Quantitative and qualitative assessment of plasma cell dyscrasias in dual-layer spectral CT
Objectives Virtual non-calcium (VNCa) images could improve assessment of plasma cell dyscrasias by enhancing visibility of bone marrow. Thus, VNCa images from dual-layer spectral CT (DLCT) were evaluated at different calcium suppression (CaSupp) indices, correlating results with apparent diffusion c...
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| Veröffentlicht in: | European radiology 2021-10, Vol.31 (10), p.7664-7673 |
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| creator | Brandelik, S. C. Skornitzke, S. Mokry, T. Sauer, S. Stiller, W. Nattenmüller, J. Kauczor, H. U. Weber, T. F. Do, T. D. |
| description | Objectives
Virtual non-calcium (VNCa) images could improve assessment of plasma cell dyscrasias by enhancing visibility of bone marrow. Thus, VNCa images from dual-layer spectral CT (DLCT) were evaluated at different calcium suppression (CaSupp) indices, correlating results with apparent diffusion coefficient (ADC) values from MRI.
Methods
Thirty-two patients with initial clinical diagnosis of a plasma cell dyscrasia before any chemotherapeutic treatment, who had undergone whole-body low-dose DLCT and MRI within 2 months, were retrospectively enrolled. VNCa images with CaSupp indices ranging from 25 to 95 in steps of 10, conventional CT images, and ADC maps were quantitatively analyzed using region-of-interests in the vertebral bodies C7, T12, L1-L5, and the iliac bone. Independent two-sample
t
-test, Wilcoxon-signed-rank test, Pearson’s correlation, and ROC analysis were performed.
Results
Eighteen patients had a non-diffuse, 14 a diffuse infiltration in conventional MRI. A significant difference between diffuse and non-diffuse infiltration was shown for VNCa-CT with CaSupp indices from 55 to 95, for conventional CT, and for ADC (each
p
< 0.0001). Significant quantitative correlation between VNCa-CT and MRI could be found with strongest correlation at CaSupp index 65 for L3 (
r
= 0.68,
p
< 0.0001) and averaged L1-L5 (
r
= 0.66,
p
< 0.0001). The optimum CT number cut-off point for differentiation between diffuse and non-diffuse infiltration at CaSupp index 65 for averaged L1-L5 was −1.6 HU (sensitivity 78.6%, specificity 75.0%).
Conclusion
Measurements in VNCa-CT showed the highest correlation with ADC at CaSupp index 65. VNCa technique may prove useful for evaluation of bone marrow infiltration if MRI is not feasible.
Key Points
• VNCa-CT images can support the evaluation of bone marrow infiltration in plasma cell dyscrasias.
• VNCa measurements of vertebral bodies show significant correlation with ADC in MRI.
• Averaging L1-L5 at CaSupp index 65 allowed quantitative detection of infiltration comparable to MRI ADC. |
| doi_str_mv | 10.1007/s00330-021-07821-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8452563</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2574558172</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-a52de8761c1280a4617bf0b08f594a60c49ac91393fae9fecd5a8181f253697e3</originalsourceid><addsrcrecordid>eNp9kUlrHDEQhUWIiSdO_kAOQZBLLh2XtpZ0CYTBWcBgAs4pB1GjVjttehmrug3z76PJOJPl4IuEqK9evdJj7JWAdwLAnhOAUlCBFBVYtz-fsJXQSlYCnH7KVuCVq6z3-pQ9J7oFAC-0fcZOlbJOGStX7PvXBce5m3Hu7hPHseF3C_bHN1EiGtI486nl2x5pQB5T3_NmRzEjdUi8G3lTeqoedylz2qY4Z-z5-voFO2mxp_Ty4T5j3z5eXK8_V5dXn76sP1xWUVs9V2hkk5ytRRTSAepa2E0LG3Ct8RpriNpj9EJ51WLybYqNQSecaKVRtbdJnbH3B93tshlSE4vdYiBsczdg3oUJu_BvZex-hJvpPjhtpKlVEXj7IJCnuyXRHIaO9mvimKaFgjRghdn_dkHf_IfeTksey3qFstoYJ6wslDxQMU9EObVHMwLCPrtwyC6U7MKv7AKUptd_r3Fs-R1WAdQBoFIab1L-M_sR2Z__66Wh</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2574558172</pqid></control><display><type>article</type><title>Quantitative and qualitative assessment of plasma cell dyscrasias in dual-layer spectral CT</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Brandelik, S. C. ; Skornitzke, S. ; Mokry, T. ; Sauer, S. ; Stiller, W. ; Nattenmüller, J. ; Kauczor, H. U. ; Weber, T. F. ; Do, T. D.</creator><creatorcontrib>Brandelik, S. C. ; Skornitzke, S. ; Mokry, T. ; Sauer, S. ; Stiller, W. ; Nattenmüller, J. ; Kauczor, H. U. ; Weber, T. F. ; Do, T. D.</creatorcontrib><description>Objectives
Virtual non-calcium (VNCa) images could improve assessment of plasma cell dyscrasias by enhancing visibility of bone marrow. Thus, VNCa images from dual-layer spectral CT (DLCT) were evaluated at different calcium suppression (CaSupp) indices, correlating results with apparent diffusion coefficient (ADC) values from MRI.
Methods
Thirty-two patients with initial clinical diagnosis of a plasma cell dyscrasia before any chemotherapeutic treatment, who had undergone whole-body low-dose DLCT and MRI within 2 months, were retrospectively enrolled. VNCa images with CaSupp indices ranging from 25 to 95 in steps of 10, conventional CT images, and ADC maps were quantitatively analyzed using region-of-interests in the vertebral bodies C7, T12, L1-L5, and the iliac bone. Independent two-sample
t
-test, Wilcoxon-signed-rank test, Pearson’s correlation, and ROC analysis were performed.
Results
Eighteen patients had a non-diffuse, 14 a diffuse infiltration in conventional MRI. A significant difference between diffuse and non-diffuse infiltration was shown for VNCa-CT with CaSupp indices from 55 to 95, for conventional CT, and for ADC (each
p
< 0.0001). Significant quantitative correlation between VNCa-CT and MRI could be found with strongest correlation at CaSupp index 65 for L3 (
r
= 0.68,
p
< 0.0001) and averaged L1-L5 (
r
= 0.66,
p
< 0.0001). The optimum CT number cut-off point for differentiation between diffuse and non-diffuse infiltration at CaSupp index 65 for averaged L1-L5 was −1.6 HU (sensitivity 78.6%, specificity 75.0%).
Conclusion
Measurements in VNCa-CT showed the highest correlation with ADC at CaSupp index 65. VNCa technique may prove useful for evaluation of bone marrow infiltration if MRI is not feasible.
Key Points
• VNCa-CT images can support the evaluation of bone marrow infiltration in plasma cell dyscrasias.
• VNCa measurements of vertebral bodies show significant correlation with ADC in MRI.
• Averaging L1-L5 at CaSupp index 65 allowed quantitative detection of infiltration comparable to MRI ADC.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-021-07821-0</identifier><identifier>PMID: 33783572</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Bone marrow ; Bone Marrow Diseases ; Calcium ; Computed tomography ; Diagnostic Radiology ; Diffusion coefficient ; Evaluation ; Humans ; Image enhancement ; Imaging ; Infiltration ; Internal Medicine ; Interventional Radiology ; Magnetic resonance imaging ; Medical imaging ; Medicine ; Medicine & Public Health ; Monoclonal gammopathy ; Musculoskeletal ; Neuroradiology ; Paraproteinemias - diagnostic imaging ; Patients ; Plasma ; Radiology ; Rank tests ; Retrospective Studies ; Sensitivity and Specificity ; Tomography, X-Ray Computed ; Ultrasound ; Vertebrae</subject><ispartof>European radiology, 2021-10, Vol.31 (10), p.7664-7673</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-a52de8761c1280a4617bf0b08f594a60c49ac91393fae9fecd5a8181f253697e3</citedby><cites>FETCH-LOGICAL-c474t-a52de8761c1280a4617bf0b08f594a60c49ac91393fae9fecd5a8181f253697e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-021-07821-0$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-021-07821-0$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33783572$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brandelik, S. C.</creatorcontrib><creatorcontrib>Skornitzke, S.</creatorcontrib><creatorcontrib>Mokry, T.</creatorcontrib><creatorcontrib>Sauer, S.</creatorcontrib><creatorcontrib>Stiller, W.</creatorcontrib><creatorcontrib>Nattenmüller, J.</creatorcontrib><creatorcontrib>Kauczor, H. U.</creatorcontrib><creatorcontrib>Weber, T. F.</creatorcontrib><creatorcontrib>Do, T. D.</creatorcontrib><title>Quantitative and qualitative assessment of plasma cell dyscrasias in dual-layer spectral CT</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objectives
Virtual non-calcium (VNCa) images could improve assessment of plasma cell dyscrasias by enhancing visibility of bone marrow. Thus, VNCa images from dual-layer spectral CT (DLCT) were evaluated at different calcium suppression (CaSupp) indices, correlating results with apparent diffusion coefficient (ADC) values from MRI.
Methods
Thirty-two patients with initial clinical diagnosis of a plasma cell dyscrasia before any chemotherapeutic treatment, who had undergone whole-body low-dose DLCT and MRI within 2 months, were retrospectively enrolled. VNCa images with CaSupp indices ranging from 25 to 95 in steps of 10, conventional CT images, and ADC maps were quantitatively analyzed using region-of-interests in the vertebral bodies C7, T12, L1-L5, and the iliac bone. Independent two-sample
t
-test, Wilcoxon-signed-rank test, Pearson’s correlation, and ROC analysis were performed.
Results
Eighteen patients had a non-diffuse, 14 a diffuse infiltration in conventional MRI. A significant difference between diffuse and non-diffuse infiltration was shown for VNCa-CT with CaSupp indices from 55 to 95, for conventional CT, and for ADC (each
p
< 0.0001). Significant quantitative correlation between VNCa-CT and MRI could be found with strongest correlation at CaSupp index 65 for L3 (
r
= 0.68,
p
< 0.0001) and averaged L1-L5 (
r
= 0.66,
p
< 0.0001). The optimum CT number cut-off point for differentiation between diffuse and non-diffuse infiltration at CaSupp index 65 for averaged L1-L5 was −1.6 HU (sensitivity 78.6%, specificity 75.0%).
Conclusion
Measurements in VNCa-CT showed the highest correlation with ADC at CaSupp index 65. VNCa technique may prove useful for evaluation of bone marrow infiltration if MRI is not feasible.
Key Points
• VNCa-CT images can support the evaluation of bone marrow infiltration in plasma cell dyscrasias.
• VNCa measurements of vertebral bodies show significant correlation with ADC in MRI.
• Averaging L1-L5 at CaSupp index 65 allowed quantitative detection of infiltration comparable to MRI ADC.</description><subject>Bone marrow</subject><subject>Bone Marrow Diseases</subject><subject>Calcium</subject><subject>Computed tomography</subject><subject>Diagnostic Radiology</subject><subject>Diffusion coefficient</subject><subject>Evaluation</subject><subject>Humans</subject><subject>Image enhancement</subject><subject>Imaging</subject><subject>Infiltration</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Magnetic resonance imaging</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Monoclonal gammopathy</subject><subject>Musculoskeletal</subject><subject>Neuroradiology</subject><subject>Paraproteinemias - diagnostic imaging</subject><subject>Patients</subject><subject>Plasma</subject><subject>Radiology</subject><subject>Rank tests</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Tomography, X-Ray Computed</subject><subject>Ultrasound</subject><subject>Vertebrae</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUlrHDEQhUWIiSdO_kAOQZBLLh2XtpZ0CYTBWcBgAs4pB1GjVjttehmrug3z76PJOJPl4IuEqK9evdJj7JWAdwLAnhOAUlCBFBVYtz-fsJXQSlYCnH7KVuCVq6z3-pQ9J7oFAC-0fcZOlbJOGStX7PvXBce5m3Hu7hPHseF3C_bHN1EiGtI486nl2x5pQB5T3_NmRzEjdUi8G3lTeqoedylz2qY4Z-z5-voFO2mxp_Ty4T5j3z5eXK8_V5dXn76sP1xWUVs9V2hkk5ytRRTSAepa2E0LG3Ct8RpriNpj9EJ51WLybYqNQSecaKVRtbdJnbH3B93tshlSE4vdYiBsczdg3oUJu_BvZex-hJvpPjhtpKlVEXj7IJCnuyXRHIaO9mvimKaFgjRghdn_dkHf_IfeTksey3qFstoYJ6wslDxQMU9EObVHMwLCPrtwyC6U7MKv7AKUptd_r3Fs-R1WAdQBoFIab1L-M_sR2Z__66Wh</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Brandelik, S. C.</creator><creator>Skornitzke, S.</creator><creator>Mokry, T.</creator><creator>Sauer, S.</creator><creator>Stiller, W.</creator><creator>Nattenmüller, J.</creator><creator>Kauczor, H. U.</creator><creator>Weber, T. F.</creator><creator>Do, T. D.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211001</creationdate><title>Quantitative and qualitative assessment of plasma cell dyscrasias in dual-layer spectral CT</title><author>Brandelik, S. C. ; Skornitzke, S. ; Mokry, T. ; Sauer, S. ; Stiller, W. ; Nattenmüller, J. ; Kauczor, H. U. ; Weber, T. F. ; Do, T. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-a52de8761c1280a4617bf0b08f594a60c49ac91393fae9fecd5a8181f253697e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bone marrow</topic><topic>Bone Marrow Diseases</topic><topic>Calcium</topic><topic>Computed tomography</topic><topic>Diagnostic Radiology</topic><topic>Diffusion coefficient</topic><topic>Evaluation</topic><topic>Humans</topic><topic>Image enhancement</topic><topic>Imaging</topic><topic>Infiltration</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Magnetic resonance imaging</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Monoclonal gammopathy</topic><topic>Musculoskeletal</topic><topic>Neuroradiology</topic><topic>Paraproteinemias - diagnostic imaging</topic><topic>Patients</topic><topic>Plasma</topic><topic>Radiology</topic><topic>Rank tests</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Tomography, X-Ray Computed</topic><topic>Ultrasound</topic><topic>Vertebrae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brandelik, S. C.</creatorcontrib><creatorcontrib>Skornitzke, S.</creatorcontrib><creatorcontrib>Mokry, T.</creatorcontrib><creatorcontrib>Sauer, S.</creatorcontrib><creatorcontrib>Stiller, W.</creatorcontrib><creatorcontrib>Nattenmüller, J.</creatorcontrib><creatorcontrib>Kauczor, H. U.</creatorcontrib><creatorcontrib>Weber, T. F.</creatorcontrib><creatorcontrib>Do, T. D.</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brandelik, S. C.</au><au>Skornitzke, S.</au><au>Mokry, T.</au><au>Sauer, S.</au><au>Stiller, W.</au><au>Nattenmüller, J.</au><au>Kauczor, H. U.</au><au>Weber, T. F.</au><au>Do, T. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative and qualitative assessment of plasma cell dyscrasias in dual-layer spectral CT</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>31</volume><issue>10</issue><spage>7664</spage><epage>7673</epage><pages>7664-7673</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objectives
Virtual non-calcium (VNCa) images could improve assessment of plasma cell dyscrasias by enhancing visibility of bone marrow. Thus, VNCa images from dual-layer spectral CT (DLCT) were evaluated at different calcium suppression (CaSupp) indices, correlating results with apparent diffusion coefficient (ADC) values from MRI.
Methods
Thirty-two patients with initial clinical diagnosis of a plasma cell dyscrasia before any chemotherapeutic treatment, who had undergone whole-body low-dose DLCT and MRI within 2 months, were retrospectively enrolled. VNCa images with CaSupp indices ranging from 25 to 95 in steps of 10, conventional CT images, and ADC maps were quantitatively analyzed using region-of-interests in the vertebral bodies C7, T12, L1-L5, and the iliac bone. Independent two-sample
t
-test, Wilcoxon-signed-rank test, Pearson’s correlation, and ROC analysis were performed.
Results
Eighteen patients had a non-diffuse, 14 a diffuse infiltration in conventional MRI. A significant difference between diffuse and non-diffuse infiltration was shown for VNCa-CT with CaSupp indices from 55 to 95, for conventional CT, and for ADC (each
p
< 0.0001). Significant quantitative correlation between VNCa-CT and MRI could be found with strongest correlation at CaSupp index 65 for L3 (
r
= 0.68,
p
< 0.0001) and averaged L1-L5 (
r
= 0.66,
p
< 0.0001). The optimum CT number cut-off point for differentiation between diffuse and non-diffuse infiltration at CaSupp index 65 for averaged L1-L5 was −1.6 HU (sensitivity 78.6%, specificity 75.0%).
Conclusion
Measurements in VNCa-CT showed the highest correlation with ADC at CaSupp index 65. VNCa technique may prove useful for evaluation of bone marrow infiltration if MRI is not feasible.
Key Points
• VNCa-CT images can support the evaluation of bone marrow infiltration in plasma cell dyscrasias.
• VNCa measurements of vertebral bodies show significant correlation with ADC in MRI.
• Averaging L1-L5 at CaSupp index 65 allowed quantitative detection of infiltration comparable to MRI ADC.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33783572</pmid><doi>10.1007/s00330-021-07821-0</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Bone marrow Bone Marrow Diseases Calcium Computed tomography Diagnostic Radiology Diffusion coefficient Evaluation Humans Image enhancement Imaging Infiltration Internal Medicine Interventional Radiology Magnetic resonance imaging Medical imaging Medicine Medicine & Public Health Monoclonal gammopathy Musculoskeletal Neuroradiology Paraproteinemias - diagnostic imaging Patients Plasma Radiology Rank tests Retrospective Studies Sensitivity and Specificity Tomography, X-Ray Computed Ultrasound Vertebrae |
| title | Quantitative and qualitative assessment of plasma cell dyscrasias in dual-layer spectral CT |
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