Macular microvasculature differences in patients with macular hole after vitrectomy with internal limiting membrane removal or single-layered temporal inverted flap technique
Purpose To compare the macular microvasculature differences in cases with idiopathic macular hole (MH) after vitrectomy when using internal limiting membrane (ILM) removal or temporal inverted ILM flap technique (IFT). Method A total of 34 patients were included, of whom 20 were treated vitrectomy w...
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| Veröffentlicht in: | Eye (London) 2021-10, Vol.35 (10), p.2746-2753 |
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| creator | Karalezli, Aylin Kaderli, Sema Tamer Sul, Sabahattin |
| description | Purpose
To compare the macular microvasculature differences in cases with idiopathic macular hole (MH) after vitrectomy when using internal limiting membrane (ILM) removal or temporal inverted ILM flap technique (IFT).
Method
A total of 34 patients were included, of whom 20 were treated vitrectomy with ILM removal (group 1), and 14 were treated with IFT (group 2). The OCTA (RTVue; Optovue, Fremont, CA) parameters, including foveal avascular zone (FAZ), vessel density (VD) ratios in superficial capillary plexus (SCP), and deep capillary plexus (DCP) were evaluated at baseline and 6 months follow-up. The VD measurements in DCP and inner retinal thickness (IRT) in temporal and nasal sectors were compared in subanalyses.
Results
There was no significant difference in means of post-operative BCVA and FAZ between the two groups (
p
= 0.943,
p
= 0.760). The mean VDs of the DCP was significantly decreased at 6 months postoperatively in both groups (
p
|
| doi_str_mv | 10.1038/s41433-020-01301-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8452644</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2574548872</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-b91451ae8917415eeb2ea809f38a7949ad0bbf52864ae71412c2dd0963ec18993</originalsourceid><addsrcrecordid>eNp9ksmO1DAQhiMEYpqBF-CALHHhEvCWxL4goRGbNIgLSNwsJ6l0e2Q7je006pfiGakmzbAcOEWp_6vN9VfVY0afMyrUiyyZFKKmnNaUCcpqcafaMNm1dSMbebfaUN3QmnP-5aJ6kPMNpSh29H51IQQXjZBiU33_YIfF20SCG9J8sPn0V5YEZHTTBAniAJm4SPa2OIglk2-u7Eg4Z-1mD8ROBRI5uJJgKHM4roiLGI3WE--CKy5uSYDQJxuBJAjYypM5kYyCh9rbI_YaSYGwnxNKLh4gFYxM3u4xPOyi-7rAw-reZH2GR-fvZfX5zetPV-_q649v31-9uq4H2clS95rJhllQmnWSNQA9B6uonoSynZbajrTvp4arVlromGR84ONIdStgYEprcVm9XOvulz7AOODmOJXZJxdsOprZOvO3Et3ObOeDUbLhrZRY4Nm5QJpx7lxMcHkA73H_ecmGy1YyzRXtEH36D3ozL6eXQ6rp8JJKdRwpvlJ4ppwTTLfDMGpOdjCrHQzawfy0gxGY9OTPNW5Tft0fAbECGaW4hfS793_K_gAy5MZO</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2574548872</pqid></control><display><type>article</type><title>Macular microvasculature differences in patients with macular hole after vitrectomy with internal limiting membrane removal or single-layered temporal inverted flap technique</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>PubMed Central</source><creator>Karalezli, Aylin ; Kaderli, Sema Tamer ; Sul, Sabahattin</creator><creatorcontrib>Karalezli, Aylin ; Kaderli, Sema Tamer ; Sul, Sabahattin</creatorcontrib><description>Purpose
To compare the macular microvasculature differences in cases with idiopathic macular hole (MH) after vitrectomy when using internal limiting membrane (ILM) removal or temporal inverted ILM flap technique (IFT).
Method
A total of 34 patients were included, of whom 20 were treated vitrectomy with ILM removal (group 1), and 14 were treated with IFT (group 2). The OCTA (RTVue; Optovue, Fremont, CA) parameters, including foveal avascular zone (FAZ), vessel density (VD) ratios in superficial capillary plexus (SCP), and deep capillary plexus (DCP) were evaluated at baseline and 6 months follow-up. The VD measurements in DCP and inner retinal thickness (IRT) in temporal and nasal sectors were compared in subanalyses.
Results
There was no significant difference in means of post-operative BCVA and FAZ between the two groups (
p
= 0.943,
p
= 0.760). The mean VDs of the DCP was significantly decreased at 6 months postoperatively in both groups (
p
< 0.001,
p
< 0.001). The mean post-operative temporal VDs of DCP were similar in the two groups, but the mean post-operative nasal VDs of the DCP was lower in group 1 than in group 2 (
p
= 0.005 and
p
= 0.03 for parafovea and perifovea, respectively). The mean temporal IRTs were similar in the two groups, but paranasal and perinasal IRTs were significantly thinner in group 1 than in group 2 (
p
< 0.001,
p
< 0.001). The mean post-operative VDs of parafoveal and perifoveal temporal and nasal quadrants in DCP significantly and positively correlated with the IRTs.
Conclusion
Single-layered temporal IFT causes fewer VD changes when compared to complete ILM removal, especially in the DCP.</description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/s41433-020-01301-3</identifier><identifier>PMID: 33235343</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>14 ; 14/5 ; 692/308/409 ; 692/699/3161/3175 ; Diabetic retinopathy ; Humans ; Laboratory Medicine ; Medicine ; Medicine & Public Health ; Microvasculature ; Microvessels ; Ophthalmology ; Pharmaceutical Sciences/Technology ; Retinal Perforations - surgery ; Retinal Vessels ; Retrospective Studies ; Software ; Surgery ; Surgical Oncology ; Tomography, Optical Coherence ; Values ; Variance analysis ; Visual Acuity ; Vitrectomy</subject><ispartof>Eye (London), 2021-10, Vol.35 (10), p.2746-2753</ispartof><rights>The Author(s), under exclusive licence to The Royal College of Ophthalmologists 2020</rights><rights>2020. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.</rights><rights>The Author(s), under exclusive licence to The Royal College of Ophthalmologists 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-b91451ae8917415eeb2ea809f38a7949ad0bbf52864ae71412c2dd0963ec18993</citedby><cites>FETCH-LOGICAL-c474t-b91451ae8917415eeb2ea809f38a7949ad0bbf52864ae71412c2dd0963ec18993</cites><orcidid>0000-0003-4851-6527</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452644/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452644/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,41467,42536,51297,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33235343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karalezli, Aylin</creatorcontrib><creatorcontrib>Kaderli, Sema Tamer</creatorcontrib><creatorcontrib>Sul, Sabahattin</creatorcontrib><title>Macular microvasculature differences in patients with macular hole after vitrectomy with internal limiting membrane removal or single-layered temporal inverted flap technique</title><title>Eye (London)</title><addtitle>Eye</addtitle><addtitle>Eye (Lond)</addtitle><description>Purpose
To compare the macular microvasculature differences in cases with idiopathic macular hole (MH) after vitrectomy when using internal limiting membrane (ILM) removal or temporal inverted ILM flap technique (IFT).
Method
A total of 34 patients were included, of whom 20 were treated vitrectomy with ILM removal (group 1), and 14 were treated with IFT (group 2). The OCTA (RTVue; Optovue, Fremont, CA) parameters, including foveal avascular zone (FAZ), vessel density (VD) ratios in superficial capillary plexus (SCP), and deep capillary plexus (DCP) were evaluated at baseline and 6 months follow-up. The VD measurements in DCP and inner retinal thickness (IRT) in temporal and nasal sectors were compared in subanalyses.
Results
There was no significant difference in means of post-operative BCVA and FAZ between the two groups (
p
= 0.943,
p
= 0.760). The mean VDs of the DCP was significantly decreased at 6 months postoperatively in both groups (
p
< 0.001,
p
< 0.001). The mean post-operative temporal VDs of DCP were similar in the two groups, but the mean post-operative nasal VDs of the DCP was lower in group 1 than in group 2 (
p
= 0.005 and
p
= 0.03 for parafovea and perifovea, respectively). The mean temporal IRTs were similar in the two groups, but paranasal and perinasal IRTs were significantly thinner in group 1 than in group 2 (
p
< 0.001,
p
< 0.001). The mean post-operative VDs of parafoveal and perifoveal temporal and nasal quadrants in DCP significantly and positively correlated with the IRTs.
Conclusion
Single-layered temporal IFT causes fewer VD changes when compared to complete ILM removal, especially in the DCP.</description><subject>14</subject><subject>14/5</subject><subject>692/308/409</subject><subject>692/699/3161/3175</subject><subject>Diabetic retinopathy</subject><subject>Humans</subject><subject>Laboratory Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microvasculature</subject><subject>Microvessels</subject><subject>Ophthalmology</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Retinal Perforations - surgery</subject><subject>Retinal Vessels</subject><subject>Retrospective Studies</subject><subject>Software</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Tomography, Optical Coherence</subject><subject>Values</subject><subject>Variance analysis</subject><subject>Visual Acuity</subject><subject>Vitrectomy</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9ksmO1DAQhiMEYpqBF-CALHHhEvCWxL4goRGbNIgLSNwsJ6l0e2Q7je006pfiGakmzbAcOEWp_6vN9VfVY0afMyrUiyyZFKKmnNaUCcpqcafaMNm1dSMbebfaUN3QmnP-5aJ6kPMNpSh29H51IQQXjZBiU33_YIfF20SCG9J8sPn0V5YEZHTTBAniAJm4SPa2OIglk2-u7Eg4Z-1mD8ROBRI5uJJgKHM4roiLGI3WE--CKy5uSYDQJxuBJAjYypM5kYyCh9rbI_YaSYGwnxNKLh4gFYxM3u4xPOyi-7rAw-reZH2GR-fvZfX5zetPV-_q649v31-9uq4H2clS95rJhllQmnWSNQA9B6uonoSynZbajrTvp4arVlromGR84ONIdStgYEprcVm9XOvulz7AOODmOJXZJxdsOprZOvO3Et3ObOeDUbLhrZRY4Nm5QJpx7lxMcHkA73H_ecmGy1YyzRXtEH36D3ozL6eXQ6rp8JJKdRwpvlJ4ppwTTLfDMGpOdjCrHQzawfy0gxGY9OTPNW5Tft0fAbECGaW4hfS793_K_gAy5MZO</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Karalezli, Aylin</creator><creator>Kaderli, Sema Tamer</creator><creator>Sul, Sabahattin</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4851-6527</orcidid></search><sort><creationdate>20211001</creationdate><title>Macular microvasculature differences in patients with macular hole after vitrectomy with internal limiting membrane removal or single-layered temporal inverted flap technique</title><author>Karalezli, Aylin ; Kaderli, Sema Tamer ; Sul, Sabahattin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-b91451ae8917415eeb2ea809f38a7949ad0bbf52864ae71412c2dd0963ec18993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>14</topic><topic>14/5</topic><topic>692/308/409</topic><topic>692/699/3161/3175</topic><topic>Diabetic retinopathy</topic><topic>Humans</topic><topic>Laboratory Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microvasculature</topic><topic>Microvessels</topic><topic>Ophthalmology</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Retinal Perforations - surgery</topic><topic>Retinal Vessels</topic><topic>Retrospective Studies</topic><topic>Software</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Tomography, Optical Coherence</topic><topic>Values</topic><topic>Variance analysis</topic><topic>Visual Acuity</topic><topic>Vitrectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karalezli, Aylin</creatorcontrib><creatorcontrib>Kaderli, Sema Tamer</creatorcontrib><creatorcontrib>Sul, Sabahattin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karalezli, Aylin</au><au>Kaderli, Sema Tamer</au><au>Sul, Sabahattin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Macular microvasculature differences in patients with macular hole after vitrectomy with internal limiting membrane removal or single-layered temporal inverted flap technique</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><addtitle>Eye (Lond)</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>35</volume><issue>10</issue><spage>2746</spage><epage>2753</epage><pages>2746-2753</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><abstract>Purpose
To compare the macular microvasculature differences in cases with idiopathic macular hole (MH) after vitrectomy when using internal limiting membrane (ILM) removal or temporal inverted ILM flap technique (IFT).
Method
A total of 34 patients were included, of whom 20 were treated vitrectomy with ILM removal (group 1), and 14 were treated with IFT (group 2). The OCTA (RTVue; Optovue, Fremont, CA) parameters, including foveal avascular zone (FAZ), vessel density (VD) ratios in superficial capillary plexus (SCP), and deep capillary plexus (DCP) were evaluated at baseline and 6 months follow-up. The VD measurements in DCP and inner retinal thickness (IRT) in temporal and nasal sectors were compared in subanalyses.
Results
There was no significant difference in means of post-operative BCVA and FAZ between the two groups (
p
= 0.943,
p
= 0.760). The mean VDs of the DCP was significantly decreased at 6 months postoperatively in both groups (
p
< 0.001,
p
< 0.001). The mean post-operative temporal VDs of DCP were similar in the two groups, but the mean post-operative nasal VDs of the DCP was lower in group 1 than in group 2 (
p
= 0.005 and
p
= 0.03 for parafovea and perifovea, respectively). The mean temporal IRTs were similar in the two groups, but paranasal and perinasal IRTs were significantly thinner in group 1 than in group 2 (
p
< 0.001,
p
< 0.001). The mean post-operative VDs of parafoveal and perifoveal temporal and nasal quadrants in DCP significantly and positively correlated with the IRTs.
Conclusion
Single-layered temporal IFT causes fewer VD changes when compared to complete ILM removal, especially in the DCP.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33235343</pmid><doi>10.1038/s41433-020-01301-3</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4851-6527</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-222X |
| ispartof | Eye (London), 2021-10, Vol.35 (10), p.2746-2753 |
| issn | 0950-222X 1476-5454 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8452644 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; PubMed Central |
| subjects | 14 14/5 692/308/409 692/699/3161/3175 Diabetic retinopathy Humans Laboratory Medicine Medicine Medicine & Public Health Microvasculature Microvessels Ophthalmology Pharmaceutical Sciences/Technology Retinal Perforations - surgery Retinal Vessels Retrospective Studies Software Surgery Surgical Oncology Tomography, Optical Coherence Values Variance analysis Visual Acuity Vitrectomy |
| title | Macular microvasculature differences in patients with macular hole after vitrectomy with internal limiting membrane removal or single-layered temporal inverted flap technique |
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