Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB-Mediated Production of CXCL1

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with few effective therapeutic options. PDAC is characterized by an extensive fibroinflammatory stroma that includes abundant infiltrating immune cells. Tumor-associated macrophages (TAM) are prevalent within the stroma and are key drive...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2021-08, Vol.81 (16), p.4305-4318
Hauptverfasser:	Kemp, Samantha B, Carpenter, Eileen S, Steele, Nina G, Donahue, Katelyn L, Nwosu, Zeribe C, Pacheco, Amanda, Velez-Delgado, Ashley, Menjivar, Rosa E, Lima, Fatima, The, Stephanie, Espinoza, Carlos E, Brown, Kristee, Long, Daniel, Lyssiotis, Costas A, Rao, Arvind, Zhang, Yaqing, Pasca di Magliano, Marina, Crawford, Howard C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins E - metabolism Cell Line, Tumor Chemokine CXCL1 - biosynthesis Fibroblasts - metabolism Humans Immune System Immunosuppression Therapy Inflammation Macrophages - metabolism Mass Spectrometry Mice Mice, Inbred C57BL Mice, Knockout, ApoE NF-kappa B - metabolism Pancreatic Neoplasms - immunology Pancreatic Neoplasms - metabolism Receptors, LDL - metabolism RNA-Seq Signal Transduction Single-Cell Analysis Treatment Outcome
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