Piperidine Azasugars Bearing Lipophilic Chains: Stereoselective Synthesis and Biological Activity as Inhibitors of Glucocerebrosidase (GCase)

We report a straightforward synthetic strategy for the preparation of trihydroxypiperidine azasugars decorated with lipophilic chains at both the nitrogen and the adjacent carbon as potential inhibitors of the lysosomal enzyme glucocerebrosidase (GCase), which is involved in Gaucher disease. The pro...

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Veröffentlicht in:	Journal of organic chemistry 2021-09, Vol.86 (18), p.12745-12761
Hauptverfasser:	Clemente, Francesca, Matassini, Camilla, Giachetti, Sara, Goti, Andrea, Morrone, Amelia, Martínez-Bailén, Macarena, Orta, Sara, Merino, Pedro, Cardona, Francesca
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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