Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID‐19

Background The long‐term sequalae of COVID‐19 remain poorly characterized. We assessed persistent symptoms in previously hospitalized patients with COVID‐19 and assessed potential risk factors. Methods Data were collected from patients discharged from 4 hospitals in Moscow, Russia between 8 April an...

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Veröffentlicht in:	Clinical and experimental allergy 2021-09, Vol.51 (9), p.1107-1120
Hauptverfasser:	Munblit, Daniel, Bobkova, Polina, Spiridonova, Ekaterina, Shikhaleva, Anastasia, Gamirova, Aysylu, Blyuss, Oleg, Nekliudov, Nikita, Bugaeva, Polina, Andreeva, Margarita, DunnGalvin, Audrey, Comberiati, Pasquale, Apfelbacher, Christian, Genuneit, Jon, Avdeev, Sergey, Kapustina, Valentina, Guekht, Alla, Fomin, Victor, Svistunov, Andrey A., Timashev, Peter, Subbot, Vladislav S., Royuk, Valery V., Drake, Thomas M., Hanson, Sarah Wulf, Merson, Laura, Carson, Gail, Horby, Peter, Sigfrid, Louise, Scott, Janet T., Semple, Malcolm G., Warner, John O., Vos, Theo, Olliaro, Piero, Glybochko, Petr, Butnaru, Denis, Abdeeva, Elina, Alekseeva, Nikol, Antsiferova, Elena, Artigas, Elena, Bairashevskaia, Anastasiia, Belkina, Anna, Bezrukov, Vadim, Bordyugov, Semyon, Bratukhina, Maria, Chen, Jessica, Deunezhewa, Salima, Elifkhanova, Khalisa, Ezhova, Anastasia, Filippova, Yulia, Frolova, Aleksandra, Ganieva, Julia, Gorina, Anastasia, Kalan, Yulia, Kirillov, Bogdan, Korgunova, Mariia, Krupina, Alexandra, Kuznetsova, Anna, Listovskaia, Ekaterina, Mikheeva, Margarita, Mursalova, Aigun, Ogandzhanova, Marina, Parr, Callum, Rumyantsev, Mikhail, Smirnov, Denis, Shishkina, Nataliya, El‐Taravi, Yasmin, Varaksina, Maria, Vodianova, Maria, Zezyulina, Anna
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Sprache:	eng
Schlagworte:	Adolescent Adult Aftercare Aged Aged, 80 and over Asthma COVID-19 COVID-19 - epidemiology COVID-19 Drug Treatment COVID-19 Testing Fatigue Female Follow-Up Studies Hospitalization Humans Incidence Long COVID Lung diseases Male Middle Aged ORIGINAL ARTICLES Original ‐asthma and Rhinitis PASC Patients postacute sequelae SARS‐CoV‐2 infection post‐COVID Condition post‐COVID Syndrome Risk Factors Russia - epidemiology SARS-CoV-2 Surveys and Questionnaires
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creator	Munblit, Daniel Bobkova, Polina Spiridonova, Ekaterina Shikhaleva, Anastasia Gamirova, Aysylu Blyuss, Oleg Nekliudov, Nikita Bugaeva, Polina Andreeva, Margarita DunnGalvin, Audrey Comberiati, Pasquale Apfelbacher, Christian Genuneit, Jon Avdeev, Sergey Kapustina, Valentina Guekht, Alla Fomin, Victor Svistunov, Andrey A. Timashev, Peter Subbot, Vladislav S. Royuk, Valery V. Drake, Thomas M. Hanson, Sarah Wulf Merson, Laura Carson, Gail Horby, Peter Sigfrid, Louise Scott, Janet T. Semple, Malcolm G. Warner, John O. Vos, Theo Olliaro, Piero Glybochko, Petr Butnaru, Denis Abdeeva, Elina Alekseeva, Nikol Antsiferova, Elena Artigas, Elena Bairashevskaia, Anastasiia Belkina, Anna Bezrukov, Vadim Bordyugov, Semyon Bratukhina, Maria Chen, Jessica Deunezhewa, Salima Elifkhanova, Khalisa Ezhova, Anastasia Filippova, Yulia Frolova, Aleksandra Ganieva, Julia Gorina, Anastasia Kalan, Yulia Kirillov, Bogdan Korgunova, Mariia Krupina, Alexandra Kuznetsova, Anna Listovskaia, Ekaterina Mikheeva, Margarita Mursalova, Aigun Ogandzhanova, Marina Parr, Callum Rumyantsev, Mikhail Smirnov, Denis Shishkina, Nataliya El‐Taravi, Yasmin Varaksina, Maria Vodianova, Maria Zezyulina, Anna
description	Background The long‐term sequalae of COVID‐19 remain poorly characterized. We assessed persistent symptoms in previously hospitalized patients with COVID‐19 and assessed potential risk factors. Methods Data were collected from patients discharged from 4 hospitals in Moscow, Russia between 8 April and 10 July 2020. Participants were interviewed via telephone using an ISARIC Long‐term Follow‐up Study questionnaire. Results 2,649 of 4755 (56%) discharged patients were successfully evaluated, at median 218 (IQR 200, 236) days post‐discharge. COVID‐19 diagnosis was clinical in 1291 and molecular in 1358. Most cases were mild, but 902 (34%) required supplemental oxygen and 68 (2.6%) needed ventilatory support. Median age was 56 years (IQR 46, 66) and 1,353 (51.1%) were women. Persistent symptoms were reported by 1247 (47.1%) participants, with fatigue (21.2%), shortness of breath (14.5%) and forgetfulness (9.1%) the most common symptoms and chronic fatigue (25%) and respiratory (17.2%) the most common symptom categories. Female sex was associated with any persistent symptom category OR 1.83 (95% CI 1.55 to 2.17) with association being strongest for dermatological (3.26, 2.36 to 4.57) symptoms. Asthma and chronic pulmonary disease were not associated with persistent symptoms overall, but asthma was associated with neurological (1.95, 1.25 to 2.98) and mood and behavioural changes (2.02, 1.24 to 3.18), and chronic pulmonary disease was associated with chronic fatigue (1.68, 1.21 to 2.32). Conclusions Almost half of adults admitted to hospital due to COVID‐19 reported persistent symptoms 6 to 8 months after discharge. Fatigue and respiratory symptoms were most common, and female sex was associated with persistent symptoms. Word cloud showing persistent symptoms 6–8 months since hospital discharge in people previously hospitalised with COVID‐19.
doi_str_mv	10.1111/cea.13997
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We assessed persistent symptoms in previously hospitalized patients with COVID‐19 and assessed potential risk factors. Methods Data were collected from patients discharged from 4 hospitals in Moscow, Russia between 8 April and 10 July 2020. Participants were interviewed via telephone using an ISARIC Long‐term Follow‐up Study questionnaire. Results 2,649 of 4755 (56%) discharged patients were successfully evaluated, at median 218 (IQR 200, 236) days post‐discharge. COVID‐19 diagnosis was clinical in 1291 and molecular in 1358. Most cases were mild, but 902 (34%) required supplemental oxygen and 68 (2.6%) needed ventilatory support. Median age was 56 years (IQR 46, 66) and 1,353 (51.1%) were women. Persistent symptoms were reported by 1247 (47.1%) participants, with fatigue (21.2%), shortness of breath (14.5%) and forgetfulness (9.1%) the most common symptoms and chronic fatigue (25%) and respiratory (17.2%) the most common symptom categories. Female sex was associated with any persistent symptom category OR 1.83 (95% CI 1.55 to 2.17) with association being strongest for dermatological (3.26, 2.36 to 4.57) symptoms. Asthma and chronic pulmonary disease were not associated with persistent symptoms overall, but asthma was associated with neurological (1.95, 1.25 to 2.98) and mood and behavioural changes (2.02, 1.24 to 3.18), and chronic pulmonary disease was associated with chronic fatigue (1.68, 1.21 to 2.32). Conclusions Almost half of adults admitted to hospital due to COVID‐19 reported persistent symptoms 6 to 8 months after discharge. Fatigue and respiratory symptoms were most common, and female sex was associated with persistent symptoms. Word cloud showing persistent symptoms 6–8 months since hospital discharge in people previously hospitalised with COVID‐19.</description><identifier>ISSN: 0954-7894</identifier><identifier>ISSN: 1365-2222</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1111/cea.13997</identifier><identifier>PMID: 34351016</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Adult ; Aftercare ; Aged ; Aged, 80 and over ; Asthma ; COVID-19 ; COVID-19 - epidemiology ; COVID-19 Drug Treatment ; COVID-19 Testing ; Fatigue ; Female ; Follow-Up Studies ; Hospitalization ; Humans ; Incidence ; Long COVID ; Lung diseases ; Male ; Middle Aged ; ORIGINAL ARTICLES ; Original ‐asthma and Rhinitis ; PASC ; Patients ; postacute sequelae SARS‐CoV‐2 infection ; post‐COVID Condition ; post‐COVID Syndrome ; Risk Factors ; Russia - epidemiology ; SARS-CoV-2 ; Surveys and Questionnaires</subject><ispartof>Clinical and experimental allergy, 2021-09, Vol.51 (9), p.1107-1120</ispartof><rights>2021 John Wiley & Sons Ltd</rights><rights>2021 John Wiley & Sons Ltd.</rights><rights>Copyright © 2021 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5377-c9ebff0b7a284ae3ddf6f694c8a3b5bb73d2375607ebb3af808bdf157fe249523</citedby><cites>FETCH-LOGICAL-c5377-c9ebff0b7a284ae3ddf6f694c8a3b5bb73d2375607ebb3af808bdf157fe249523</cites><orcidid>0000-0001-5764-1528 ; 0000-0001-9652-6856 ; 0000-0001-5209-9733 ; 0000-0002-7834-7819 ; 0000-0002-1540-3959 ; 0000-0001-9700-0418</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcea.13997$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcea.13997$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34351016$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Munblit, Daniel</creatorcontrib><creatorcontrib>Bobkova, Polina</creatorcontrib><creatorcontrib>Spiridonova, Ekaterina</creatorcontrib><creatorcontrib>Shikhaleva, Anastasia</creatorcontrib><creatorcontrib>Gamirova, Aysylu</creatorcontrib><creatorcontrib>Blyuss, Oleg</creatorcontrib><creatorcontrib>Nekliudov, Nikita</creatorcontrib><creatorcontrib>Bugaeva, Polina</creatorcontrib><creatorcontrib>Andreeva, Margarita</creatorcontrib><creatorcontrib>DunnGalvin, Audrey</creatorcontrib><creatorcontrib>Comberiati, Pasquale</creatorcontrib><creatorcontrib>Apfelbacher, Christian</creatorcontrib><creatorcontrib>Genuneit, Jon</creatorcontrib><creatorcontrib>Avdeev, Sergey</creatorcontrib><creatorcontrib>Kapustina, Valentina</creatorcontrib><creatorcontrib>Guekht, Alla</creatorcontrib><creatorcontrib>Fomin, Victor</creatorcontrib><creatorcontrib>Svistunov, Andrey A.</creatorcontrib><creatorcontrib>Timashev, Peter</creatorcontrib><creatorcontrib>Subbot, Vladislav S.</creatorcontrib><creatorcontrib>Royuk, Valery V.</creatorcontrib><creatorcontrib>Drake, Thomas M.</creatorcontrib><creatorcontrib>Hanson, Sarah Wulf</creatorcontrib><creatorcontrib>Merson, Laura</creatorcontrib><creatorcontrib>Carson, Gail</creatorcontrib><creatorcontrib>Horby, Peter</creatorcontrib><creatorcontrib>Sigfrid, Louise</creatorcontrib><creatorcontrib>Scott, Janet T.</creatorcontrib><creatorcontrib>Semple, Malcolm G.</creatorcontrib><creatorcontrib>Warner, John O.</creatorcontrib><creatorcontrib>Vos, Theo</creatorcontrib><creatorcontrib>Olliaro, Piero</creatorcontrib><creatorcontrib>Glybochko, Petr</creatorcontrib><creatorcontrib>Butnaru, Denis</creatorcontrib><creatorcontrib>Abdeeva, Elina</creatorcontrib><creatorcontrib>Alekseeva, Nikol</creatorcontrib><creatorcontrib>Antsiferova, Elena</creatorcontrib><creatorcontrib>Artigas, Elena</creatorcontrib><creatorcontrib>Bairashevskaia, Anastasiia</creatorcontrib><creatorcontrib>Belkina, Anna</creatorcontrib><creatorcontrib>Bezrukov, Vadim</creatorcontrib><creatorcontrib>Bordyugov, Semyon</creatorcontrib><creatorcontrib>Bratukhina, Maria</creatorcontrib><creatorcontrib>Chen, Jessica</creatorcontrib><creatorcontrib>Deunezhewa, Salima</creatorcontrib><creatorcontrib>Elifkhanova, Khalisa</creatorcontrib><creatorcontrib>Ezhova, Anastasia</creatorcontrib><creatorcontrib>Filippova, Yulia</creatorcontrib><creatorcontrib>Frolova, Aleksandra</creatorcontrib><creatorcontrib>Ganieva, Julia</creatorcontrib><creatorcontrib>Gorina, Anastasia</creatorcontrib><creatorcontrib>Kalan, Yulia</creatorcontrib><creatorcontrib>Kirillov, Bogdan</creatorcontrib><creatorcontrib>Korgunova, Mariia</creatorcontrib><creatorcontrib>Krupina, Alexandra</creatorcontrib><creatorcontrib>Kuznetsova, Anna</creatorcontrib><creatorcontrib>Listovskaia, Ekaterina</creatorcontrib><creatorcontrib>Mikheeva, Margarita</creatorcontrib><creatorcontrib>Mursalova, Aigun</creatorcontrib><creatorcontrib>Ogandzhanova, Marina</creatorcontrib><creatorcontrib>Parr, Callum</creatorcontrib><creatorcontrib>Rumyantsev, Mikhail</creatorcontrib><creatorcontrib>Smirnov, Denis</creatorcontrib><creatorcontrib>Shishkina, Nataliya</creatorcontrib><creatorcontrib>El‐Taravi, Yasmin</creatorcontrib><creatorcontrib>Varaksina, Maria</creatorcontrib><creatorcontrib>Vodianova, Maria</creatorcontrib><creatorcontrib>Zezyulina, Anna</creatorcontrib><creatorcontrib>Sechenov StopCOVID Research Team</creatorcontrib><title>Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID‐19</title><title>Clinical and experimental allergy</title><addtitle>Clin Exp Allergy</addtitle><description>Background The long‐term sequalae of COVID‐19 remain poorly characterized. We assessed persistent symptoms in previously hospitalized patients with COVID‐19 and assessed potential risk factors. Methods Data were collected from patients discharged from 4 hospitals in Moscow, Russia between 8 April and 10 July 2020. Participants were interviewed via telephone using an ISARIC Long‐term Follow‐up Study questionnaire. Results 2,649 of 4755 (56%) discharged patients were successfully evaluated, at median 218 (IQR 200, 236) days post‐discharge. COVID‐19 diagnosis was clinical in 1291 and molecular in 1358. Most cases were mild, but 902 (34%) required supplemental oxygen and 68 (2.6%) needed ventilatory support. Median age was 56 years (IQR 46, 66) and 1,353 (51.1%) were women. Persistent symptoms were reported by 1247 (47.1%) participants, with fatigue (21.2%), shortness of breath (14.5%) and forgetfulness (9.1%) the most common symptoms and chronic fatigue (25%) and respiratory (17.2%) the most common symptom categories. Female sex was associated with any persistent symptom category OR 1.83 (95% CI 1.55 to 2.17) with association being strongest for dermatological (3.26, 2.36 to 4.57) symptoms. Asthma and chronic pulmonary disease were not associated with persistent symptoms overall, but asthma was associated with neurological (1.95, 1.25 to 2.98) and mood and behavioural changes (2.02, 1.24 to 3.18), and chronic pulmonary disease was associated with chronic fatigue (1.68, 1.21 to 2.32). Conclusions Almost half of adults admitted to hospital due to COVID‐19 reported persistent symptoms 6 to 8 months after discharge. Fatigue and respiratory symptoms were most common, and female sex was associated with persistent symptoms. Word cloud showing persistent symptoms 6–8 months since hospital discharge in people previously hospitalised with COVID‐19.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aftercare</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Asthma</subject><subject>COVID-19</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 Drug Treatment</subject><subject>COVID-19 Testing</subject><subject>Fatigue</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Incidence</subject><subject>Long COVID</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Middle Aged</subject><subject>ORIGINAL ARTICLES</subject><subject>Original ‐asthma and Rhinitis</subject><subject>PASC</subject><subject>Patients</subject><subject>postacute sequelae SARS‐CoV‐2 infection</subject><subject>post‐COVID Condition</subject><subject>post‐COVID Syndrome</subject><subject>Risk Factors</subject><subject>Russia - epidemiology</subject><subject>SARS-CoV-2</subject><subject>Surveys and Questionnaires</subject><issn>0954-7894</issn><issn>1365-2222</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1qFTEYhoNY7LG68AYk4KYupk0mySTZCOVY7YFCN-o25NemzkzGZKZyXHkJXqNXYuxpSxX8IGSRJw_vxwvAC4yOcJ1j6_URJlLyR2CFSceats5jsEKS0YYLSffB01KuEEKESfEE7BNKGEa4WwG7GW10frQe6tHBHMsXGLSdUy4wpAwnn0sssx9nWLbDNKehwDhC7ZZ-LnDK_jqmpfRbeJnKFGfdx-_e3fxcX3zavP314yeWz8Be0H3xz2_vA_Dx3emH9VlzfvF-sz45bywjnDdWehMCMly3gmpPnAtd6CS1QhPDjOHEtYSzDnFvDNFBIGFcwIwH31LJWnIA3uy802IG72wNnXWvphwHnbcq6aj-fhnjpfqcrpWglHIqquDwVpDT18WXWQ2xWN_3evR1S9UyJmg9glT01T_oVVryWNerVCeIkIh0lXq9o2xOpWQf7sNgpP5Up2p16qa6yr58mP6evOuqAsc74Fvs_fb_JrU-PdkpfwPaaaXM</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Munblit, 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Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5764-1528</orcidid><orcidid>https://orcid.org/0000-0001-9652-6856</orcidid><orcidid>https://orcid.org/0000-0001-5209-9733</orcidid><orcidid>https://orcid.org/0000-0002-7834-7819</orcidid><orcidid>https://orcid.org/0000-0002-1540-3959</orcidid><orcidid>https://orcid.org/0000-0001-9700-0418</orcidid></search><sort><creationdate>202109</creationdate><title>Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID‐19</title><author>Munblit, Daniel ; Bobkova, Polina ; Spiridonova, Ekaterina ; Shikhaleva, Anastasia ; Gamirova, Aysylu ; Blyuss, Oleg ; Nekliudov, Nikita ; Bugaeva, Polina ; Andreeva, Margarita ; DunnGalvin, Audrey ; Comberiati, Pasquale ; Apfelbacher, Christian ; Genuneit, Jon ; Avdeev, Sergey ; Kapustina, Valentina ; Guekht, Alla ; Fomin, Victor ; Svistunov, Andrey A. ; Timashev, Peter ; Subbot, Vladislav S. ; Royuk, Valery V. ; Drake, Thomas M. ; Hanson, Sarah Wulf ; Merson, Laura ; Carson, Gail ; Horby, Peter ; Sigfrid, Louise ; Scott, Janet T. ; Semple, Malcolm G. ; Warner, John O. ; Vos, Theo ; Olliaro, Piero ; Glybochko, Petr ; Butnaru, Denis ; Abdeeva, Elina ; Alekseeva, Nikol ; Antsiferova, Elena ; Artigas, Elena ; Bairashevskaia, Anastasiia ; Belkina, Anna ; Bezrukov, Vadim ; Bordyugov, Semyon ; Bratukhina, Maria ; Chen, Jessica ; Deunezhewa, Salima ; Elifkhanova, Khalisa ; Ezhova, Anastasia ; Filippova, Yulia ; Frolova, Aleksandra ; Ganieva, Julia ; Gorina, Anastasia ; Kalan, Yulia ; Kirillov, Bogdan ; Korgunova, Mariia ; Krupina, Alexandra ; Kuznetsova, Anna ; Listovskaia, Ekaterina ; Mikheeva, Margarita ; Mursalova, Aigun ; Ogandzhanova, Marina ; Parr, Callum ; Rumyantsev, Mikhail ; Smirnov, Denis ; Shishkina, Nataliya ; El‐Taravi, Yasmin ; Varaksina, Maria ; Vodianova, Maria ; Zezyulina, Anna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5377-c9ebff0b7a284ae3ddf6f694c8a3b5bb73d2375607ebb3af808bdf157fe249523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aftercare</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Asthma</topic><topic>COVID-19</topic><topic>COVID-19 - epidemiology</topic><topic>COVID-19 Drug Treatment</topic><topic>COVID-19 Testing</topic><topic>Fatigue</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Incidence</topic><topic>Long COVID</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Middle Aged</topic><topic>ORIGINAL ARTICLES</topic><topic>Original ‐asthma and Rhinitis</topic><topic>PASC</topic><topic>Patients</topic><topic>postacute sequelae SARS‐CoV‐2 infection</topic><topic>post‐COVID Condition</topic><topic>post‐COVID Syndrome</topic><topic>Risk Factors</topic><topic>Russia - epidemiology</topic><topic>SARS-CoV-2</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Munblit, Daniel</creatorcontrib><creatorcontrib>Bobkova, Polina</creatorcontrib><creatorcontrib>Spiridonova, Ekaterina</creatorcontrib><creatorcontrib>Shikhaleva, Anastasia</creatorcontrib><creatorcontrib>Gamirova, Aysylu</creatorcontrib><creatorcontrib>Blyuss, Oleg</creatorcontrib><creatorcontrib>Nekliudov, Nikita</creatorcontrib><creatorcontrib>Bugaeva, Polina</creatorcontrib><creatorcontrib>Andreeva, Margarita</creatorcontrib><creatorcontrib>DunnGalvin, Audrey</creatorcontrib><creatorcontrib>Comberiati, Pasquale</creatorcontrib><creatorcontrib>Apfelbacher, Christian</creatorcontrib><creatorcontrib>Genuneit, Jon</creatorcontrib><creatorcontrib>Avdeev, Sergey</creatorcontrib><creatorcontrib>Kapustina, Valentina</creatorcontrib><creatorcontrib>Guekht, Alla</creatorcontrib><creatorcontrib>Fomin, Victor</creatorcontrib><creatorcontrib>Svistunov, Andrey A.</creatorcontrib><creatorcontrib>Timashev, Peter</creatorcontrib><creatorcontrib>Subbot, Vladislav S.</creatorcontrib><creatorcontrib>Royuk, Valery V.</creatorcontrib><creatorcontrib>Drake, Thomas M.</creatorcontrib><creatorcontrib>Hanson, Sarah Wulf</creatorcontrib><creatorcontrib>Merson, Laura</creatorcontrib><creatorcontrib>Carson, Gail</creatorcontrib><creatorcontrib>Horby, Peter</creatorcontrib><creatorcontrib>Sigfrid, Louise</creatorcontrib><creatorcontrib>Scott, Janet T.</creatorcontrib><creatorcontrib>Semple, Malcolm G.</creatorcontrib><creatorcontrib>Warner, John O.</creatorcontrib><creatorcontrib>Vos, Theo</creatorcontrib><creatorcontrib>Olliaro, Piero</creatorcontrib><creatorcontrib>Glybochko, Petr</creatorcontrib><creatorcontrib>Butnaru, Denis</creatorcontrib><creatorcontrib>Abdeeva, Elina</creatorcontrib><creatorcontrib>Alekseeva, Nikol</creatorcontrib><creatorcontrib>Antsiferova, Elena</creatorcontrib><creatorcontrib>Artigas, Elena</creatorcontrib><creatorcontrib>Bairashevskaia, Anastasiia</creatorcontrib><creatorcontrib>Belkina, Anna</creatorcontrib><creatorcontrib>Bezrukov, Vadim</creatorcontrib><creatorcontrib>Bordyugov, Semyon</creatorcontrib><creatorcontrib>Bratukhina, Maria</creatorcontrib><creatorcontrib>Chen, Jessica</creatorcontrib><creatorcontrib>Deunezhewa, Salima</creatorcontrib><creatorcontrib>Elifkhanova, Khalisa</creatorcontrib><creatorcontrib>Ezhova, Anastasia</creatorcontrib><creatorcontrib>Filippova, Yulia</creatorcontrib><creatorcontrib>Frolova, Aleksandra</creatorcontrib><creatorcontrib>Ganieva, Julia</creatorcontrib><creatorcontrib>Gorina, Anastasia</creatorcontrib><creatorcontrib>Kalan, Yulia</creatorcontrib><creatorcontrib>Kirillov, Bogdan</creatorcontrib><creatorcontrib>Korgunova, Mariia</creatorcontrib><creatorcontrib>Krupina, Alexandra</creatorcontrib><creatorcontrib>Kuznetsova, Anna</creatorcontrib><creatorcontrib>Listovskaia, Ekaterina</creatorcontrib><creatorcontrib>Mikheeva, Margarita</creatorcontrib><creatorcontrib>Mursalova, Aigun</creatorcontrib><creatorcontrib>Ogandzhanova, Marina</creatorcontrib><creatorcontrib>Parr, Callum</creatorcontrib><creatorcontrib>Rumyantsev, Mikhail</creatorcontrib><creatorcontrib>Smirnov, Denis</creatorcontrib><creatorcontrib>Shishkina, Nataliya</creatorcontrib><creatorcontrib>El‐Taravi, Yasmin</creatorcontrib><creatorcontrib>Varaksina, Maria</creatorcontrib><creatorcontrib>Vodianova, Maria</creatorcontrib><creatorcontrib>Zezyulina, Anna</creatorcontrib><creatorcontrib>Sechenov StopCOVID Research Team</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Munblit, Daniel</au><au>Bobkova, Polina</au><au>Spiridonova, Ekaterina</au><au>Shikhaleva, Anastasia</au><au>Gamirova, Aysylu</au><au>Blyuss, Oleg</au><au>Nekliudov, Nikita</au><au>Bugaeva, Polina</au><au>Andreeva, Margarita</au><au>DunnGalvin, Audrey</au><au>Comberiati, Pasquale</au><au>Apfelbacher, Christian</au><au>Genuneit, Jon</au><au>Avdeev, Sergey</au><au>Kapustina, Valentina</au><au>Guekht, Alla</au><au>Fomin, Victor</au><au>Svistunov, Andrey A.</au><au>Timashev, Peter</au><au>Subbot, Vladislav S.</au><au>Royuk, Valery V.</au><au>Drake, Thomas M.</au><au>Hanson, Sarah Wulf</au><au>Merson, Laura</au><au>Carson, Gail</au><au>Horby, Peter</au><au>Sigfrid, Louise</au><au>Scott, Janet T.</au><au>Semple, Malcolm G.</au><au>Warner, John O.</au><au>Vos, Theo</au><au>Olliaro, Piero</au><au>Glybochko, Petr</au><au>Butnaru, Denis</au><au>Abdeeva, Elina</au><au>Alekseeva, Nikol</au><au>Antsiferova, Elena</au><au>Artigas, Elena</au><au>Bairashevskaia, Anastasiia</au><au>Belkina, Anna</au><au>Bezrukov, Vadim</au><au>Bordyugov, Semyon</au><au>Bratukhina, Maria</au><au>Chen, Jessica</au><au>Deunezhewa, Salima</au><au>Elifkhanova, Khalisa</au><au>Ezhova, Anastasia</au><au>Filippova, Yulia</au><au>Frolova, Aleksandra</au><au>Ganieva, Julia</au><au>Gorina, Anastasia</au><au>Kalan, Yulia</au><au>Kirillov, Bogdan</au><au>Korgunova, Mariia</au><au>Krupina, Alexandra</au><au>Kuznetsova, Anna</au><au>Listovskaia, Ekaterina</au><au>Mikheeva, Margarita</au><au>Mursalova, Aigun</au><au>Ogandzhanova, Marina</au><au>Parr, Callum</au><au>Rumyantsev, Mikhail</au><au>Smirnov, Denis</au><au>Shishkina, Nataliya</au><au>El‐Taravi, Yasmin</au><au>Varaksina, Maria</au><au>Vodianova, Maria</au><au>Zezyulina, Anna</au><aucorp>Sechenov StopCOVID Research Team</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID‐19</atitle><jtitle>Clinical and experimental allergy</jtitle><addtitle>Clin Exp Allergy</addtitle><date>2021-09</date><risdate>2021</risdate><volume>51</volume><issue>9</issue><spage>1107</spage><epage>1120</epage><pages>1107-1120</pages><issn>0954-7894</issn><issn>1365-2222</issn><eissn>1365-2222</eissn><abstract>Background The long‐term sequalae of COVID‐19 remain poorly characterized. We assessed persistent symptoms in previously hospitalized patients with COVID‐19 and assessed potential risk factors. Methods Data were collected from patients discharged from 4 hospitals in Moscow, Russia between 8 April and 10 July 2020. Participants were interviewed via telephone using an ISARIC Long‐term Follow‐up Study questionnaire. Results 2,649 of 4755 (56%) discharged patients were successfully evaluated, at median 218 (IQR 200, 236) days post‐discharge. COVID‐19 diagnosis was clinical in 1291 and molecular in 1358. Most cases were mild, but 902 (34%) required supplemental oxygen and 68 (2.6%) needed ventilatory support. Median age was 56 years (IQR 46, 66) and 1,353 (51.1%) were women. Persistent symptoms were reported by 1247 (47.1%) participants, with fatigue (21.2%), shortness of breath (14.5%) and forgetfulness (9.1%) the most common symptoms and chronic fatigue (25%) and respiratory (17.2%) the most common symptom categories. Female sex was associated with any persistent symptom category OR 1.83 (95% CI 1.55 to 2.17) with association being strongest for dermatological (3.26, 2.36 to 4.57) symptoms. Asthma and chronic pulmonary disease were not associated with persistent symptoms overall, but asthma was associated with neurological (1.95, 1.25 to 2.98) and mood and behavioural changes (2.02, 1.24 to 3.18), and chronic pulmonary disease was associated with chronic fatigue (1.68, 1.21 to 2.32). Conclusions Almost half of adults admitted to hospital due to COVID‐19 reported persistent symptoms 6 to 8 months after discharge. Fatigue and respiratory symptoms were most common, and female sex was associated with persistent symptoms. Word cloud showing persistent symptoms 6–8 months since hospital discharge in people previously hospitalised with COVID‐19.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34351016</pmid><doi>10.1111/cea.13997</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-5764-1528</orcidid><orcidid>https://orcid.org/0000-0001-9652-6856</orcidid><orcidid>https://orcid.org/0000-0001-5209-9733</orcidid><orcidid>https://orcid.org/0000-0002-7834-7819</orcidid><orcidid>https://orcid.org/0000-0002-1540-3959</orcidid><orcidid>https://orcid.org/0000-0001-9700-0418</orcidid><oa>free_for_read</oa></addata></record>
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identifier	ISSN: 0954-7894
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subjects	Adolescent Adult Aftercare Aged Aged, 80 and over Asthma COVID-19 COVID-19 - epidemiology COVID-19 Drug Treatment COVID-19 Testing Fatigue Female Follow-Up Studies Hospitalization Humans Incidence Long COVID Lung diseases Male Middle Aged ORIGINAL ARTICLES Original ‐asthma and Rhinitis PASC Patients postacute sequelae SARS‐CoV‐2 infection post‐COVID Condition post‐COVID Syndrome Risk Factors Russia - epidemiology SARS-CoV-2 Surveys and Questionnaires
title	Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID‐19
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