Napabucasin Drug‐Drug Interaction Potential, Safety, Tolerability, and Pharmacokinetics Following Oral Dosing in Healthy Adult Volunteers

Napabucasin is an orally administered reactive oxygen species generator that is bioactivated by the intracellular antioxidant nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase 1. Napabucasin induces cell death in cancer cells, including cancer stem cells. This phase 1 study (NCT0341...

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Veröffentlicht in:	Clinical pharmacology in drug development 2021-08, Vol.10 (8), p.824-839
Hauptverfasser:	Dai, Xiaoshu, Karol, Michael D., Hitron, Matthew, Hard, Marjie L., Goulet, Matthew T., McLaughlin, Colleen F., Brantley, Scott J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism Benzofurans - administration & dosage Benzofurans - pharmacokinetics Breast cancer breast cancer resistance protein transporter Bupropion - administration & dosage Bupropion - pharmacokinetics Caffeine Caffeine - administration & dosage Caffeine - pharmacokinetics Cytochrome Cytochrome P-450 Enzyme System - metabolism cytochrome P450 Dextromethorphan - administration & dosage Dextromethorphan - pharmacokinetics Drug Interactions drug‐drug interactions Female Flurbiprofen - administration & dosage Flurbiprofen - pharmacokinetics Gene Expression Regulation - drug effects Half-Life Healthy Volunteers Humans Male Midazolam - administration & dosage Midazolam - pharmacokinetics napabucasin Naphthoquinones - administration & dosage Naphthoquinones - pharmacokinetics Neoplasm Proteins - metabolism Omeprazole - administration & dosage Omeprazole - pharmacokinetics Original Manuscript Pharmacokinetics phase 1 trial Reactive oxygen species Rosuvastatin Calcium - administration & dosage Rosuvastatin Calcium - pharmacokinetics Young Adult
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