Epetraborole Is Active against Mycobacterium abscessus

Epetraborole Is Active against Mycobacterium abscessus

Benzoxaboroles are a new class of leucyl-tRNA synthetase inhibitors. We recently reported that the antitubercular 4-halogenated benzoxaboroles are active against Mycobacterium abscessus. Here, we find that the nonhalogenated benzoxaborole epetraborole, a clinical candidate developed for Gram-negativ...

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Veröffentlicht in:Antimicrobial agents and chemotherapy 2021-09, Vol.65 (10), p.e0115621-e0115621
Hauptverfasser: Ganapathy, Uday S, Gengenbacher, Martin, Dick, Thomas
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Antimicrobial Chemotherapy
Experimental Therapeutics
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container_title Antimicrobial agents and chemotherapy
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creator Ganapathy, Uday S
Gengenbacher, Martin
Dick, Thomas
description Benzoxaboroles are a new class of leucyl-tRNA synthetase inhibitors. We recently reported that the antitubercular 4-halogenated benzoxaboroles are active against Mycobacterium abscessus. Here, we find that the nonhalogenated benzoxaborole epetraborole, a clinical candidate developed for Gram-negative infections, is also active against M. abscessus in vitro and in a mouse model of infection. This expands the repertoire of advanced lead compounds for the discovery of a benzoxaborole-based candidate to treat M. abscessus lung disease.
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Experimental Therapeutics
title Epetraborole Is Active against Mycobacterium abscessus
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