Metabolic control of TFH cells and humoral immunity by phosphatidylethanolamine

T follicular helper (T FH ) cells are crucial for B cell-mediated humoral immunity 1 . Although transcription factors such as BCL6 drive the differentiation of T FH cells 2 , 3 , it is unclear whether and how post-transcriptional and metabolic programs enforce T FH cell programming. Here we show tha...

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Veröffentlicht in:	Nature (London) 2021-07, Vol.595 (7869), p.724-729
Hauptverfasser:	Fu, Guotong, Guy, Clifford S., Chapman, Nicole M., Palacios, Gustavo, Wei, Jun, Zhou, Peipei, Long, Lingyun, Wang, Yong-Dong, Qian, Chenxi, Dhungana, Yogesh, Huang, Hongling, KC, Anil, Shi, Hao, Rankin, Sherri, Brown, Scott A., Johnson, Amanda, Wakefield, Randall, Robinson, Camenzind G., Liu, Xueyan, Sheyn, Anthony, Yu, Jiyang, Jackowski, Suzanne, Chi, Hongbo
Format:	Artikel
Sprache:	eng
Schlagworte:	13 14/19 14/28 631/250/1619/554/1898/1270 631/250/2152/1566/2493 64/60 96/106 96/31 96/95 Bcl-6 protein Biosynthesis Cell differentiation Choline CXCR5 protein Differentiation (biology) Enzymes Ethanolamine Genes Humanities and Social Sciences Humoral immunity Immune response (humoral) Immunity Infections Internalization Kinases Lipid metabolism Lipids Localization Lymphocytes Lymphocytes B Lymphocytes T Metabolism multidisciplinary Phosphatidylethanolamine Phospholipids Post-transcription Science Science (multidisciplinary) Signal transduction Synthesis Transcription factors
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