICc, included family‐allergy‐score, odds ratio (OR) 1.50 (95% CI 1.32–1.70) per standard deviation; early‐life allergy symptoms, OR 2.72 (2.34–3.16) for each symptom; and caesarean birth, OR 1.35 (1.04–1.76). Female gender, OR 0.72 (0.58–0.90); older siblings, OR 0.79 (0.63–0.99); and day care, OR 0.81 (0.63–1.06) were protective factors.
Conclusion
Allergic multimorbidity should be regarded as an important chronic childhood disease in Europe. Some of the associated early‐life factors are modifiable and may be considered for prevention strategies.
Allergic multimorbidity (coexistence of asthma, eczema and allergic rhinitis) is common among European children at primary school age, with 7% of study participants affected. Protective factors identified in the study include female sex, having older siblings and attending day care. Risk factors include history of allergic diseases in first‐degree family members, early‐age symptoms and caesarean birth.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>33934363</pmid><doi>10.1111/all.14857</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9300-6625</orcidid><orcidid>https://orcid.org/0000-0002-8442-2774</orcidid><orcidid>https://orcid.org/0000-0002-4448-3468</orcidid><orcidid>https://orcid.org/0000-0003-2252-1248</orcidid><orcidid>https://orcid.org/0000-0002-6275-0910</orcidid><orcidid>https://orcid.org/0000-0002-9066-3128</orcidid><orcidid>https://orcid.org/0000-0001-9204-1923</orcidid><orcidid>https://orcid.org/0000-0002-9108-3360</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0105-4538 |
| ispartof | Allergy (Copenhagen), 2021-09, Vol.76 (9), p.2855-2865 |
| issn | 0105-4538 1398-9995 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8453757 |
| source | MEDLINE; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection) |
| subjects | Age allergic multimorbidity Allergic rhinitis Allergies Asthma Child Children Coexistence Cohort Studies Comorbidity Eczema Eczema - epidemiology Female Humans Hypersensitivity Infant, Newborn Male Multimorbidity Original ORIGINAL ARTICLES Population studies Pregnancy Prevalence Prospective Studies Rhinitis Rhinitis, Allergic - epidemiology Risk Factors Schools Surveys and Questionnaires |
| title | Prevalence and early‐life risk factors of school‐age allergic multimorbidity: The EuroPrevall‐iFAAM birth cohort |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T02%3A04%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevalence%20and%20early%E2%80%90life%20risk%20factors%20of%20school%E2%80%90age%20allergic%20multimorbidity:%20The%20EuroPrevall%E2%80%90iFAAM%20birth%20cohort&rft.jtitle=Allergy%20(Copenhagen)&rft.au=Sigurdardottir,%20Sigurveig%20T.&rft.date=2021-09&rft.volume=76&rft.issue=9&rft.spage=2855&rft.epage=2865&rft.pages=2855-2865&rft.issn=0105-4538&rft.eissn=1398-9995&rft_id=info:doi/10.1111/all.14857&rft_dat=%3Cproquest_pubme%3E2567800831%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2567800831&rft_id=info:pmid/33934363&rfr_iscdi=true |