IL-6 enhances CD4 cell motility by sustaining mitochondrial Ca2+ through the noncanonical STAT3 pathway
Interleukin 6 (IL-6) is known to regulate the CD4 T cell function by inducing gene expression of a number of cytokines through activation of Stat3 transcription factor. Here, we reveal that IL-6 strengthens the mechanics of CD4 T cells. The presence of IL-6 during activation of mouse and human CD4 T...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2021-09, Vol.118 (37), p.1-10 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Valença-Pereira, Felipe Fang, Qian Marié, Isabelle J. Giddings, Emily L. Fortner, Karen A. Yang, Rui Villarino, Alejandro V. Huang, Yina H. Frank, David A. Wen, Haitao Levy, David E. Rincon, Mercedes |
| description | Interleukin 6 (IL-6) is known to regulate the CD4 T cell function by inducing gene expression of a number of cytokines through activation of Stat3 transcription factor. Here, we reveal that IL-6 strengthens the mechanics of CD4 T cells. The presence of IL-6 during activation of mouse and human CD4 T cells enhances their motility (random walk and exploratory spread), resulting in an increase in travel distance and higher velocity. This is an intrinsic effect of IL-6 on CD4 T-cell fitness that involves an increase in mitochondrial Ca2+. Although Stat3 transcriptional activity is dispensable for this process, IL-6 uses mitochondrial Stat3 to enhance mitochondrial Ca2+-mediated motility of CD4 T cells. Thus, through a noncanonical pathway, IL-6 can improve competitive fitness of CD4 T cells by facilitating cell motility. These results could lead to alternative therapeutic strategies for inflammatory diseases in which IL-6 plays a pathogenic role. |
| doi_str_mv | 10.1073/pnas.2103444118 |
| format | Article |
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These results could lead to alternative therapeutic strategies for inflammatory diseases in which IL-6 plays a pathogenic role.</description><subject>Biological Sciences</subject><subject>Calcium (mitochondrial)</subject><subject>Calcium ions</subject><subject>CD4 antigen</subject><subject>Cytokines</subject><subject>Fitness</subject><subject>Gene expression</subject><subject>Inflammatory diseases</subject><subject>Interleukin 6</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Mitochondria</subject><subject>Motility</subject><subject>Random walk</subject><subject>Stat3 protein</subject><subject>Transcription activation</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdkE1r3DAQhkVJaDZpzz0VBLkUghONPizrEgjbpAks9JDt2cxa8lqLLW0sOWH_fR0SCull3sP78DAzhHwDdglMi6t9wHTJgQkpJUD1iSyAGShKadgRWTDGdVFJLk_IaUo7xphRFftMToRUTBsjFmT7sCpK6kKHoXGJLn9K2ri-p0PMvvf5QDcHmqaU0QcftnTwOTZdDHb02NMl8guauzFO225OR0MMDc7DN3P7uL5ZC7rH3L3g4Qs5brFP7ut7npE_d7fr5X2x-v3rYXmzKnZCyFxUHLXYtNYa0QA4JQ2gArTKSWxLw0vUleVtyxloBAHW8EahNI6rUnJrxRm5fvPup83gbONCHrGv96MfcDzUEX39sQm-q7fxua6kNJKJWfDjXTDGp8mlXA8-vb4Eg4tTqrnSYKDkhs_o-X_oLk5jmM97pURVGQVmpr6_UbuU4_hvE66ZVrpk4i9zz4j-</recordid><startdate>20210914</startdate><enddate>20210914</enddate><creator>Valença-Pereira, Felipe</creator><creator>Fang, Qian</creator><creator>Marié, Isabelle J.</creator><creator>Giddings, Emily L.</creator><creator>Fortner, Karen A.</creator><creator>Yang, Rui</creator><creator>Villarino, Alejandro V.</creator><creator>Huang, Yina H.</creator><creator>Frank, David A.</creator><creator>Wen, Haitao</creator><creator>Levy, David E.</creator><creator>Rincon, Mercedes</creator><general>National Academy of Sciences</general><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210914</creationdate><title>IL-6 enhances CD4 cell motility by sustaining mitochondrial Ca2+ through the noncanonical STAT3 pathway</title><author>Valença-Pereira, Felipe ; 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| source | JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Biological Sciences Calcium (mitochondrial) Calcium ions CD4 antigen Cytokines Fitness Gene expression Inflammatory diseases Interleukin 6 Lymphocytes Lymphocytes T Mitochondria Motility Random walk Stat3 protein Transcription activation |
| title | IL-6 enhances CD4 cell motility by sustaining mitochondrial Ca2+ through the noncanonical STAT3 pathway |
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