Usefulness of Circulating Tumor DNA in Identifying Somatic Mutations and Tracking Tumor Evolution in Patients With Non-small Cell Lung Cancer

The usefulness of circulating tumor DNA (ctDNA) in detecting mutations and monitoring treatment response has not been well studied beyond a few actionable biomarkers in non-small cell lung cancer (NSCLC). How does the usefulness of ctDNA analysis compare with that of solid tumor biopsy analysis in p...

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Veröffentlicht in:	Chest 2021-09, Vol.160 (3), p.1095-1107
Hauptverfasser:	Roosan, Moom R., Mambetsariev, Isa, Pharaon, Rebecca, Fricke, Jeremy, Husain, Hatim, Reckamp, Karen L., Koczywas, Marianna, Massarelli, Erminia, Bild, Andrea H., Salgia, Ravi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers, Tumor - genetics Biopsy - methods Biopsy - statistics & numerical data Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology circulating tumor DNA Circulating Tumor DNA - genetics Class I Phosphatidylinositol 3-Kinases - genetics ErbB Receptors - genetics Female Humans Lung Neoplasms - genetics Lung Neoplasms - mortality Lung Neoplasms - pathology Male Molecular Targeted Therapy - methods Molecular Targeted Therapy - standards Mutation non-small cell lung cancer overall survival Precision Medicine - methods Precision Medicine - standards precision oncology Progression-Free Survival Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) - genetics Quality Improvement Thoracic Oncology: Original Research
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