APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation

The ε4 allele of APOE-encoding apolipoprotein (ApoE) is one of the strongest genetic risk factors for Alzheimer’s disease (AD). One of the overarching questions is whether and how this astrocyte-enriched risk factor initiates AD-associated pathology in neurons such as amyloid-β (Aβ) accumulation. He...

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Veröffentlicht in:	Stem cell reports 2021-09, Vol.16 (9), p.2128-2137
Hauptverfasser:	Lee, Se-In, Jeong, Woojin, Lim, Heejin, Cho, Sukhee, Lee, Hyein, Jang, Yonghee, Cho, Joonho, Bae, Simsung, Lin, Yuan-Ta, Tsai, Li-Huei, Moon, Dae Won, Seo, Jinsoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - etiology Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - biosynthesis Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism apolipoprotein E Apolipoprotein E4 - genetics Apolipoprotein E4 - metabolism Astrocytes - metabolism Biomarkers Cell Communication cholesterol Cholesterol - metabolism Culture Media, Conditioned - metabolism Culture Media, Conditioned - pharmacology Extracellular Space - metabolism human induced pluripotent stem cells Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - drug effects Induced Pluripotent Stem Cells - metabolism lipid rafts Membrane Microdomains - metabolism Neurons - drug effects Neurons - metabolism
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