Absolute quantification of tumor antigens using embedded MHC-I isotopologue calibrants

Absolute quantification measurements (copies per cell) of peptide major histocompatibility complex (pMHC) antigens are necessary to inform targeted immunotherapy drug design; however, existing methods for absolute quantification have critical limitations. Here, we present a platform termed SureQuant...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-09, Vol.118 (37), p.1-3
Hauptverfasser:	Stopfer, Lauren E., Gajadhar, Aaron S., Patel, Bhavin, Gallien, Sebastien, Frederick, Dennie T., Boland, Genevieve M., Sullivan, Ryan J., White, Forest M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen (tumor-associated) Antigen Presentation - drug effects Antigen Presentation - immunology Antigens Antigens, Neoplasm - analysis Antigens, Neoplasm - drug effects Antigens, Neoplasm - immunology Benzimidazoles - pharmacology Biological Sciences BRIEF REPORTS Drug development Histocompatibility Antigens Class I - immunology Histocompatibility Antigens Class I - metabolism Humans Immunotherapy Major histocompatibility complex MAP Kinase Kinase 1 - antagonists & inhibitors Mass spectrometry Mass spectroscopy MEK inhibitors Melanoma Melanoma - drug therapy Melanoma - immunology Melanoma - metabolism Tumor Cells, Cultured Tumors
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