The role of AMP‐activated protein kinase α1‐mediated endoplasmic reticulum stress in alleviating the toxic effect of uremic toxin indoxyl sulfate on vascular endothelial cells by Klotho

Recently, the Klotho protein (Klotho) has received substantial attention as protective factor against cardiovascular complications of chronic kidney disease (CKD). However, the direct effect and mechanism of Klotho on endothelial cells injury are not well‐known. In this study, we incubated human vei...

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Veröffentlicht in:	Journal of applied toxicology 2021-09, Vol.41 (9), p.1446-1455
Hauptverfasser:	Chen, Cheng, Wu, Lin, Xie, Caidie, Zhao, Xiufen, Mao, Huijuan, Xing, Changying
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion AMP AMP-Activated Protein Kinases - antagonists & inhibitors AMP-Activated Protein Kinases - drug effects AMP‐activated protein kinase α1 Apoptosis Apoptosis - drug effects Cell adhesion Cell adhesion molecules Cell Survival - drug effects Cell viability Complications Endoplasmic reticulum Endoplasmic Reticulum Chaperone BiP - metabolism endoplasmic reticulum stress Endoplasmic Reticulum Stress - drug effects Endothelial cells Enzyme Inhibitors - pharmacology Human Umbilical Vein Endothelial Cells - drug effects Humans Indican - toxicity indoxyl sulfate Injuries Intercellular Adhesion Molecule-1 - drug effects Kidney diseases Kinases Klotho protein Klotho Proteins - metabolism Phosphorylation Protein kinase Proteins Renal Insufficiency, Chronic - metabolism RNA, Small Interfering - pharmacology Stress Sulfates Toxins Transcription Factor CHOP - metabolism uremic toxin Uremic Toxins - toxicity Vascular Cell Adhesion Molecule-1 - drug effects
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